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公开(公告)号:US12145944B2
公开(公告)日:2024-11-19
申请号:US16971472
申请日:2020-07-16
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor: Shaomeng Wang , Rohan Rej , Changwei Wang , Mi Wang , Jianfeng Lu , Chao-Yie Yang , Ester Fernandez-Salas , Jeanne Stuckey
IPC: A61K31/277 , A61K45/06 , A61P35/00 , C07D471/22 , C07D487/04 , C07D487/14 , C07D491/22 , C07D495/14 , C07D495/22 , C07D498/22 , C07D513/22 , C07F9/6561
Abstract: The present disclosure provides compounds represented by Formula I: wherein R1, R2, R3, and R4 are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are EED inhibitors. EED inhibitors are useful for the treatment of cancer and other diseases.
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公开(公告)号:US20250034162A1
公开(公告)日:2025-01-30
申请号:US18887703
申请日:2024-09-17
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor: Shaomeng Wang , Rohan Rej , Changwei Wang , Mi Wang , Jianfeng Lu , Chao-Yie Yang , Ester Fernandez-Salas , Jeanne Stuckey
IPC: C07D491/22 , A61K45/06 , A61P35/00 , C07D471/22 , C07D487/04 , C07D487/14 , C07D495/14 , C07D495/22 , C07D498/22 , C07D513/22 , C07F9/6561
Abstract: The present disclosure provides compounds represented by Formula I: wherein R1, R2, R3, and R4 are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are EED inhibitors. EED inhibitors are useful for the treatment of cancer and other diseases.
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公开(公告)号:US20220227778A1
公开(公告)日:2022-07-21
申请号:US16971472
申请日:2020-07-16
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor: Shaomeng Wang , Rohan Rej , Changwei Wang , Mi Wang , Jianfeng Lu , Chao-Yie Yang , Ester Fernandez-Salas , Jeanne Stuckey
IPC: C07D491/22 , C07D487/14 , C07D471/22 , C07D495/14 , C07D495/22 , C07D513/22 , C07D487/04 , C07F9/6561 , C07D498/22 , A61P35/00 , A61K45/06
Abstract: The present disclosure provides compounds represented by Formula I: wherein R1, R2, R3, and R4 are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are EED inhibitors. EED inhibitors are useful for the treatment of cancer and other diseases.
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