公开(公告)号：US20190144818A1

公开(公告)日：2019-05-16

申请号：US16300499

申请日：2017-05-11

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Stacy RAMCHARAN ,  Luis SOLORIO ,  Jacob JORDAHL ,  Joerg LAHANN

IPC: C12N5/00

Abstract: A cellular support system comprises a three-dimensional scaffold structure comprising at least one void. At least one suspended protein bridge spans across the at least one void in the three-dimensional scaffold structure. The suspended protein bridge is capable of supporting cells and promotes three-dimensional cellular growth. In certain aspects, the protein in the suspended protein bridge is an extracellular matrix protein, such as collagens, laminins, fibronectins, and combinations thereof. Such a cellular support system supports thriving cell cultures in three-dimensions emulating cell growth in vivo in an extracellular matrix, including promoting cell remodeling. Methods for making such cellular support systems are also provided.