公开(公告)号：US20200038327A1

公开(公告)日：2020-02-06

申请号：US16494995

申请日：2018-03-16

Applicant: OHIO STATE INNOVATION FOUNDATION ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Susan R. MALLERY ,  Joerg LAHANN

IPC: A61K9/16 ,  A61K36/73 ,  A61K31/198 ,  A61K31/167 ,  A61K39/395 ,  A61K47/62 ,  A61K47/69 ,  A61K9/00 ,  A61K9/06

Abstract: Disclosed herein are nanoparticle compositions and methods of use such as for chemoprevention of cancer, for example oral squamous cell carcinoma (OSCC). The nanoparticle composition comprises a Janus particle comprising at least two chemopreventive agents, wherein at least one of the chemopreventive agents is selected from freeze-dried black raspberries (BRB), a synthetic vitamin A analogue, N-acetylcysteine (NAC), and an anti-interleukin 6 agent. Methods for improving oral health comprising administering to a subject the nanoparticle compositions are also disclosed.

公开(公告)号：US20230357710A1

公开(公告)日：2023-11-09

申请号：US18143871

申请日：2023-05-05

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Joerg LAHANN ,  Mirella WAWRYSZYN ,  Dylan B. NEALE

IPC: C12N5/00

CPC classification number: C12N5/0062 ,  C12N2533/14 ,  C12N2533/40 ,  C12N2533/52 ,  C12N2533/78 ,  C12N2513/00 ,  C12N2535/00

Abstract: Synthetic cellular support systems in the form of engineered extracellular matrices are provided. The cellular support system may include a three-dimensional scaffold structure comprising at least one void. At least one suspended fibril spans across the at least one void in the three-dimensional scaffold structure. The suspended fibril comprises at least one extracellular matrix protein, such as fibronectin, and at least one glycan, such as a hyaluronic acid. The suspended fibril is capable of supporting cells and promoting three-dimensional cellular growth. In various aspects, a plurality of suspended fibrils may span the void to form a three-dimensional suspended fibrillar network.

公开(公告)号：US20180177417A1

公开(公告)日：2018-06-28

申请号：US15899032

申请日：2018-02-19

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Daryl R. KIPKE ,  Takashi Daniel Yoshida KOZAI ,  Nick LANGHALS ,  Joerg LAHANN ,  Nicholas A. KOTOV ,  Xiaopei DENG ,  Paras PATEL

IPC: A61B5/04 ,  A61N1/05 ,  A61B5/00 ,  B82Y5/00

CPC classification number: A61B5/04001 ,  A61B5/685 ,  A61B2562/125 ,  A61N1/05 ,  A61N1/0529 ,  A61N1/0551 ,  B82Y5/00

Abstract: The present disclosure provides a method of fabricating an implantable micro-component electrode. The method includes disposing an electrically non-conductive material directly onto a surface of an electrically conductive carbon fiber core to generate an electrically non-conductive coating on the electrically conductive carbon fiber core, and removing a portion of the electrically non-conductive coating to expose a region of the electrically conductive carbon fiber core. The micro-component electrode has at least one dimension of less than or equal to about 10 μm.

公开(公告)号：US20210228744A1

公开(公告)日：2021-07-29

申请号：US17228039

申请日：2021-04-12

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  POZNAN UNIVERSITY OF MEDICAL SCIENCES

Inventor： Joerg LAHANN ,  Sywe-Ren CHANG ,  Brian CLARKSON ,  Nathan A. JONES ,  Agata CZAJKA-JAKUBOWSKA

IPC: A61K49/00 ,  A61K8/73 ,  A61K8/02 ,  A61K8/21 ,  A61K8/24 ,  A61K8/25 ,  A61K8/55 ,  A61K8/64 ,  A61K8/72 ,  A61Q11/00

Abstract: Components, for example, nanoparticles for detecting and/or treating one or more active carious lesions or microcavities in teeth of a subject are provided. The component or nanoparticle may comprise a biocompatible and biodegradable polymer (e.g., a starch) bearing at least one cationic region and/or having a net positive charge and thereby capable of associating with one or more active and/or early carious lesions on a tooth in an oral cavity of a subject. The components or nanoparticles are optionally water soluble or dispersible. The components or nanoparticle also comprises an imaging agent (e.g., a fluorophore or dye) bonded to the biocompatible and biodegradable polymer. The component or nanoparticle is thus capable of indicating the presence of one or more active carious lesions when the component or nanoparticle is associated therewith. Oral care compositions comprising such compounds/nanoparticles and methods of making and using the same are also provided.

