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公开(公告)号:US10526863B2
公开(公告)日:2020-01-07
申请号:US15995777
申请日:2018-06-01
发明人: Peter D. Gabriele , Dennis Shull , Fred B. Pippert
IPC分类号: E21B33/12 , E21B33/134 , E21B43/22 , C08L67/00
摘要: Compositions and methods are beneficial for use in downhole applications, especially oil and gas well bores. A composition includes an elastomer doped with a dopant. The presence of the dopant increases a rate of microbial degradation of the elastomer by a microbe. A method includes forming an article including a doped polymer. The doped polymer includes an elastomer doped with a dopant. The method also includes placing the article in a service environment. The presence of the dopant in the doped polymer increases a rate of microbial degradation of the elastomer by a microbe in the service environment.
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2.
公开(公告)号:US11406732B2
公开(公告)日:2022-08-09
申请号:US17148130
申请日:2021-01-13
发明人: Stephanie Reed , Carissa Smoot , Dennis Shull , Todd Crumbling , John D'Ottavio , Peter D. Gabriele , Jeremy J. Harris , Charles Brendan Nicholson , Jared Ely
摘要: A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.
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3.
公开(公告)号:US10918764B2
公开(公告)日:2021-02-16
申请号:US16547175
申请日:2019-08-21
发明人: Stephanie Reed , Carissa Smoot , Dennis Shull , Todd Crumbling , John D'Ottavio , Peter D. Gabriele , Jeremy J. Harris , Charles Brendan Nicholson , Jared Ely
摘要: A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.
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4.
公开(公告)号:US20240238478A1
公开(公告)日:2024-07-18
申请号:US18425208
申请日:2024-01-29
发明人: Stephanie Reed , Carissa Smoot , Dennis Shull , Todd Crumbling , John D'Ottavio , Peter D. Gabriele , Jeremy J. Harris , Charles Brendan Nicholson , Jared Ely
CPC分类号: A61L27/18 , A61K31/522 , A61L27/54 , B29C67/246 , B33Y80/00 , B29C64/10 , B33Y10/00
摘要: A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.
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5.
公开(公告)号:US11883557B2
公开(公告)日:2024-01-30
申请号:US17662462
申请日:2022-05-09
发明人: Stephanie Reed , Carissa Smoot , Dennis Shull , Todd Crumbling , John D'Ottavio , Peter D. Gabriele , Jeremy J. Harris , Charles Brendan Nicholson , Jared Ely
CPC分类号: A61L27/18 , A61K31/522 , A61L27/54 , B29C67/246 , B33Y80/00 , B29C64/10 , B33Y10/00
摘要: A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.
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6.
公开(公告)号:US20220257828A1
公开(公告)日:2022-08-18
申请号:US17662462
申请日:2022-05-09
发明人: Stephanie Reed , Carissa Smoot , Dennis Shull , Todd Crumbling , John D'Ottavio , Peter D. Gabriele , Jeremy J. Harris , Charles Brendan Nicholson , Jared Ely
IPC分类号: A61L27/18 , A61L27/54 , A61K31/522 , B29C67/24 , B33Y80/00
摘要: A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.
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