公开(公告)号：US20230062256A1

公开(公告)日：2023-03-02

申请号：US17795581

申请日：2021-01-28

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Xudong FAN ,  Xueding WANG ,  Xuzhou LI ,  Wei ZHANG ,  William Yanli WANG ,  Xiaoqin WU ,  Xiaotian TAN ,  Brendon BAKER ,  Yannis M. PAULUS

IPC分类号： A61B3/12 ,  G01N33/58 ,  A61B3/10 ,  G01N21/47 ,  G01N21/64

摘要： An imaging system for cell-based therapies is provided. The imagining system includes one or more optical tags configured for insertion into a cell or biological tissue, an excitation light source configured to illuminate the one or more optical tags; a detector configured to measure optical emission of the one or more optical tags; an imaging subsystem configured to determine a three-dimensional location of each of the one or more optical tags in the cell or biological tissue; and a controller in electrical communication with the excitation light source, the detector, and the imaging subsystem. Each of the one or more optical tags has a contrasting feature and includes a fluorescent material. The contrasting feature may be defined by at least one of a refractive index, shape, color, and laser emission of each optical tag of the one or more optical tags.