公开(公告)号：US11168082B2

公开(公告)日：2021-11-09

申请号：US16611238

申请日：2018-05-15

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Dengyou Zhang ,  Canhui Zheng ,  Zhuo Chen ,  Liu Liu ,  Liyue Huang ,  Chao-Yie Yang

IPC: C07D471/04 ,  A61P35/00 ,  C07D519/00

Abstract: The present disclosure provides compounds represented by Formula I and II: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, X, W, Y, and Z are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I and II for use to treat a condition or disorder responsive to LSD1 inhibition such as cancer.

公开(公告)号：US20200157091A1

公开(公告)日：2020-05-21

申请号：US16611238

申请日：2018-05-15

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Dengyou Zhang ,  Canhui Zheng ,  Zhuo Chen ,  Liu Liu ,  Liyue Huang ,  Chao-Yie Yang

IPC: C07D471/04 ,  C07D519/00

Abstract: The present disclosure provides compounds represented by Formula I and II: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, X, W, Y, and Z are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I and II for use to treat a condition or disorder responsive to LSD1 inhibition such as cancer.

公开(公告)号：US11466028B2

公开(公告)日：2022-10-11

申请号：US16332533

申请日：2017-09-13

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Yang Hu ,  Chong Qin ,  Fuming Xu ,  Jiantao Hu ,  Bing Zhou ,  Zhuo Chen ,  Ester Fernandez-Salas ,  Longchuan Bai ,  Donna McEachern

IPC: C07D498/14 ,  A61P35/02 ,  A61P35/04

Abstract: The present disclosure provides compounds represented by Formula I and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, Ar, L, X, Y, and B are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.

公开(公告)号：US20210284657A1

公开(公告)日：2021-09-16

申请号：US16332533

申请日：2017-09-13

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Yang Hu ,  Chong Qin ,  Fuming Xu ,  Jiantao Hu ,  Bing Zhou ,  Zhuo Chen ,  Ester Fernandez-Salas ,  Longchuan Bai ,  Donna McEachern

IPC: C07D498/14 ,  A61P35/04 ,  A61P35/02

Abstract: The present disclosure provides compounds represented by Formula I and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, Ar, L, X, Y, and B are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.