公开(公告)号：US20220204459A1

公开(公告)日：2022-06-30

申请号：US17557751

申请日：2021-12-21

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION ,  JEOL Ltd.

Inventor： Tatsuya Higashi ,  Shoujiro Ogawa ,  Masaki Takiwaki ,  Seketsu Fukuzawa

IPC: C07D249/12

Abstract: A compound represented by Chemical formula 1: wherein n is an integer of 2 or more, is provided. Also provided is a derivatization reagent for derivatizing a diene-containing compound, including a compound represented by Chemical formula 1. Further provided is a synthesis method for a compound, including a nucleophilic substitution reaction between an aryl halide and a heterocyclic amine compound being saturated, the compound being represented by Chemical formula 1.

公开(公告)号：US11718590B2

公开(公告)日：2023-08-08

申请号：US17557751

申请日：2021-12-21

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION ,  JEOL Ltd.

Inventor： Tatsuya Higashi ,  Shoujiro Ogawa ,  Masaki Takiwaki ,  Seketsu Fukuzawa

IPC: C07D249/12

CPC classification number: C07D249/12

Abstract: A compound represented by Chemical formula 1:




wherein n is an integer of 2 or more, is provided. Also provided is a derivatization reagent for derivatizing a diene-containing compound, including a compound represented by Chemical formula 1. Further provided is a synthesis method for a compound, including a nucleophilic substitution reaction between an aryl halide and a heterocyclic amine compound being saturated, the compound being represented by Chemical formula 1.

公开(公告)号：US20240110922A1

公开(公告)日：2024-04-04

申请号：US18241473

申请日：2023-09-01

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION ,  JEOL Ltd.

Inventor： Tatsuya Higashi ,  Masaki Takiwaki ,  Koji Takahashi ,  Seketsu Fukuzawa

IPC: G01N33/68

CPC classification number: G01N33/6848

Abstract: An estrogen derivatization method uses a quaternary cation-containing 5-fluoro-2,4-dinitrophenyl compound represented by Formula (1):






where in Formula (1), X is a quaternary cation. A mass spectrometry method includes derivatizing estrogen by the above estrogen derivatization method. A derivatization reagent derivatizing estrogen includes a quaternary cation-containing 5-fluoro-2,4-dinitrophenyl compound represented by Formula (1), where in Formula (1), X is a quaternary cation.

公开(公告)号：US11193948B2

公开(公告)日：2021-12-07

申请号：US15813542

申请日：2017-11-15

Applicant: Tokyo University of Science ,  National University Corporation Chiba University ,  JEOL Ltd.

Inventor： Tatsuya Higashi ,  Shoujiro Ogawa ,  Fumio Nomura ,  Mamoru Satoh ,  Masaki Takiwaki

IPC: G01N33/82 ,  G01N30/72

Abstract: Provided is a method for quantifying vitamin D, with the vitamin D contained in a biological sample being derivatized with a derivatization reagent and being measured with a mass spectrometer, the method including, a derivatization step of derivatizing n number of samples by using n types of 4-(4′-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues respectively as derivatization reagents, a mixing step of mixing the n types of derivatization samples obtained in the derivatization step, and a quantitative analysis step of subjecting each of the n types of vitamin D derivatives contained in the mixed sample obtained in the mixing step to quantitative analysis using a mass spectrometer.

公开(公告)号：US10761102B2

公开(公告)日：2020-09-01

申请号：US15718809

申请日：2017-09-28

Applicant: Tokyo University of Science ,  National University Corporation Chiba University ,  JEOL Ltd.

Inventor： Tatsuya Higashi ,  Shoujiro Ogawa ,  Fumio Nomura ,  Mamoru Satoh ,  Masaki Takiwaki

IPC: G01N33/82 ,  G01N30/06 ,  G01N33/58

Abstract: Provided is a method for derivatizing an s-cis-diene compound with a Cookson-type derivatization reagent, the method including adding, in a reaction stopping step of stopping a derivatization reaction of the s-cis-diene compound, a decomposition inhibitor to inhibit decomposition of a derivative to be obtained.

公开(公告)号：US20180136240A1

公开(公告)日：2018-05-17

申请号：US15813542

申请日：2017-11-15

Applicant: Tokyo University of Science ,  National University Corporation Chiba University ,  JEOL Ltd.

Inventor： Tatsuya Higashi ,  Shoujiro Ogawa ,  Fumio Nomura ,  Mamoru Satoh ,  Masaki Takiwaki

IPC: G01N33/82 ,  H01J49/26

Abstract: Provided is a method for quantifying vitamin D, with the vitamin D contained in a biological sample being derivatized with a derivatization reagent and being measured with a mass spectrometer, the method including, a derivatization step of derivatizing n number of samples by using n types of 4-(4′-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues respectively as derivatization reagents, a mixing step of mixing the n types of derivatization samples obtained in the derivatization step, and a quantitative analysis step of subjecting each of the n types of vitamin D derivatives contained in the mixed sample obtained in the mixing step to quantitative analysis using a mass spectrometer.

公开(公告)号：US20180088137A1

公开(公告)日：2018-03-29

申请号：US15718809

申请日：2017-09-28

Applicant: Tokyo University of Science ,  National University Corporation Chiba University ,  JEOL Ltd.

Inventor： Tatsuya Higashi ,  Shoujiro Ogawa ,  Fumio Nomura ,  Mamoru Satoh ,  Masaki Takiwaki

IPC: G01N33/82

Abstract: Provided is a method for derivatizing an s-cis-diene compound with a Cookson-type derivatization reagent, the method including adding, in a reaction stopping step of stopping a derivatization reaction of the s-cis-diene compound, a decomposition inhibitor to inhibit decomposition of a derivative to be obtained.