公开(公告)号：US20190194746A1

公开(公告)日：2019-06-27

申请号：US16083347

申请日：2017-03-09

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Takeshi Wada ,  Reijiro Yoshino ,  Rintaro Hara ,  Yohei Nukaga

IPC: C12Q1/6876 ,  C12Q1/6853 ,  C07H21/04

CPC classification number: C12Q1/6876 ,  A61K31/7088 ,  A61K48/00 ,  C07H21/04 ,  C12N15/00 ,  C12N15/113 ,  C12Q1/6853 ,  C12Q2527/101 ,  C12Q2527/107 ,  C12Q2600/166

Abstract: A nucleic acid oligomer for RNA hybrid formation, including a structure formed of from 3 to 50 continuous units of at least one unit of a nucleotide unit represented by the following General Formula (1) or a nucleotide unit represented by the following General Formula (2); and having a base length of from 8 bases to 50 bases: in which in the formulae, R1 represents a hydrogen atom, an alkoxy group, an alkenyloxy group, an acyloxy group, a trialkylsilyloxy group, or a halogenyl group, and, in the formulae, each Bs1 independently represents a pyrimidine base that may have a protecting group, a hydrogen atom bonded to a carbon atom at the 5-position of the pyrimidine base may be substituted with a group other than a hydrogen atom, in the formulae, each X independently represents S−Z+ or BH3—Z+, Z+ represents a counter cation, each R2 and R3 independently represents a hydrogen atom, or an alkyl group having from 1 to 10 carbon atoms, and R2 and R3 may be bonded to each other to form a ring.