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公开(公告)号：US20230126744A1
公开(公告)日：2023-04-27
申请号：US18049535
申请日：2022-10-25
发明人： Jeremy J. HARRIS , Scott RADZINSKI , Brian GINN , Peter D. GABRIELE , Stephanie REED , Benjamin ROADARMEL
IPC分类号： A61K9/16 , A61K31/7105 , A61K31/711
摘要： A polymeric delivery system delivers a biologic to cells. In some embodiments, the polymeric delivery system includes polyplexes. Each polyplex includes at least one charged polymer and at least one biologic. The at least one charged polymer includes a polyester copolymer of a polyol and a polycarboxylic acid modified with at least one charged moiety having an opposite charge from a net charge of the at least one biologic. In other embodiments, the polymeric delivery system includes self-assembled particles including a block copolymer and a biologic associated with the block copolymer. The block copolymer includes a first block of a polyester copolymer of a polyol and a polycarboxylic acid and a second block of a second monomer or a second polymer.
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公开(公告)号：US20220386591A1
公开(公告)日：2022-12-08
申请号：US17805100
申请日：2022-06-02
申请人： THE SECANT GROUP LLC
摘要： A cryopreservation process includes combining a cryopreservation composition with a biological sample. The cryopreservation composition includes at least one glycerol ester component. The cryopreservation process also includes then cooling the cryopreservation composition with the biological sample to a cryopreservation temperature. The cryopreservation composition aids in cryopreserving the biological sample at the cryopreservation temperature. A cryopreservation composition includes at least one glycerol ester component. A cryopreserved system includes a biological sample in a cryopreservation composition at a cryopreservation temperature. The cryopreservation composition includes at least one glycerol ester component.
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公开(公告)号：US20210317278A1
公开(公告)日：2021-10-14
申请号：US17226718
申请日：2021-04-09
摘要： In some embodiments, a polymer film includes a base composition of poly(ethylene-vinyl acetate) and a surface composition comprising hydroxy groups. In some embodiments, a polymer film includes a base layer of a first composition of poly(ethylene-vinyl acetate), a surface layer at a surface of the base layer, and a coating layer of a second composition of a copolymer of glycerol and sebacic acid. The surface layer includes surface hydroxy groups converted from acetate groups of the poly(ethylene-vinyl acetate). The second composition is attached to the surface layer by ester bonds between carboxyl groups of the copolymer and the hydroxy groups. A single-use bioreactor bag includes a polymer film including a base composition of poly(ethylene-vinyl acetate) and a surface composition comprising hydroxy groups. A method of modifying a poly(ethylene-vinyl acetate) film includes converting acetate groups at a first surface of the poly(ethylene-vinyl acetate) film to hydroxy groups.
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公开(公告)号：US20240109981A1
公开(公告)日：2024-04-04
申请号：US18534899
申请日：2023-12-11
IPC分类号： C08F2/10 , C08F2/50 , C08F120/14
CPC分类号： C08F2/10 , C08F2/50 , C08F120/14 , C08F2438/02 , C08G63/20
摘要： A water-mediated process prepares a polymeric (meth)acrylation composition. In some embodiments, the process includes providing a stabilized aqueous solution including a (meth)acrylation component and a polyol monomer in a vessel under an inert atmosphere and adding a diacid monomer to the vessel under the inert atmosphere. In some embodiments, the process includes providing a stabilized aqueous solution including a (meth)acrylation component and a copolymer of a polyol monomer and a diacid monomer in a vessel under an inert atmosphere. The process further includes heating and removing water from the vessel under the inert atmosphere to produce the polymeric (meth)acrylation composition. The polymeric (meth)acrylation composition includes a (meth)acrylation polyester copolymer of the diacid monomer and the polyol monomer with the (meth)acrylation component conjugated to the (meth)acrylation polyester copolymer. In some embodiments, the polymeric (meth)acrylation composition is free of mineral acid and free of cytotoxic solvents, catalysts, and scavengers.
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公开(公告)号：US20210309766A1
公开(公告)日：2021-10-07
申请号：US17223722
申请日：2021-04-06
IPC分类号： C08F2/10 , C08F120/14 , C08F2/50
摘要： A water-mediated process prepares a polymeric (meth)acrylation composition. In some embodiments, the process includes providing a stabilized aqueous solution including a (meth)acrylation component and a polyol monomer in a vessel under an inert atmosphere and adding a diacid monomer to the vessel under the inert atmosphere. In some embodiments, the process includes providing a stabilized aqueous solution including a (meth)acrylation component and a copolymer of a polyol monomer and a diacid monomer in a vessel under an inert atmosphere. The process further includes heating and removing water from the vessel under the inert atmosphere to produce the polymeric (meth)acrylation composition. The polymeric (meth)acrylation composition includes a (meth)acrylation polyester copolymer of the diacid monomer and the polyol monomer with the (meth)acrylation component conjugated to the (meth)acrylation polyester copolymer. In some embodiments, the polymeric (meth)acrylation composition is free of mineral acid and free of cytotoxic solvents, catalysts, and scavengers.
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