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公开(公告)号：US20220386591A1
公开(公告)日：2022-12-08
申请号：US17805100
申请日：2022-06-02
申请人： THE SECANT GROUP LLC
摘要： A cryopreservation process includes combining a cryopreservation composition with a biological sample. The cryopreservation composition includes at least one glycerol ester component. The cryopreservation process also includes then cooling the cryopreservation composition with the biological sample to a cryopreservation temperature. The cryopreservation composition aids in cryopreserving the biological sample at the cryopreservation temperature. A cryopreservation composition includes at least one glycerol ester component. A cryopreserved system includes a biological sample in a cryopreservation composition at a cryopreservation temperature. The cryopreservation composition includes at least one glycerol ester component.
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公开(公告)号：US20210317278A1
公开(公告)日：2021-10-14
申请号：US17226718
申请日：2021-04-09
摘要： In some embodiments, a polymer film includes a base composition of poly(ethylene-vinyl acetate) and a surface composition comprising hydroxy groups. In some embodiments, a polymer film includes a base layer of a first composition of poly(ethylene-vinyl acetate), a surface layer at a surface of the base layer, and a coating layer of a second composition of a copolymer of glycerol and sebacic acid. The surface layer includes surface hydroxy groups converted from acetate groups of the poly(ethylene-vinyl acetate). The second composition is attached to the surface layer by ester bonds between carboxyl groups of the copolymer and the hydroxy groups. A single-use bioreactor bag includes a polymer film including a base composition of poly(ethylene-vinyl acetate) and a surface composition comprising hydroxy groups. A method of modifying a poly(ethylene-vinyl acetate) film includes converting acetate groups at a first surface of the poly(ethylene-vinyl acetate) film to hydroxy groups.
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公开(公告)号：US20210024686A1
公开(公告)日：2021-01-28
申请号：US17065971
申请日：2020-10-08
IPC分类号： C08G63/12 , A61K47/55 , C08G63/81 , C08G63/133 , C08G63/123 , C08G63/06 , C08G63/78
摘要： A method includes combining an alcohol-pharmaceutical conjugate, a polyol, and an aqueous liquid in a vessel. The alcohol-pharmaceutical conjugate includes a pharmaceutical compound having at least one carboxyl group attached to the polyol by an ester bond. The method also includes adding an acid monomer to the vessel and heating and removing water from the vessel to produce the polymeric material. The polymeric material includes a polyester copolymer of the acid monomer and the polyol and the pharmaceutical compound.
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公开(公告)号：US20200179513A1
公开(公告)日：2020-06-11
申请号：US16780177
申请日：2020-02-03
发明人： Peter D. GABRIELE , Jared ELY , Jeremy J. HARRIS
摘要： A method of cancer hyperthermia therapy includes placing a device including an exogenously-excitable polymeric material at a cancer hyperthermia therapy site of a patient. The method also includes supplying an exogenous energy to the device such that the exogenous energy excites the exogenously-excitable polymeric material at the cancer hyperthermia therapy site to heat the cancer hyperthermia therapy site to a hyperthermia temperature. A method of preparing a polymeric material includes combining an alcohol monomer, a seed of the polymeric material, and an aqueous liquid in a vessel. The method also includes adding an acid monomer to the vessel and supplying an exogenous energy to the vessel. The polymeric material is exogenously excited by the exogenous energy to heat the polymeric material. The method further includes removing water from the vessel and producing the polymeric material, which is a polyester, in the vessel.
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公开(公告)号：US20200157493A1
公开(公告)日：2020-05-21
申请号：US16691040
申请日：2019-11-21
摘要： A engineered textile construction includes a first textile having a first average pore size forming a textile cell growth matrix in which the first textile is a woven or a knit construction, the textile cell growth matrix is configured to have a surface area sufficient to promote cell expansion and the first average pore size is preselected to prevent filling of the pores during cell expansion.
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6.发明申请公开(公告)号：US20200061240A1
公开(公告)日：2020-02-27
申请号：US16547175
申请日：2019-08-21
发明人： Stephanie REED , Carissa SMOOT , Dennis SHULL , Todd CRUMBLING , John D'OTTAVIO , Peter D. GABRIELE , Jeremy J. HARRIS , Charles Brendan NICHOLSON , Jared ELY
IPC分类号： A61L27/18 , A61L27/54 , A61K31/522 , B33Y80/00 , B29C67/24
摘要： A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.
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公开(公告)号：US20190105148A1
公开(公告)日：2019-04-11
申请号：US16153219
申请日：2018-10-05
摘要： A composite lumen includes an extruded tube of a composite including a poly(glycerol sebacate) (PGS) matrix mixed with a PGS thermoset filler. The composite lumen also includes an overbraid structure overlying an outer surface of the extruded tube. A method of forming a composite lumen includes extruding a PGS tube of a composite including a PGS matrix mixed with a PGS thermoset filler. The method also includes applying an overbraid structure over an outer surface of the extruded tube.
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公开(公告)号：US20230126744A1
公开(公告)日：2023-04-27
申请号：US18049535
申请日：2022-10-25
发明人： Jeremy J. HARRIS , Scott RADZINSKI , Brian GINN , Peter D. GABRIELE , Stephanie REED , Benjamin ROADARMEL
IPC分类号： A61K9/16 , A61K31/7105 , A61K31/711
摘要： A polymeric delivery system delivers a biologic to cells. In some embodiments, the polymeric delivery system includes polyplexes. Each polyplex includes at least one charged polymer and at least one biologic. The at least one charged polymer includes a polyester copolymer of a polyol and a polycarboxylic acid modified with at least one charged moiety having an opposite charge from a net charge of the at least one biologic. In other embodiments, the polymeric delivery system includes self-assembled particles including a block copolymer and a biologic associated with the block copolymer. The block copolymer includes a first block of a polyester copolymer of a polyol and a polycarboxylic acid and a second block of a second monomer or a second polymer.
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公开(公告)号：US20210179993A1
公开(公告)日：2021-06-17
申请号：US17125146
申请日：2020-12-17
摘要： A modular flow-through cartridge bioreactor system includes a plurality of modular flow-through cartridges. Each modular flow-through cartridge includes a cartridge housing with ports for through flow of a biological media and predetermined contents preloaded in the cartridge housing permitting the cartridge to perform at least one predetermined function of the bioreactor process upon through-flow of the biological media. The modular flow-through cartridge bioreactor system also includes at least one interlock connector fluidly connecting the plurality of modular flow-through cartridges by the ports. A modular flow through cartridge includes rows of porous textiles preloaded in the cartridge housing. A process includes selecting a plurality of modular flow-through cartridges to perform, in combination, a bioreactor process. The process also includes fluidly connecting the modular flow-through cartridges in a fluid sequence to form the modular flow-through cartridge bioreactor system. Flowing the biological media through the fluid sequence performs the bioreactor process.
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公开(公告)号：US20210060214A1
公开(公告)日：2021-03-04
申请号：US17006129
申请日：2020-08-28
摘要： An article includes a fibrous mat of poly(glycerol sebacate) (PGS) resin and a resin of a hydrogel forming polymer, such as a polyvinyl alcohol (PVOH). Methods of making such articles include electrospinning a combination of PGS resin and PVOH resin to form nanofibers and depositing the nanofibers onto a surface to form the fibrous mat. The mat is suitable for a variety of medical uses, including as a barrier that can be deployed in surgical procedures.
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