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公开(公告)号：US20240197711A1
公开(公告)日：2024-06-20
申请号：US18284892
申请日：2022-04-01
IPC分类号： A61K31/4709 , A61P35/00
CPC分类号： A61K31/4709 , A61P35/00
摘要： Provided herein are methods of treating a cancer comprising administering an EGFR degrader to a patient suffering therefrom and subjecting the patient to radiation. The cancer can express mutant, overexpressed or overly activated EGFR, mutant KRAS, or mutant BRAF.
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公开(公告)号：US11999731B2
公开(公告)日：2024-06-04
申请号：US17739358
申请日：2022-05-09
发明人： Mukesh K. Nyati , Theodore S. Lawrence , Christopher Whitehead , Jason Christopher Rech , Brennan Taylor Watch
IPC分类号： C07D471/10 , C07D233/70 , C07D233/84
CPC分类号： C07D471/10 , C07D233/70 , C07D233/84
摘要： Provided herein are compounds that modulate EGFR and methods of using the same, for example to treat cancer.
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公开(公告)号：US20220273643A1
公开(公告)日：2022-09-01
申请号：US17634265
申请日：2020-08-20
发明人： Mukesh K. Nyati
IPC分类号： A61K31/4709 , A61K9/00 , A61K31/4178 , A61P35/00 , C07D471/10
摘要： Disclosed are methods of treating cancer characterized by expression of at least one KRAS mutation, using a compound of Formula I, below, or a pharmaceutically acceptable salt thereof, or a prodrug thereof: (I) Also disclosed are methods of altering the level of KRAS or cMet in a cell characterized by expression of at least a KRAS mutation with the compound of Formula I.
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公开(公告)号：US11358965B2
公开(公告)日：2022-06-14
申请号：US16970655
申请日：2019-02-25
发明人： Mukesh K. Nyati , Theodore S. Lawrence , Christopher Whitehead , Jason Christopher Rech , Brennan Taylor Watch
IPC分类号： C07D471/10 , C07D233/70 , C07D233/84
摘要： Provided herein are compounds that modulate EGFR and methods of using the same, for example to treat cancer.
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公开(公告)号：US20200377503A1
公开(公告)日：2020-12-03
申请号：US16970655
申请日：2019-02-25
发明人： Mukesh K. Nyati , Theodore S. Lawrence , Christopher Whitehead , Jason Christopher Rech , Brennan Taylor Watch
IPC分类号： C07D471/10 , C07D233/70 , C07D233/84
摘要： Provided herein are compounds that modulate EGFR and methods of using the same, for example to treat cancer.
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公开(公告)号：US20230097789A1
公开(公告)日：2023-03-30
申请号：US17801327
申请日：2021-03-05
发明人： Mukesh K. Nyati , Theodore S. Lawrence , Christopher Whitehead , Jason Christopher Rech , Brennan Taylor Watch , Alexander Bridges
IPC分类号： C07D233/64 , A61P35/00 , C07D401/12
摘要： Provided herein are compounds that are useful in treating cancer.
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7.发明申请Inhibitors of the Epidermal Growth Factor Receptor- Heat Shock Protein 90 Binding Interaction 审中-公开表皮生长因子受体抑制剂 - 热休克蛋白90结合相互作用公开(公告)号：US20150218277A1
公开(公告)日：2015-08-06
申请号：US14694423
申请日：2015-04-23
IPC分类号： C07K16/28 , C07K5/10 , C07K7/06 , A61K38/08 , A61N5/10 , A61K39/395 , A61K31/7088 , A61K38/07 , A61K33/24 , A61K31/7068 , A61K9/00 , C12N15/113
CPC分类号： C07K16/2863 , A61K9/0019 , A61K31/7068 , A61K31/7088 , A61K33/24 , A61K38/00 , A61K38/07 , A61K38/08 , A61K39/39558 , A61K2039/505 , A61N5/10 , C07K5/10 , C07K7/06 , C07K14/71 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2319/10 , C07K2319/95 , C12N15/1138 , C12N2310/16
摘要： Provided herein are compounds that inhibit a binding interaction between an epidermal growth factor receptor (EGFR) and a heat shock protein 90 (HSP90), as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of increasing degradation of an EGFR, methods of treating cancer, and methods of sensitizing tumors to radiation therapy.
摘要翻译： 本文提供了抑制表皮生长因子受体（EGFR）和热休克蛋白90（HSP90）之间的结合相互作用的化合物，以及包含其的组合物，例如药物组合物和相关试剂盒。 在一些实施方案中，化合物是抗体或抗体类似物，并且在其它实施方案中，所述化合物是肽或肽类似物。 还提供了使用化合物的方法，包括增加EGFR降解的方法，治疗癌症的方法和使肿瘤对放射治疗敏感的方法。
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公开(公告)号：US20240018144A1
公开(公告)日：2024-01-18
申请号：US18031219
申请日：2021-10-12
IPC分类号： C07D471/10
CPC分类号： C07D471/10
摘要： Provided herein are processes for synthesizing compounds useful as EGFR modulators. In particular, provided herein are processes for synthesizing Compound A:
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公开(公告)号：US20230098205A1
公开(公告)日：2023-03-30
申请号：US17908439
申请日：2021-03-05
IPC分类号： C07D239/22 , A61P35/00
摘要： Provided herein are compounds that are useful in treating cancer.
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公开(公告)号：US20220340572A1
公开(公告)日：2022-10-27
申请号：US17739358
申请日：2022-05-09
发明人： Mukesh K. Nyati , Theodore S. Lawrence , Christopher Whitehead , Jason Christopher Rech , Brennan Taylor Watch
IPC分类号： C07D471/10 , C07D233/70 , C07D233/84
摘要： Provided herein are compounds that modulate EGFR and methods of using the same, for example to treat cancer.
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