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公开(公告)号：US20240115740A1
公开(公告)日：2024-04-11
申请号：US18254851
申请日：2021-11-30
发明人： Andrew TSOURKAS , Feifan YU
CPC分类号： A61K49/0032 , A61K49/0056 , A61K49/16 , C07K16/2863 , C07K16/32 , A61K2123/00
摘要： This invention relates to the compositions and methods for labeling antibodies and other proteins and targeting agents with a helical bundle protein that is functionalized with cargo. Cargos can include but are not limited to fluorescent dyes, haptens (e.g. biotin), contrast agents (e.g. gadolinium, radionuclides), chelated metals, therapeutic agents, sensitizers, or other small molecules. Specifically, provided herein are compositions having a helical bundle, that has been labeled at precisely defined locations with cargo, and that can be conjugated, attached or fused to an antibody or other targeting agent.
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公开(公告)号：US20220235145A1
公开(公告)日：2022-07-28
申请号：US17588205
申请日：2022-01-28
发明人： Andrew TSOURKAS , Burcin ALTUN , Hejia Henry WANG , Feifan YU
摘要： The invention relates to proximity-based sortase-mediated protein purification and ligation. Specifically, the invention relates to techniques that links protein expression/purification with conjugation to therapeutic agents, imaging agents, or linkers.
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公开(公告)号：US20200277403A1
公开(公告)日：2020-09-03
申请号：US16333196
申请日：2017-09-14
发明人： Andrew TSOURKAS , Burcin ALTUN , Hejia Henry WANG , Feifan YU
摘要： The invention relates to proximity-based sortase-mediated protein purification and ligation. Specifically, the invention relates to techniques that links protein expression/purification with conjugation to therapeutic agents, imaging agents, or linkers.
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