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公开(公告)号：US20250064861A1
公开(公告)日：2025-02-27
申请号：US18944148
申请日：2024-11-12
Applicant: TOOLGEN INCORPORATED
Inventor： Jae Young LEE , Chang Hyun AHN , Kang In LEE , Yu Ri CHOI
IPC: A61K35/39 , A61K35/407 , C12N5/071
Abstract: The present disclosure relates to cells for intravascular transplantation having hemocompatibility in which the blood coagulation mechanism and thrombosis reaction are inhibited by artificially modifying the F3 gene encoding CD142 that is an initiator of blood coagulation, using gene scissors technology to reduce or suppress the expression or activity of CD142, a method of producing the same, and a use thereof for preventing or treating liver disease and diabetes.
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公开(公告)号：US12163149B2
公开(公告)日：2024-12-10
申请号：US18147156
申请日：2022-12-28
Applicant: TOOLGEN INCORPORATED
Inventor： Seokjoong Kim , Dong Woo Song , Jae Young Lee , Jung Min Lee , Gyu-bon Cho , Hee Sook Bae
IPC: C07H21/02 , C12N9/22 , C12N15/113 , C12N15/85
Abstract: The present invention relates to an expression control composition for controlling the expression of a duplicate gene or a method using the same. In addition, the present invention relates to a method of treating or improving a disease caused by gene duplication using the expression control composition for controlling the expression of a duplicate gene.
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公开(公告)号：US20240301424A1
公开(公告)日：2024-09-12
申请号：US18657145
申请日：2024-05-07
Applicant: Toolgen Incorporated
Inventor： Seok Joong Kim , Yoon-Young Kim , Ho-Sung Yu , In-Young Jung , Jung Min Lee
IPC: C12N15/113 , A61K35/14 , C07K14/705 , C12N5/0783 , C12N5/0784 , C12N9/22 , C12N15/10 , C12N15/52 , C12N15/63 , C12N15/85
CPC classification number: C12N15/1132 , A61K35/14 , C07K14/70503 , C07K14/70564 , C07K14/70575 , C07K14/70578 , C07K14/70596 , C12N5/0637 , C12N5/0638 , C12N5/064 , C12N5/0646 , C12N15/102 , C12N15/1138 , C12N15/52 , C12N15/63 , C12N15/85 , C12N9/22 , C12N2310/20 , C12N2320/30 , Y02A50/30
Abstract: The present invention relates to an artificially manipulated immune system having an improved immune effect. More particularly, the present invention relates to an immune system having functions artificially altered which comprises artificially manipulated immunoregulatory elements and cells containing the same. Contemplated according to a particular embodiment is an immune system comprising artificially manipulated immunoregulatory genes such as PD-1, CTLA-4, A20, DGKα, DGKζ, FAS, EGR2, PPP2R2D, PSGL-1, KDM6A, and TET2, and/or expression products thereof
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4.发明公开公开(公告)号：US20240102035A1
公开(公告)日：2024-03-28
申请号：US18522962
申请日：2023-11-29
Applicant: TOOLGEN INCORPORATED
Inventor： Seok Joong KIM , Ok Jae KOO , Min Hee JUNG , Ye Seul KIM
CPC classification number: C12N15/8247 , C12N9/22 , C12N15/11 , C12N2310/20 , C12N2800/80
Abstract: The present invention relates to an artificially manipulated unsaturated fatty acid biosynthesis-associated factor and use thereof to increase the content of a specific unsaturated fatty acid of a plant body. More particularly, the present invention relates to a system capable of artificially controlling unsaturated fatty acid biosynthesis and a plant body produced thereby, which include an artificially manipulated unsaturated fatty acid biosynthesis-associated factor to control unsaturated fatty acid biosynthesis and a composition capable of artificially manipulating the factor. In a specific aspect, the present invention relates to artificially manipulated unsaturated fatty acid biosynthesis-associated factors such as FAD2, FAD3, FAD6, FAD7 and FAD8 and/or an unsaturated fatty acid biosynthesis controlling system by an expression product thereof.
