公开(公告)号：US20200319180A1

公开(公告)日：2020-10-08

申请号：US16906669

申请日：2020-06-19

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Virginia Wood Cornish ,  Nili Ostrov ,  Miguel Jimenez ,  Sonja Billerbeck

IPC分类号： G01N33/566 ,  C12Q1/02 ,  G01N33/74 ,  G01N33/50 ,  C12Q1/00 ,  C12Q1/06 ,  G01N33/569

摘要： The present invention provides sensor cells comprising a receptor that binds to an analyte indicative of the presence of an agent, where binding of the analyte to the receptor triggers a detection event that is indicative of the presence of the agent. In certain embodiments, the detection event is appearance of a reporter detectable by the naked eye. The present invention also provides uses of such sensor cells for detecting the presence of an agent in a sample.

公开(公告)号：US10725036B2

公开(公告)日：2020-07-28

申请号：US15596837

申请日：2017-05-16

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Virginia Wood Cornish ,  Nili Ostrov ,  Miguel Jimenez ,  Sonja Billerbeck

IPC分类号： G01N33/566 ,  C12Q1/02 ,  C12Q1/00 ,  C12Q1/06 ,  G01N33/569 ,  G01N33/74 ,  G01N33/50

摘要： The present invention provides sensor cells comprising a receptor that binds to an analyte indicative of the presence of an agent, where binding of the analyte to the receptor triggers a detection event that is indicative of the presence of the agent. In certain embodiments, the detection event is appearance of a reporter detectable by the naked eye. The present invention also provides uses of such sensor cells for detecting the presence of an agent in a sample.

公开(公告)号：US11899014B2

公开(公告)日：2024-02-13

申请号：US16906669

申请日：2020-06-19

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Virginia Wood Cornish ,  Nili Ostrov ,  Miguel Jimenez ,  Sonja Billerbeck

IPC分类号： G01N33/566 ,  C12Q1/02 ,  G01N33/74 ,  G01N33/50 ,  C12Q1/00 ,  C12Q1/06 ,  G01N33/569

CPC分类号： G01N33/566 ,  C12Q1/005 ,  C12Q1/02 ,  C12Q1/025 ,  C12Q1/06 ,  G01N33/5023 ,  G01N33/5038 ,  G01N33/569 ,  G01N33/5695 ,  G01N33/56911 ,  G01N33/56916 ,  G01N33/56961 ,  G01N33/74 ,  G01N2333/726

摘要： The present invention provides sensor cells comprising a receptor that binds to an analyte indicative of the presence of an agent, where binding of the analyte to the receptor triggers a detection event that is indicative of the presence of the agent. In certain embodiments, the detection event is appearance of a reporter detectable by the naked eye. The present invention also provides uses of such sensor cells for detecting the presence of an agent in a sample.

公开(公告)号：US20170336407A1

公开(公告)日：2017-11-23

申请号：US15596837

申请日：2017-05-16

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： VIRGINIA WOOD CORNISH ,  Nili Ostrov ,  Miguel Jimenez ,  Sonja Billerbeck

IPC分类号： G01N33/566 ,  C12Q1/02 ,  G01N33/50 ,  C12Q1/06 ,  G01N33/569 ,  C12Q1/00

摘要： The present invention provides sensor cells comprising a receptor that binds to an analyte indicative of the presence of an agent, where binding of the analyte to the receptor triggers a detection event that is indicative of the presence of the agent. In certain embodiments, the detection event is appearance of a reporter detectable by the naked eye. The present invention also provides uses of such sensor cells for detecting the presence of an agent in a sample.