公开(公告)号：US20160025605A1

公开(公告)日：2016-01-28

申请号：US14452285

申请日：2014-08-05

Applicant: Triton Systems, Inc. ,  The Regents of the University of Michigan

Inventor： Aniruddha WELING ,  Tyson LAWRENCE ,  Ken MAHMUD ,  Joerg LAHANN ,  James BURGESS ,  Leonid KRASNOBAEV

IPC: G01N1/40 ,  G01N33/00

CPC classification number: G01N1/405 ,  G01N1/44 ,  G01N33/0057 ,  Y10T436/173076 ,  Y10T436/25875

Abstract: A chemical sensing system includes a substrate material, a detector capable of indicating a presence of a target compound, gas, or vapor, and a heater for rapidly releasing compounds, gases and vapors from the substrate material. The substrate material acts to concentrate the compounds, gases, and vapors from a sample area for improved detection by the detector.

公开(公告)号：US20220395467A1

公开(公告)日：2022-12-15

申请号：US17775229

申请日：2020-11-06

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Nahal HABIBI ,  Joerg LAHANN ,  Sahar RAHMANI ,  Jason V. GREGORY ,  Daniel F. QUEVEDO ,  Bradley PLUMMER

IPC: A61K9/51 ,  A61K45/06

Abstract: Protein-based nanoparticles and methods of forming such protein-based nanoparticles via electrohydrodynamic jetting methods are provided. The nanoparticle may comprise a water-soluble protein having an average molecular weight of ≥ about 8 kDa and

公开(公告)号：US20220142936A1

公开(公告)日：2022-05-12

申请号：US17521414

申请日：2021-11-08

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Joerg LAHANN ,  Nahal HABIBI ,  Jason V. GREGORY ,  Maria CASTRO ,  Pedro LOWENSTEIN ,  Ava MAUSER ,  Padma KADIYALA ,  Daniel F. QUEVEDO ,  Felipe NUNEZ

IPC: A61K9/51 ,  A61P35/00 ,  A61K31/7105

Abstract: Protein-based nanoparticles for treating cancer, such as those characterized by intracranial tumors, and methods of forming such protein-based nanoparticles via electrohydrodynamic jetting methods are provided. The nanoparticle may comprise a water-soluble protein having an average molecular weight of ≥about 8 kDa and ≤about 700 kDa. In certain variations, the water-soluble protein is cross-linked (e.g., with an optional crosslinking agent) and defines a mesh structure having an average linear mesh size of ≥about 1 nm to ≤about 4 nm. The nanoparticle may have a transcription factor such as a therapeutic nucleic acid in the mesh structure. Methods of making such nanoparticles may include jetting a liquid comprising the water-soluble protein through a nozzle, followed by exposing the liquid to an electric field sufficient to solidify the liquid and form the protein-based nanoparticles described above.

公开(公告)号：US20190144818A1

公开(公告)日：2019-05-16

申请号：US16300499

申请日：2017-05-11

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Stacy RAMCHARAN ,  Luis SOLORIO ,  Jacob JORDAHL ,  Joerg LAHANN

IPC: C12N5/00

Abstract: A cellular support system comprises a three-dimensional scaffold structure comprising at least one void. At least one suspended protein bridge spans across the at least one void in the three-dimensional scaffold structure. The suspended protein bridge is capable of supporting cells and promotes three-dimensional cellular growth. In certain aspects, the protein in the suspended protein bridge is an extracellular matrix protein, such as collagens, laminins, fibronectins, and combinations thereof. Such a cellular support system supports thriving cell cultures in three-dimensions emulating cell growth in vivo in an extracellular matrix, including promoting cell remodeling. Methods for making such cellular support systems are also provided.

公开(公告)号：US20190136033A1

公开(公告)日：2019-05-09

申请号：US16093570

申请日：2017-04-14

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  WISCONSIN ALUMNI RESEARCH FOUNDATION

Inventor： Marco A. BEDOLLA PANTOJA ,  Nicholas L. ABBOTT ,  Kenneth CHENG ,  Joerg LAHANN

IPC: C08L25/18 ,  D01F6/46 ,  C09D133/00 ,  G02F1/1337 ,  G02F1/137

Abstract: Methods are provided for fabricating functional nanostructures (e.g., nanowires/nanofibers) via chemical vapor deposition polymerization of paracyclophanes or substituted paracyclophanes onto and through a structured fluid, such as a film of liquid crystals, on a substrate. A one-step process is provided that does not require the use of any solid templates, nor does it require any volatile solvents, additives or catalysts. The resulting nanowires/nanofibers can be in the form of aligned nanowires/nanofibers arrays supported on any solid material, in the form of nanofibers mats supported on porous materials, or as individual free-standing nanowires/nanofibers. By using chiral liquid crystals, chiral nanofibers can be fabricated. The functional nanowires/nanofibers can contain one or more type of surface reactive groups that allows for post surface chemical modifications on the nanowires/nanofibers. Such nanostructures can be used in a range of different applications, including in biomedical applications.