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公开(公告)号:US20240190874A1
公开(公告)日:2024-06-13
申请号:US18279229
申请日:2022-03-03
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor: Shaomeng Wang , Lijie Zhao , Xin Han , Weiguo Xiang
IPC: C07D471/10 , A61K31/438
CPC classification number: C07D471/10 , A61K31/438
Abstract: The present disclosure provides compounds of Formula (I): and the salts or solvates thereof, wherein A1, B1, L, and X2 are as defined in the specification. The present disclosure also relates to uses of the compounds, e.g., as androgen receptor degraders useful for the treatment of diseases (e.g., cancer).
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公开(公告)号:US20230257365A1
公开(公告)日:2023-08-17
申请号:US18012369
申请日:2021-07-09
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor: Shaomeng Wang , Xin Han , Weiguo Xiang , Chong Qin , Tianfeng Xu , Lijie Zhao
IPC: C07D401/14 , C07D451/06 , C07D451/14 , C07D519/00 , C07D487/04 , C07D487/10 , C07D471/04 , C07D491/08
CPC classification number: C07D401/14 , C07D451/06 , C07D451/14 , C07D519/00 , C07D487/04 , C07D487/10 , C07D471/04 , C07D491/08
Abstract: The present disclosure provides compounds represented by Formula I: A-L-B1 I, and the salts or solvates thereof, wherein A, L, and B1 are as defined in the specification. Compounds having Formula I are androgen receptor degraders useful for the treatment of cancer and other diseases.
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公开(公告)号:US20230233690A1
公开(公告)日:2023-07-27
申请号:US18012267
申请日:2021-07-09
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor: Shaomeng Wang , Xin Han , Weiguo Xiang , Chong Qin , Lijie Zhao
CPC classification number: A61K47/55 , A61K47/545
Abstract: The present disclosure provides compounds represented by Formula I: A-L-B1 and the salts or solvates thereof, wherein A, L, and B1 are as defined in the specification. Compounds having Formula I are androgen receptor degraders useful for the treatment of cancer and other diseases.
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公开(公告)号:US20230357249A1
公开(公告)日:2023-11-09
申请号:US17924242
申请日:2021-05-14
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor: Shaomeng Wang , Xin Han , Weiguo Xiang , Chong Qin , Tianfeng Xu , Lijie Zhao , Mingliang Wang , Rohan Rej
IPC: C07D487/04 , C07D519/00
CPC classification number: C07D487/04 , C07D519/00
Abstract: The present disclosure provides compounds represented by Formula I : A-L-B 1 I, and the salts or solvates thereof, wherein A, L, and B1 are as defined in the specification, ompounds having Formula I are androgen receptor degraders useful for the treatment of ancer and other diseases.
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公开(公告)号:US20220380368A1
公开(公告)日:2022-12-01
申请号:US17760786
申请日:2020-09-18
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor: Shaomeng Wang , Xin Han , Weiguo Xiang , Bukeyan Miao , Chong Qin , Lijie Zhao , Jianfeng Lu , Tianfeng Xu , Chao-Yie Yang
IPC: C07D471/10 , A61P35/00 , A61P13/08
Abstract: The present disclosure provides compounds represented by Formula (I) and the salts or solvates thereof, wherein R3a, E, L, A1, B1, X1, X2, Z1, and Z2 are as defined in the specification. Compounds having Formula (I) are androgen receptor degraders useful for the treatment of cancer and other diseases.
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