公开(公告)号：US20240091386A1

公开(公告)日：2024-03-21

申请号：US17930234

申请日：2022-09-07

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE ,  THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND ,  RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

发明人： Ravi Mahalingam ,  Vicki L. Traina-Dorge ,  Hua Zhu

IPC分类号： A61K49/00 ,  C07K14/005 ,  C12N7/00

CPC分类号： A61K49/0008 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/16721 ,  C12N2710/16722 ,  C12N2710/16751

摘要： Embodiments of the instantly claimed inventions include, but are not limited to, chimeric viral constructs, non-human primate models, in vivo screening systems for antiviral agents, gene therapy delivery systems, and methods of making and using the same. In some embodiments, chimeric viral constructs include a non-human primate infecting virus nucleic acid sequence and a exclusively human pathogenic virus nucleic acid sequence for use in creating a non-human primate model and uses thereof. In other embodiments, systems for testing antiviral agents are disclosed. In other embodiments, gene therapy delivery systems disclosed herein can be used to deliver a vector containing or associated with an agent to a human subject for treating conditions of the skin and neuronal ganglia in the subject.