公开(公告)号：US10945757B2

公开(公告)日：2021-03-16

申请号：US16342573

申请日：2017-10-17

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Hitinder S. Gurm ,  Yao Liu ,  Yang Liu ,  Yihao Zheng ,  Albert Shih

IPC: A61B17/3207 ,  A61B17/00 ,  A61B17/32

Abstract: A method of two-phase atherectomy for removal of plaque within an artery forming a stenosis including a first phase of rotational drilling by exerting a rotational force on a cutter to form a channel within the plaque having a diameter substantially equal to a diameter of the cutter—the cutter being rotated at a first rotational speed sufficient to maintain rotation of the cutter about a stationary rotational axis—and a second phase of orbital impact by exerting a rotational force on the cutter to result in radial orbital motion of the cutter within the channel resulting in periodic impact of the cutter upon the plaque to form micro-fractures within the plaque and enlarge the diameter of the channel to a diameter substantially greater than the diameter of the cutter—the cutter being rotated at a second rotational speed to result in the radial orbital motion of the cutter.

公开(公告)号：US20180345650A1

公开(公告)日：2018-12-06

申请号：US15610114

申请日：2017-05-31

Applicant: The Regents of the University of Michigan ,  Stratasys, Inc.

Inventor： Robert Chisena ,  Miguel Angel Funes Lora ,  Albert Shih ,  Darren Bolger ,  Jeffrey Wensman ,  Andrew Hanson ,  Gary Larson ,  Chris Holshouser

IPC: B33Y80/00 ,  B29C67/00 ,  B33Y10/00 ,  B33Y50/02

Abstract: Disclosed are three-dimensional parts, such as orthotics and prosthetics, having sinusoidal wave pattern infill structures first and second boundary walls. Also disclosed are printers or systems configured to manufacture such parts, as well as methods of manufacturing such parts. The sinusoidal wave pattern infill structures are formed between, and normal to, the first and second boundary walls and are configured to provide locally tunable structural properties in different regions of the part.

公开(公告)号：US10926529B2

公开(公告)日：2021-02-23

申请号：US16790325

申请日：2020-02-13

Applicant: The Regents of the University of Michigan ,  Stratasys, Inc.

Inventor： Robert Chisena ,  Miguel Angel Funes Lora ,  Albert Shih ,  Darren Bolger ,  Jeffrey Wensman ,  Andrew Hanson ,  Gary Larson ,  Chris Holshouser

IPC: B33Y80/00 ,  B33Y10/00 ,  B33Y50/02 ,  B29C64/386 ,  B29C64/118 ,  B29D99/00 ,  B33Y30/00 ,  B29L31/00 ,  A61F2/76

Abstract: Disclosed are three-dimensional parts, such as orthotics and prosthetics, having sinusoidal wave pattern infill structures first and second boundary walls. Also disclosed are printers or systems configured to manufacture such parts, as well as methods of manufacturing such parts. The sinusoidal wave pattern infill structures are formed between, and normal to, the first and second boundary walls and are configured to provide locally tunable structural properties in different regions of the part.

公开(公告)号：US20200180298A1

公开(公告)日：2020-06-11

申请号：US16790325

申请日：2020-02-13

Applicant: The Regents of the University of Michigan ,  Stratasys, Inc.

Inventor： Robert Chisena ,  Miguel Angel Funes Lora ,  Albert Shih ,  Darren Bolger ,  Jeffrey Wensman ,  Andrew Hanson ,  Gary Larson ,  Chris Holshouser

IPC: B33Y80/00 ,  B33Y50/02 ,  B33Y10/00 ,  B33Y30/00 ,  B29D99/00 ,  B29C64/118 ,  B29C64/386

Abstract: Disclosed are three-dimensional parts, such as orthotics and prosthetics, having sinusoidal wave pattern infill structures first and second boundary walls. Also disclosed are printers or systems configured to manufacture such parts, as well as methods of manufacturing such parts. The sinusoidal wave pattern infill structures are formed between, and normal to, the first and second boundary walls and are configured to provide locally tunable structural properties in different regions of the part.

