公开(公告)号：US12257066B2

公开(公告)日：2025-03-25

申请号：US17290991

申请日：2019-11-01

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Jonathan Thomas Elliott ,  Ida Leah Gitajn ,  Shudong Jiang ,  Brian Pogue

IPC: A61B17/80 ,  A61B5/00

Abstract: An ORIF implant has an electronics module with a stimulus light and optical sensors for sensing fluorescent emissions coupled to a near-field digital radio. The implant is used with a near-field radio to receive a sequence of fluorescent emissions readings from the implant into a processor that fits the sequence of readings to a bone-specific kinetic model that is a superposition of a plug flow model of periosteal perfusion and a two-compartment model of endosteal perfusion of perfusion of bone. A system for use during ORIF surgery has an injector for fluorescent dye, a camera to send a sequence of images of fluorescent emissions from fluorescent dye in a bone of a subject to an image processor when the bone is illuminated with a stimulus light, the processor configured to fit the sequence of images to a model of perfusion of bone.

公开(公告)号：US20160263402A1

公开(公告)日：2016-09-15

申请号：US15160576

申请日：2016-05-20

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Rongxiao Zhang ,  Brian William Pogue ,  Adam K. Glaser ,  David J. Gladstone ,  Lesley A. Jarvis ,  Jacqueline M. Andreozzi ,  Shudong Jiang ,  Scott Christian Davis ,  Johan Jakob Axelsson

IPC: A61N5/10

CPC classification number: A61N5/1071 ,  A61N5/1049 ,  A61N5/1065 ,  A61N5/1077 ,  A61N2005/1054 ,  A61N2005/1059

Abstract: A monitor for pulsed high energy radiation therapy using a radiation beam passing through a treatment zone, the radiation of 0.2 MEV or greater; has a camera for imaging Cherenkov light from the treatment zone; apparatus for preventing interference by room lighting, the camera synchronized to pulses of the radiation beam; and an image processor adapted to determine extent of the beam area on the patient skin from the images. Additionally an image processor determines cumulative skin dose in the treatment zone from the images. In embodiments, the processor uses a three-dimensional model of a subject to determine mapping of image intensity in images of Cherenkov light to radiation intensity in skin, applies the mapping to images of Cherenkov light to verify skin dose delivered, and accumulates skin dose by summing the maps of skin dose.

Abstract translation: 使用穿过治疗区域的辐射束进行脉冲高能量放射治疗的监测仪，0.2MEV或更大的辐射; 有一个摄像头，用于对来自治疗区的切伦科夫灯进行成像; 用于防止室内照明干扰的装置，照相机与辐射束的脉冲同步; 以及图像处理器，适于从图像确定患者皮肤上的束区域的范围。 此外，图像处理器从图像确定处理区域中的累积皮肤剂量。 在实施例中，处理器使用对象的三维模型来确定切伦科夫光图像中的图像强度与皮肤中的辐射强度的映射，将切布伦科夫光图像应用于图像以验证皮肤剂量递送，并且通过 总结皮肤剂量图。

公开(公告)号：US20210353778A1

公开(公告)日：2021-11-18

申请号：US17322577

申请日：2021-05-17

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Xiaoxin Wang ,  Jifeng Liu ,  Shudong Jiang

IPC: A61K49/00 ,  A61B5/00

Abstract: A phosphor excitable by X-ray and blue-light emits light in the near-infrared (NIR-II, 1000-1700 nanometers) forms nanoparticles less than 200 nanometers diameter. The nanoparticles are tagged by coating with silica, then conjugating with polyethylene glycol (PEG) and tissue-selective compounds such as antibodies, nucleic acid chains, and other ligands. In embodiments, we administer the tagged nanoparticles to a subject, then localize the nanoparticles, and thus antigen-bearing tissues, by irradiating the subject with X-ray or other radiation beams while imaging near infrared light emitted from the subject. The nanoparticles are made by mixing 1-50 micron calcium oxide and germanium oxide powders with dilute nitric acid, adding chromium (III) nitrate at a ratio to germanium between 0.001 and 0.1, adding tartaric acid solution with molar ratio to metal ions between 1-10, and adjusting pH to 0.1-4 with nitric acid, then later heating to form a sol, oven drying, and calcinating the sol.

公开(公告)号：US10940332B2

公开(公告)日：2021-03-09

申请号：US15160576

申请日：2016-05-20

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Rongxiao Zhang ,  Brian William Pogue ,  Adam K. Glaser ,  David J. Gladstone ,  Lesley A. Jarvis ,  Jacqueline M. Andreozzi ,  Shudong Jiang ,  Scott Christian Davis ,  Johan Jakob Axelsson

IPC: A61B5/05 ,  A61B5/00 ,  A61N5/10

Abstract: A monitor for pulsed high energy radiation therapy using a radiation beam passing through a treatment zone, the radiation of 0.2 MEV or greater; has a camera for imaging Cherenkov light from the treatment zone; apparatus for preventing interference by room lighting, the camera synchronized to pulses of the radiation beam; and an image processor adapted to determine extent of the beam area on the patient skin from the images. Additionally an image processor determines cumulative skin dose in the treatment zone from the images. In embodiments, the processor uses a three-dimensional model of a subject to determine mapping of image intensity in images of Cherenkov light to radiation intensity in skin, applies the mapping to images of Cherenkov light to verify skin dose delivered, and accumulates skin dose by summing the maps of skin dose.