公开(公告)号：US20230357710A1

公开(公告)日：2023-11-09

申请号：US18143871

申请日：2023-05-05

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Joerg LAHANN ,  Mirella WAWRYSZYN ,  Dylan B. NEALE

IPC: C12N5/00

CPC classification number: C12N5/0062 ,  C12N2533/14 ,  C12N2533/40 ,  C12N2533/52 ,  C12N2533/78 ,  C12N2513/00 ,  C12N2535/00

Abstract: Synthetic cellular support systems in the form of engineered extracellular matrices are provided. The cellular support system may include a three-dimensional scaffold structure comprising at least one void. At least one suspended fibril spans across the at least one void in the three-dimensional scaffold structure. The suspended fibril comprises at least one extracellular matrix protein, such as fibronectin, and at least one glycan, such as a hyaluronic acid. The suspended fibril is capable of supporting cells and promoting three-dimensional cellular growth. In various aspects, a plurality of suspended fibrils may span the void to form a three-dimensional suspended fibrillar network.