公开(公告)号：US20200149022A1

公开(公告)日：2020-05-14

申请号：US16628199

申请日：2018-07-06

Applicant: TOOLGEN INCORPORATED

Inventor： Young-Hoon KIM ,  Min Hee JUNG ,  Joonsun LEE ,  Eunji SHIN ,  Kang In LEE ,  Seokjoong KIM ,  Jeongjoon LEE

IPC: C12N9/22 ,  C12N9/78 ,  C12N15/86

Abstract: The present invention relates to an artificially engineered CRISPR/Cas9 system. More particularly, the present invention relates to an artificially engineered CRISPR enzyme having enhanced target specificity and a use of an artificially engineered CRISPR/Cas9 system including the same enzyme in genome and/or epigenome manipulation or modification, genome targeting, genome editing, and in vitro diagnosis, etc.

公开(公告)号：US20230130858A1

公开(公告)日：2023-04-27

申请号：US17880160

申请日：2022-08-03

Applicant: TOOLGEN INCORPORATED

Inventor： Young-Hoon KIM ,  Min Hee JUNG ,  Joonsun LEE ,  Eunji SHIN ,  Kang In LEE ,  Seokjoong KIM ,  Jeongjoon LEE

IPC: C12N9/22 ,  C12N9/78 ,  C12N15/86

Abstract: The present invention relates to an artificially engineered CRISPR/Cas9 system. More particularly, the present invention relates to an artificially engineered CRISPR enzyme having enhanced target specificity and a use of an artificially engineered CRISPR/Cas9 system including the same enzyme in genome and/or epigenome manipulation or modification, genome targeting, genome editing, and in vitro diagnosis, etc.

公开(公告)号：US20250154479A1

公开(公告)日：2025-05-15

申请号：US18832216

申请日：2023-01-20

Applicant: TOOLGEN INCORPORATED

Inventor： Younghoon KIM ,  Keunwoo CHOI ,  Jeongjoon LEE

IPC: C12N9/22 ,  C12N15/11

Abstract: The present disclosure discloses a SpCas9 variant. The SpCas9 variant is characterized by the ability to recognize a PAM sequence different from that of a wild-type SpCas9 protein.