公开(公告)号：US20240277978A1

公开(公告)日：2024-08-22

申请号：US18654479

申请日：2024-05-03

Applicant: The Regents of The University of Michigan

Inventor： Robert CHISENA ,  Hitinder S. Gurm ,  Matthew Hildner ,  Yihao Zheng ,  Albert Shih

IPC: A61M25/10 ,  A61B17/00 ,  A61B17/22

CPC classification number: A61M25/10182 ,  A61B17/22012 ,  A61M25/10185 ,  A61B2017/00154 ,  A61B2017/00181 ,  A61B2017/00539 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2017/22062 ,  A61M2205/3344

Abstract: A dynamic balloon angioplasty system for applying a dynamic pressure to fracture hardened materials embedded within an elastic conduit. The system having a pressure source system outputting at least a first predetermined pressure from a pressure source outlet, and an angioplasty unit fluidly coupled to the pressure source outlet receiving at least the first predetermined pressure. The angioplasty unit having an angioplasty inflation device, an angioplasty balloon connector, and an oscillating mechanism selectively actuated to output a plurality of pressure pulses to the angioplasty balloon via a fluid communication path. A control system is configured to determine an optimal hydraulic pressure oscillation frequency and amplitude for a given procedure and output a control signal to the oscillating mechanism, and monitor a pressure signal to detect fracture of the hardened material within the elastic conduit or system failure or leakage.

公开(公告)号：US12005210B2

公开(公告)日：2024-06-11

申请号：US17897604

申请日：2022-08-29

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Robert Chisena ,  Hitinder S. Gurm ,  Matthew Hildner ,  Yihao Zheng ,  Albert Shih

IPC: A61M25/10 ,  A61B17/22 ,  A61B17/00

CPC classification number: A61M25/10182 ,  A61B17/22012 ,  A61M25/10185 ,  A61B2017/00154 ,  A61B2017/00181 ,  A61B2017/00539 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2017/22062 ,  A61M2205/3344

Abstract: A dynamic balloon angioplasty system for applying a dynamic pressure to fracture hardened materials embedded within an elastic conduit. The system having a pressure source system outputting at least a first predetermined pressure from a pressure source outlet, and an angioplasty unit fluidly coupled to the pressure source outlet receiving at least the first predetermined pressure. The angioplasty unit having an angioplasty inflation device, an angioplasty balloon connector, and an oscillating mechanism selectively actuated to output a plurality of pressure pulses to the angioplasty balloon via a fluid communication path. A control system is configured to determine an optimal hydraulic pressure oscillation frequency and amplitude for a given procedure and output a control signal to the oscillating mechanism, and monitor a pressure signal to detect fracture of the hardened material within the elastic conduit or system failure or leakage.

公开(公告)号：US11464949B2

公开(公告)日：2022-10-11

申请号：US16654073

申请日：2019-10-16

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Robert Chisena ,  Hitinder S. Gurm ,  Matthew Hildner ,  Yihao Zheng ,  Albert Shih

IPC: A61M25/10 ,  A61B17/22 ,  A61B17/00

Abstract: A dynamic balloon angioplasty system for applying a dynamic pressure to fracture hardened materials embedded within an elastic conduit. The system having a pressure source system outputting at least a first predetermined pressure from a pressure source outlet, and an angioplasty unit fluidly coupled to the pressure source outlet receiving at least the first predetermined pressure. The angioplasty unit having an angioplasty inflation device, an angioplasty balloon connector, and an oscillating mechanism selectively actuated to output a plurality of pressure pulses to the angioplasty balloon via a fluid communication path. A control system is configured to determine an optimal hydraulic pressure oscillation frequency and amplitude for a given procedure and output a control signal to the oscillating mechanism, and monitor a pressure signal to detect fracture of the hardened material within the elastic conduit or system failure or leakage.

公开(公告)号：US11185344B2

公开(公告)日：2021-11-30

申请号：US15556893

申请日：2016-03-11

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Nicholas B. Langhals ,  Cynthia Anne Chestek ,  Paul S. Cederna ,  Albert Shih ,  Melanie G. Urbanchek ,  Grant H. Kruger ,  Jeffrey Stephen Plott ,  Jordan T. Kreda

IPC: A61B17/295 ,  A61B17/3205 ,  A61B17/34 ,  A61B17/29 ,  A61B17/11 ,  A61B90/00 ,  A61B17/00

Abstract: The present disclosure provides a mechanically-actuated tool for cutting a tissue graft having a hollow core and methods for use thereof. A portion of a biological structure, such as a nerve, is attached to the hollow core to form an implantable neural graft assembly. The tool has a cutter mechanism and a grasper mechanism. The grasper mechanism has one or more component(s) that open and close via an actuation mechanism, like a handle, and rotate via a controller component, like a rotatable wheel. The cutter mechanism may be a cutting tube component that harvests the tissue graft. The tool may also have an ejector mechanism to remove the tissue graft as part of the implantable neural graft assembly. Such devices and methods are particularly suitable for treating neuromas and other neural regeneration procedures.