-
公开(公告)号:US11168082B2
公开(公告)日:2021-11-09
申请号:US16611238
申请日:2018-05-15
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor: Shaomeng Wang , Dengyou Zhang , Canhui Zheng , Zhuo Chen , Liu Liu , Liyue Huang , Chao-Yie Yang
IPC: C07D471/04 , A61P35/00 , C07D519/00
Abstract: The present disclosure provides compounds represented by Formula I and II: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, X, W, Y, and Z are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I and II for use to treat a condition or disorder responsive to LSD1 inhibition such as cancer.
-
公开(公告)号:US20200157091A1
公开(公告)日:2020-05-21
申请号:US16611238
申请日:2018-05-15
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor: Shaomeng Wang , Dengyou Zhang , Canhui Zheng , Zhuo Chen , Liu Liu , Liyue Huang , Chao-Yie Yang
IPC: C07D471/04 , C07D519/00
Abstract: The present disclosure provides compounds represented by Formula I and II: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, X, W, Y, and Z are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I and II for use to treat a condition or disorder responsive to LSD1 inhibition such as cancer.
-
公开(公告)号:US11466028B2
公开(公告)日:2022-10-11
申请号:US16332533
申请日:2017-09-13
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor: Shaomeng Wang , Yang Hu , Chong Qin , Fuming Xu , Jiantao Hu , Bing Zhou , Zhuo Chen , Ester Fernandez-Salas , Longchuan Bai , Donna McEachern
IPC: C07D498/14 , A61P35/02 , A61P35/04
Abstract: The present disclosure provides compounds represented by Formula I and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, Ar, L, X, Y, and B are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.
-
公开(公告)号:US20210284657A1
公开(公告)日:2021-09-16
申请号:US16332533
申请日:2017-09-13
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor: Shaomeng Wang , Yang Hu , Chong Qin , Fuming Xu , Jiantao Hu , Bing Zhou , Zhuo Chen , Ester Fernandez-Salas , Longchuan Bai , Donna McEachern
IPC: C07D498/14 , A61P35/04 , A61P35/02
Abstract: The present disclosure provides compounds represented by Formula I and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, Ar, L, X, Y, and B are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.
-
-
-