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公开(公告)号：US11746151B2
公开(公告)日：2023-09-05
申请号：US17046998
申请日：2019-04-12
Applicant: The Regents of the University of Michigan
Inventor： Arul Chinnaiyan , Dan Robinson , Yi-Mi Wu , Marcin Cieslik
IPC: C07K16/28 , A61P35/00 , C12Q1/6886
CPC classification number: C07K16/2818 , A61P35/00 , C07K16/28 , C12Q1/6886 , C07K2317/21 , C07K2317/24 , C07K2319/30 , C12Q2600/106 , C12Q2600/156
Abstract: Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of targeted therapy to treat cancer (e.g., prostate cancer) in subjects with CDK12 mutations.
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公开(公告)号：US10174381B2
公开(公告)日：2019-01-08
申请号：US14513501
申请日：2014-10-14
Applicant: The Regents of the University of Michigan
Inventor： Arul M. Chinnaiyan , Dan Robinson , Yi-Mi Wu
IPC: C07H21/02 , C07H21/04 , C12Q1/6886 , C07K14/72 , G01N33/574 , C07K14/705
Abstract: The present disclosure relates to methods of determining a treatment course of action. In particular, the present disclosure relates to mutations in the gene encoding estrogen receptor and their association with responsiveness to estrogen therapies for cancer.
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公开(公告)号：US11697852B2
公开(公告)日：2023-07-11
申请号：US16241565
申请日：2019-01-07
Applicant: The Regents of the University of Michigan
Inventor： Arul M. Chinnaiyan , Dan Robinson , Yi-Mi Wu
IPC: C12Q1/68 , C12P19/34 , C12Q1/6886 , G01N33/574 , C07K14/705 , C07K14/72
CPC classification number: C12Q1/6886 , C07K14/70567 , C07K14/721 , G01N33/57415 , G01N33/57442 , C12Q2600/106 , C12Q2600/156 , G01N2333/723
Abstract: The present disclosure relates to methods of determining a treatment course of action. In particular, the present disclosure relates to mutations in the gene encoding estrogen receptor and their association with responsiveness to estrogen therapies for cancer.
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公开(公告)号：US09476096B2
公开(公告)日：2016-10-25
申请号：US13962590
申请日：2013-08-08
Applicant: The Regents of The University of Michigan
Inventor： Arul Chinnaiyan , Dan Robinson
IPC: C12Q1/68 , G01N33/574 , G01N33/569
CPC classification number: C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , G01N33/56966 , G01N33/57407
Abstract: Provided herein are kits, compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusions as diagnostic markers and clinical targets for hemangiopericytoma.
Abstract translation: 本文提供用于癌症诊断，研究和治疗的试剂盒，组合物和方法，包括但不限于癌症标志物。 特别地，本发明涉及作为血管外皮细胞瘤的诊断标记物和临床靶标的复发性基因融合体。
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Patent Agency Ranking
公开(公告)号：US20150017637A1
公开(公告)日：2015-01-15
申请号：US14329639
申请日：2014-07-11
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Arul Chinnaiyan , Yi-Mi Wu , Dan Robinson
IPC: C12Q1/68 , G01N33/574
CPC classification number: C12Q1/6886 , C12Q2600/156 , G01N33/57492 , G01N2333/71
Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to gene fusions as diagnostic markers and clinical targets for cancer.
Abstract translation: 本公开涉及用于癌症诊断，研究和治疗的组合物和方法，包括但不限于癌症标志物。 特别地，本发明涉及基因融合作为癌症的诊断标志物和临床靶标。
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公开(公告)号：US20140178871A1
公开(公告)日：2014-06-26
申请号：US13962590
申请日：2013-08-08
Applicant: The Regents of The University of Michigan
Inventor： Arul Chinnaiyan , Dan Robinson
IPC: C12Q1/68 , G01N33/569
CPC classification number: C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , G01N33/56966 , G01N33/57407
Abstract: Provided herein are kits, compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusions as diagnostic markers and clinical targets for hemangiopericytoma.
Abstract translation: 本文提供用于癌症诊断，研究和治疗的试剂盒，组合物和方法，包括但不限于癌症标志物。 特别地，本发明涉及作为血管外皮细胞瘤的诊断标记物和临床靶标的复发性基因融合体。
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公开(公告)号：US20190271045A1
公开(公告)日：2019-09-05
申请号：US16241565
申请日：2019-01-07
Applicant: The Regents of the University of Michigan
Inventor： Arul M. Chinnaiyan , Dan Robinson , Yi-Mi Wu
IPC: C12Q1/6886 , C07K14/705 , G01N33/574 , C07K14/72
Abstract: The present disclosure relates to methods of determining a treatment course of action. In particular, the present disclosure relates to mutations in the gene encoding estrogen receptor and their association with responsiveness to estrogen therapies for cancer.
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公开(公告)号：US09783853B2
公开(公告)日：2017-10-10
申请号：US14329639
申请日：2014-07-11
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Arul Chinnaiyan , Yi-Mi Wu , Dan Robinson
IPC: C12Q1/68 , G01N33/574
CPC classification number: C12Q1/6886 , C12Q2600/156 , G01N33/57492 , G01N2333/71
Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to gene fusions as diagnostic markers and clinical targets for cancer.
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公开(公告)号：US20150141391A1
公开(公告)日：2015-05-21
申请号：US14513501
申请日：2014-10-14
Applicant: The Regents of the University of Michigan
Inventor： Arul M. Chinnaiyan , Dan Robinson , Yi-Mi Wu
CPC classification number: C12Q1/6886 , C07K14/70567 , C07K14/721 , C12Q2600/106 , C12Q2600/156 , G01N33/57415 , G01N33/57442 , G01N2333/723
Abstract: The present disclosure relates to methods of determining a treatment course of action. In particular, the present disclosure relates to mutations in the gene encoding estrogen receptor and their association with responsiveness to estrogen therapies for cancer.
Abstract translation: 本公开涉及确定治疗疗程的方法。 特别地，本公开涉及编码雌激素受体的基因中的突变及其与对癌症的雌激素疗法的反应性的关联。
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