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公开(公告)号：US12257066B2
公开(公告)日：2025-03-25
申请号：US17290991
申请日：2019-11-01
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Jonathan Thomas Elliott , Ida Leah Gitajn , Shudong Jiang , Brian Pogue
Abstract: An ORIF implant has an electronics module with a stimulus light and optical sensors for sensing fluorescent emissions coupled to a near-field digital radio. The implant is used with a near-field radio to receive a sequence of fluorescent emissions readings from the implant into a processor that fits the sequence of readings to a bone-specific kinetic model that is a superposition of a plug flow model of periosteal perfusion and a two-compartment model of endosteal perfusion of perfusion of bone. A system for use during ORIF surgery has an injector for fluorescent dye, a camera to send a sequence of images of fluorescent emissions from fluorescent dye in a bone of a subject to an image processor when the bone is illuminated with a stimulus light, the processor configured to fit the sequence of images to a model of perfusion of bone.
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公开(公告)号：US12196894B2
公开(公告)日：2025-01-14
申请号：US17796488
申请日：2021-01-29
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE , DOSEOPTICS, LLC
Inventor： Petr Bruza , Brian Pogue , Venkataramanan Krishnaswamy
Abstract: A Cherenkov imaging system includes a high-speed radiation detector configured to provide a first timing signal synchronized with pulses of radiation to control operation of at least one pulse-gated, multiple-pulse-integrating, (PG-MPI) CMOS camera synchronized through the digital time signal to pulses of the radiation beam source, to image Cherenkov radiation; and a digital image-processing system. The high-speed radiation detector is either a solid-state radiation detector or a scintillator with a photodetector. The system images Cherenkov light emitted by tissue by using a timing signal synchronized to pulses of a pulsed radiation beam to control the PG-MPI camera by integrating light received by the PG-MPI camera during multiple pulses of the radiation beam while excluding light received by the camera between pulses of the radiation beam.
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Patent Agency Ranking
3.发明授权公开(公告)号：US12029922B2
公开(公告)日：2024-07-09
申请号：US17627633
申请日：2020-07-15
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Rachael Hachadorian , Brian Pogue , Petr Bruza , Lesley Jarvis
CPC classification number: A61N5/1071 , A61N5/10 , A61N5/103 , A61N5/1039 , A61N5/1048 , A61N5/1049 , G01T1/22 , G01T1/2992 , A61N2005/1055 , A61N2005/1059 , A61N2005/1061 , A61N2005/1087 , A61N2005/1089
Abstract: A system for monitoring radiation treatment images Cherenkov emissions from tissue of a subject. A processor of the system determines densities of a surface layer of the subject from 3D images of the tissue to determine correction factors. The processor uses these factors to correct the Cherenkov images for attenuation of Cherenkov light by tissue, making them proportional to radiation dose. In embodiments, the system obtains reflectance images of the subject, determines second correction factors therefrom, and applies the second correction factors to the Cherenkov emissions images. In embodiments, the corrected images of Cherenkov emissions are compared to dose maps of a treatment plan. A method of correcting Cherenkov emissions images includes determining tissue characteristics from CT or MRI images in a surface volume where Cherenkov is expected, using; imaging Cherenkov emissions; and using the tissue characteristics to correct the images for variations in Cherenkov light propagation through the tissue.
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公开(公告)号：US11633145B2
公开(公告)日：2023-04-25
申请号：US17076788
申请日：2020-10-21
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Brian Pogue , Samuel Streeter , Benjamin Maloney , Keith Paulsen
Abstract: A surgical specimen imaging system includes a micro-X-ray computed tomography (CT) unit for CT imaging of the specimen and a structured light imaging (SLI) unit for optical imaging at multiple wavelengths, multiple phase offsets, and multiple structured-light pattern periods including unstructured light. The system's image processing unit receives CT and optical images and is configured by firmware in memory to co-register the images and process the optical images to determine texture at multiple subimages of the optical images, determined textures forming a texture map. The texture map is processed by a machine-learning-based classifier to determine a tissue type map of the specimen, and the tissue type map is processed with the CT images to give a 3D tissue-type map. In embodiments, the firmware extracts optical properties including scattering and absorption at multiple wavelengths and the classifier also uses these properties in generating the tissue type map.
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公开(公告)号：US12036421B2
公开(公告)日：2024-07-16
申请号：US18563813
申请日：2022-05-25
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Petr Bruza , Brian Pogue , Ramish Ashraf , Rongxiao Zhang , David Gladstone , Megan Clark , Roman Vasyltsiv
IPC: A61N5/10
CPC classification number: A61N5/1031 , A61N5/1049 , A61N5/1067 , A61N5/1071 , A61N2005/1059
Abstract: A system for delivering ultra-high dose rate irradiation to a target area of a patient, includes a pulsed charged-particle source along a beam axis; a collimator for shaping the beam of radiation; one or more cameras for imaging the target area of the patient; and a dosimetry controller for providing control signals to the charged-particle source one or more dosimeters positioned between an output of the charged-particle source and the collimator in beam fringes for measuring a radiation dosage provided by each pulse; and a beam scanning coil positioned between the collimator and the patient for directing the shaped beam. The dosimetry controller receives feedback from the one or more dosimeters and provides control signals to the particle source and the beam scanning coil that modulate final pulses in the series of pulses in real-time.
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公开(公告)号：US11771323B2
公开(公告)日：2023-10-03
申请号：US17794297
申请日：2021-11-15
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Petr Bruza , Brian Pogue
CPC classification number: A61B5/0071 , G01N21/6408 , G01N21/6458
Abstract: A system and method for depth-resolved imaging of fluorophore concentrations in tissue uses a pulsed light source stimulus wavelength to illuminate the tissue; and a time-gated electronic camera such as a single-photon avalanche detector camera to observe the tissue in multiple time windows after start of each light pulse. A filter-changer or tunable filter is between the tissue and the electronic camera with fluorescent imaging settings and a stimulus wavelength setting, and an image processor receives reflectance images and fluorescent emissions images from the time-gated camera and processes these images into depth and quantity resolved images of fluorophore concentrations in the tissue.
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公开(公告)号：US20210113146A1
公开(公告)日：2021-04-22
申请号：US17076788
申请日：2020-10-21
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Brian Pogue , Samuel Streeter , Benjamin Maloney , Keith Paulsen
Abstract: A surgical specimen imaging system includes a micro-X-ray computed tomography (CT) unit for CT imaging of the specimen and a structured light imaging (SLI) unit for optical imaging at multiple wavelengths, multiple phase offsets, and multiple structured-light pattern periods including unstructured light. The system's image processing unit receives CT and optical images and is configured by firmware in memory to co-register the images and process the optical images to determine texture at multiple subimages of the optical images, determined textures forming a texture map. The texture map is processed by a machine-learning-based classifier to determine a tissue type map of the specimen, and the tissue type map is processed with the CT images to give a 3D tissue-type map. In embodiments, the firmware extracts optical properties including scattering and absorption at multiple wavelengths and the classifier also uses these properties in generating the tissue type map.
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