专利检索 ap:("THE REGENTS OF THE UNIVERSITY OF MICHIGAN") AND inv:"Mohamed Dit Mady Traore" 第 1 页

1.

发明公开
REMDESIVIR AND REMDESIVIR ANALOGS, SOLUTIONS, AND NANOPARTICLE, LIPOSOMAL, AND MICROPARTICLE COMPOSITIONS FOR TREATING VIRAL INFECTIONS 审中-公开

公开(公告)号：US20230183282A1

公开(公告)日：2023-06-15

申请号：US17995254

申请日：2021-04-01

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Duxin Sun , Wei Gao , Hongxiang Hu , Mohamed Dit Mady Traore , Yudong Song , Bo Wen , Miao He , Hebao Yuan , Ruiting Li

IPC分类号： C07H7/06 , A61P31/12 , A61K9/127 , A61K9/51

CPC分类号： C07H7/06 , A61P31/12 , A61K9/127 , A61K9/5169

摘要： The present invention relates to methods, compounds, and compositions for treating viral infections, including COVID-19 viral infections. In certain embodiments, the compositions comprise: i) a remdesivir analog, ii) remdesivir or a remdesivir analog, and a surfactant, a cyclodextrin, or a combination thereof, iii) nanoparticles comprising albumin and remdesivir or remdesivir analog, iv) liposomes comprising lipids and remdesivir or remdesivir analog; and/or v) microparticles comprising PLA and/or PLGA, and remdesivir or remdesivir analog. In certain embodiments, the compositions are aqueous (e.g., for intravenous administration). In other embodiments, the compositions are nebulized or in the form of a dry powder (e.g., for inhalation by an infected subject).