公开(公告)号：US20240100098A1

公开(公告)日：2024-03-28

申请号：US18264396

申请日：2022-02-16

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Yoshikazu HIGAMI ,  Masaki KOBAYASHI ,  Takumi NARITA ,  Kanari TAKI ,  Yuto HIRAO

IPC: A61K35/28 ,  A01K67/027 ,  A61K35/35

CPC classification number: A61K35/28 ,  A01K67/0276 ,  A61K35/35 ,  A01K2267/025

Abstract: A non-human animal or a part of the same in which the function of Mipep gene is totally or partially lost in adipose tissues or the expression level of Mipep gene in adipose tissues is lowered compared to a wild type; and mesenchymal stem cells or adipocytes in which the function of Mipep gene is totally or partially lost or the expression level of Mipep gene is lowered compared to a wild type. A therapeutic or prophylactic drug that includes the mesenchymal stem cells or adipocytes or a culture supernatant thereof; and a method for preparing a mitokine mixture using the non-human cells, mesenchymal stem cells or adipocytes.