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1.发明授权公开(公告)号：US08961959B2
公开(公告)日：2015-02-24
申请号：US13652016
申请日：2012-10-15
Applicant: The Regents of the University of Michigan
Inventor： Scott Larsen , Akira Abe , Liming Shu , Michael William Wilson , Richard F. Keep , James A. Shayman
IPC: A61K38/43 , A01N43/36 , A61K31/40 , A61K48/00 , A01N33/18 , A01N33/24 , A61K31/045 , C07D405/00 , C07D207/08 , C07D207/46 , C07D295/04 , A61K45/06 , C07D319/18 , C07D295/125 , C07D295/135
CPC classification number: A61K45/06 , A61K31/40 , C07D295/125 , C07D295/135 , C07D319/18 , A61K2300/00
Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
Abstract translation: 披露了葡糖基神经酰胺合成酶抑制剂及其组合物。 还公开了使用葡萄糖神经酰胺合成酶抑制剂治疗其中抑制葡萄糖神经酰胺合酶有益的疾病和病症的方法，如戈谢病和法布里病。
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公开(公告)号：US10202340B2
公开(公告)日：2019-02-12
申请号：US15546320
申请日：2016-02-01
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Scott D. Larsen , Akira Abe , Liming Shu , Michael William Wilson , Richard F. Keep , Duxin Sun , James A. Shayman
IPC: A61K31/4015 , C07D207/06 , C07D263/20 , C07D207/04 , C07D263/24 , C07D205/04 , C07D207/09 , C07D207/10 , C07D295/125 , C07D295/13
Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
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Patent Agency Ranking
公开(公告)号：US10329283B2
公开(公告)日：2019-06-25
申请号：US15738606
申请日：2016-06-27
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Scott D. Larsen , John J. G. Tesmer , Helen Waldschmidt , Kristoff Homan , Michael William Wilson
IPC: C07D405/14 , C07D401/14 , C07D401/12 , C07D405/12 , A61P9/00 , A61P9/12
Abstract: Disclosed herein are novel GRK inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein the substituents are as described.
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公开(公告)号：US20180022697A1
公开(公告)日：2018-01-25
申请号：US15546320
申请日：2016-02-01
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Scott D. Larsen , Akira Abe , Liming Shu , Michael William Wilson , Richard F. Keep , Duxin Sun , James A. Shayman
IPC: C07D207/06 , C07D263/20 , C07D207/10 , C07D295/13 , C07D205/04
CPC classification number: C07D207/06 , A61K31/4015 , C07D205/04 , C07D207/04 , C07D207/09 , C07D207/10 , C07D263/20 , C07D263/24 , C07D295/125 , C07D295/13
Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
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5.发明公开公开(公告)号：US20230212123A1
公开(公告)日：2023-07-06
申请号：US17920794
申请日：2021-04-20
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Scott D. Larsen , James A. Shayman , Michael William Wilson , Neil Moss
IPC: C07D213/64 , C07D213/65 , C07D213/40 , C07D213/68 , C07D401/06 , C07D213/61 , A61K45/06
CPC classification number: C07D213/64 , A61K45/06 , C07D213/40 , C07D213/61 , C07D213/65 , C07D213/68 , C07D401/06
Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
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公开(公告)号：US20180186779A1
公开(公告)日：2018-07-05
申请号：US15738606
申请日：2016-06-27
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Scott D. Larsen , John J.G. Tesmer , Helen Waldschmidt , Kristoff Homan , Michael William Wilson
IPC: C07D405/14 , C07D405/12 , C07D401/12 , C07D401/14 , A61P9/00 , A61P9/12
CPC classification number: C07D405/14 , A61P9/00 , A61P9/12 , C07D401/12 , C07D401/14 , C07D405/12
Abstract: Disclosed herein are novel GRK inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein the substituents are as described.
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7.发明申请公开(公告)号：US20130095089A1
公开(公告)日：2013-04-18
申请号：US13652016
申请日：2012-10-15
Applicant: The Regents of The University of Michigan
Inventor： Scott Larsen , Akira Abe , Liming Shu , Michael William Wilson , Richard F. Keep , James A. Shayman
IPC: A61K31/4025 , C07D207/09 , A61K31/40 , A61P25/16 , A61P25/00 , A61K48/00 , A61P7/06 , A61P35/00 , A61P13/12 , A61P9/10 , A61P31/00 , A61K38/43 , C07D405/10 , A61P3/10
CPC classification number: A61K45/06 , A61K31/40 , C07D295/125 , C07D295/135 , C07D319/18 , A61K2300/00
Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
Abstract translation: 披露了葡糖基神经酰胺合成酶抑制剂及其组合物。 还公开了使用葡萄糖神经酰胺合成酶抑制剂治疗其中抑制葡萄糖神经酰胺合酶有益的疾病和病症的方法，如戈谢病和法布里病。
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