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公开(公告)号：US11771745B2
公开(公告)日：2023-10-03
申请号：US17362633
申请日：2021-06-29
Inventor： Jan P. Kraus , Tomas Majtan , Erez Bublil
IPC: A61K38/51 , A61K9/00 , A61K31/198 , A61K31/205 , A61K31/385 , A61K45/06 , A61K47/60 , C12N9/88 , C12N9/96 , A61P19/10 , A61P43/00 , A61P13/02 , A61P17/14 , A61P27/02
CPC classification number: A61K38/51 , A61K9/0019 , A61K31/198 , A61K31/205 , A61K31/385 , A61K45/06 , A61K47/60 , C12N9/88 , C12N9/96 , C12Y402/01022 , A61K2300/00
Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
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公开(公告)号：US20230039591A1
公开(公告)日：2023-02-09
申请号：US17713891
申请日：2022-04-05
Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , Travere Therapeutics Switzerland GmbH
Inventor： Tomas Majtan , Jan P. Kraus , Erez M. Bublil , Frank Glavin , Marcia Sellos-Moura
Abstract: The present invention provides a method of PEGylating a human truncated cystathionine β-synthase protein containing a mutation of a cysteine to a serine at amino acid position 15 (htCBS C15S). The htCBS C15S was PEGylated with one of 5 kDa, 10 kDa, or 20 kDa NHS ester PEG molecules. In-process monitoring of the PEGylation process was used in the method to reduce levels of unPEGylated htCBS C15S and htCBS C15S with insufficient PEGylation. Administration of the PEGylated htCBS C15S had efficacy throughout the course of treatment for homocystinuria.
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公开(公告)号：US20190055537A1
公开(公告)日：2019-02-21
申请号：US16178024
申请日：2018-11-01
Inventor： Richard Carrillo , Jan P. Kraus , Tomas Majtan , David Naveh
Abstract: This invention provides chromatographic methods for the purification of a cystathionine β-Synthase (CBS) protein, particularly truncated variants thereof and compositions and pharmaceutical compositions prepared therefrom.
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4.发明申请公开(公告)号：US20180311325A1
公开(公告)日：2018-11-01
申请号：US16025652
申请日：2018-07-02
Inventor： Jan P. Kraus , Tomas Majtan , Erez Bublil
IPC: A61K38/51 , A61K45/06 , C12N9/88 , C12N9/96 , A61K47/60 , A61K9/00 , A61K31/198 , A61K31/205 , A61K31/385
CPC classification number: A61K38/51 , A61K9/0019 , A61K31/198 , A61K31/205 , A61K31/385 , A61K45/06 , A61K47/60 , C12N9/88 , C12N9/96 , C12Y402/01022 , A61K2300/00
Abstract: The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine β-synthase (CBS) to treat homocystinuria and other related diseases and disorders.
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5.发明授权Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria 有权用于治疗同型胱尿蛋白尿的化学修饰的胱硫醚β-合酶公开(公告)号：US09034318B2
公开(公告)日：2015-05-19
申请号：US13803804
申请日：2013-03-14
Inventor： Jan P Kraus , Tomas Majtan , Erez Bublil
IPC: A61K38/54 , C12N9/96 , C12N9/88 , C07H21/04 , C07K1/00 , A61K38/51 , A61K45/06 , A61K31/198 , A61K31/205 , A61K31/385 , A61K9/00
CPC classification number: A61K38/51 , A61K9/0019 , A61K31/198 , A61K31/205 , A61K31/385 , A61K45/06 , A61K47/60 , C12N9/88 , C12N9/96 , C12Y402/01022 , A61K2300/00
Abstract: The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine β-synthase (CBS) to treat homocystinuria and other related diseases and disorders.
Abstract translation: 本发明提供了使用化学修饰的人类胱硫醚和半胱氨酸（CBS）物质进行酶替代治疗以治疗同胱尿蛋白尿和其它相关疾病和病症的试剂和方法。
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Patent Agency Ranking
公开(公告)号：US20250041392A1
公开(公告)日：2025-02-06
申请号：US18658735
申请日：2024-05-08
Inventor： Jan P. Kraus , Tomas Majtan , Erez Bublil
IPC: A61K38/51 , A61K9/00 , A61K31/198 , A61K31/205 , A61K31/385 , A61K45/06 , A61K47/60 , C12N9/88 , C12N9/96
Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
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公开(公告)号：US20240091325A1
公开(公告)日：2024-03-21
申请号：US18454701
申请日：2023-08-23
Inventor： Jan P. Kraus , Tomas Majtan , Erez Bublil
IPC: A61K38/51 , A61K9/00 , A61K31/198 , A61K31/205 , A61K31/385 , A61K45/06 , A61K47/60 , C12N9/88 , C12N9/96
CPC classification number: A61K38/51 , A61K9/0019 , A61K31/198 , A61K31/205 , A61K31/385 , A61K45/06 , A61K47/60 , C12N9/88 , C12N9/96 , C12Y402/01022 , A61K2300/00
Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
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公开(公告)号：US20200316179A1
公开(公告)日：2020-10-08
申请号：US16910735
申请日：2020-06-24
Inventor： Jan P. Kraus , Tomas Majtan , Erez Bublil
IPC: A61K38/51 , A61K31/205 , A61K47/60 , A61K9/00 , A61K45/06 , C12N9/88 , C12N9/96 , A61K31/198 , A61K31/385
Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
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公开(公告)号：US10729753B2
公开(公告)日：2020-08-04
申请号：US16243295
申请日：2019-01-09
Inventor： Jan P. Kraus , Tomas Majtan , Erez Bublil
IPC: A61K38/51 , A61K31/385 , A61K31/198 , A61K47/60 , C12N9/96 , C12N9/88 , A61K45/06 , A61K9/00 , A61K31/205
Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
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公开(公告)号：US20190125845A1
公开(公告)日：2019-05-02
申请号：US16243295
申请日：2019-01-09
Inventor： Jan P. Kraus , Tomas Majtan , Erez Bublil
IPC: A61K38/51 , C12N9/96 , C12N9/88 , A61K45/06 , A61K9/00 , A61K31/205 , A61K31/198 , A61K31/385 , A61K47/60
Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
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