公开(公告)号：US20160039852A1

公开(公告)日：2016-02-11

申请号：US14781661

申请日：2014-04-01

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Robert Graham-Goodwin Russell ,  Ilaria Bellantuono

IPC: C07F9/6506 ,  A61Q17/04 ,  A61K8/55 ,  A61K45/06 ,  C07F9/6561 ,  A61K31/675

CPC classification number: C07F9/6506 ,  A61K8/55 ,  A61K31/663 ,  A61K31/675 ,  A61K45/06 ,  A61Q17/04 ,  C07F9/3873 ,  C07F9/5765 ,  C07F9/58 ,  C07F9/6561 ,  A61K2300/00

Abstract: The invention relates to a bisphosphonate (BP) compound, or a pharmaceutically acceptable salt or solvate or prodrug thereof, for use as a cytoprotectant for protecting non-cancerous cells of a subject against radiation-induced damage and/or damage induced by a chemical agent.

Abstract translation: 本发明涉及双膦酸盐（BP）化合物或其药学上可接受的盐或溶剂合物或前药，用作保护受试者的非癌细胞免受由化学试剂引起的辐射诱发的损伤和/或损伤的细胞保护剂 。