公开(公告)号：US12257066B2

公开(公告)日：2025-03-25

申请号：US17290991

申请日：2019-11-01

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Jonathan Thomas Elliott ,  Ida Leah Gitajn ,  Shudong Jiang ,  Brian Pogue

IPC: A61B17/80 ,  A61B5/00

Abstract: An ORIF implant has an electronics module with a stimulus light and optical sensors for sensing fluorescent emissions coupled to a near-field digital radio. The implant is used with a near-field radio to receive a sequence of fluorescent emissions readings from the implant into a processor that fits the sequence of readings to a bone-specific kinetic model that is a superposition of a plug flow model of periosteal perfusion and a two-compartment model of endosteal perfusion of perfusion of bone. A system for use during ORIF surgery has an injector for fluorescent dye, a camera to send a sequence of images of fluorescent emissions from fluorescent dye in a bone of a subject to an image processor when the bone is illuminated with a stimulus light, the processor configured to fit the sequence of images to a model of perfusion of bone.