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公开(公告)号：US20230190889A1
公开(公告)日：2023-06-22
申请号：US18157329
申请日：2023-01-20
Applicant: TOOLGEN INCORPORATED
Inventor： DONG WOO SONG , BEOMSEOK CHOI , HYEKYUNG OH , NANYEONG GO , HYERIM LEE , KYU JUN LEE , UN GI KIM , JAEYOUNG LEE , JUNG MIN LEE
CPC classification number: A61K38/465 , A61K31/7105 , A61P7/04 , C12N9/22 , C12N15/11 , C12N15/86 , C12N2310/20 , C12N2750/14143 , C12N2750/14171 , C12N2800/80
Abstract: The present disclosure relates to a composition for gene manipulation for artificially manipulating a blood coagulation inhibitory gene present in the genome of a cell to regulate a blood coagulation system. More particularly, the present invention relates to a composition for gene manipulation, which includes a guide nucleic acid capable of targeting a blood coagulation inhibitory gene, and an editor protein. Also, the present invention relates to a method of treating or improving coagulopathy using the composition for gene manipulation for artificially manipulating a blood coagulation inhibitory gene.
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Patent Agency Ranking
公开(公告)号：US20230063739A1
公开(公告)日：2023-03-02
申请号：US17792203
申请日：2021-01-14
Applicant: TOOLGEN INCORPORATED
Inventor： Eun Ji SHIN , Kang In LEE , Jae Young LEE
IPC: C12N5/0775 , C12N15/11 , C12N9/22 , C12N15/90
Abstract: The present application relates to cells having high adaptability under hypoxic conditions and to a preparation method therefor. Particularly, the present disclosure provides cells having high adaptability under hypoxic conditions, the cells including at least one engineered gene having an indel within a wild-type gene selected from the group consisting of HIF1AN, HIF3A, PHD2, TLR4 and PAI1. In addition, the present disclosure provides, as a method for preparing cells having high adaptability under hypoxic conditions, a gene editing method including introducing a CRISPR/Cas9 system into cells.
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7.发明申请公开(公告)号：US20220228160A1
公开(公告)日：2022-07-21
申请号：US17706921
申请日：2022-03-29
Applicant: TOOLGEN INCORPORATED
Inventor： Seok Joong KIM , Ok Jae KOO , Min Hee JUNG , Ye Seul KIM
Abstract: The present invention relates to an artificially manipulated unsaturated fatty acid biosynthesis-associated factor and use thereof to increase the content of a specific unsaturated fatty acid of a plant body. More particularly, the present invention relates to a system capable of artificially controlling unsaturated fatty acid biosynthesis and a plant body produced thereby, which include an artificially manipulated unsaturated fatty acid biosynthesis-associated factor to control unsaturated fatty acid biosynthesis and a composition capable of artificially manipulating the factor. In a specific aspect, the present invention relates to artificially manipulated unsaturated fatty acid biosynthesis-associated factors such as FAD2, FAD3, FADE, FAD7 and FAD8 and/or an unsaturated fatty acid biosynthesis controlling system by an expression product thereof.
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公开(公告)号：US20220228133A1
公开(公告)日：2022-07-21
申请号：US17613172
申请日：2020-05-22
Applicant: TOOLGEN INCORPORATED
Inventor： Sung Min BAE, , Young Hoon KIM , Jeong Joon LEE
Abstract: The present application relates to: a single base substitution protein; a composition comprising same; and a use thereof.
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公开(公告)号：US20210317448A1
公开(公告)日：2021-10-14
申请号：US17262342
申请日：2019-07-25
Applicant: TOOLGEN INCORPORATED
Inventor： Dong Woo SONG , Jung Min LEE , Kyu Jun LEE , Un Gi KIM
Abstract: The present invention relates to a composition for gene manipulation for artificially manipulating a blood coagulation inhibitory gene present in the genome of a cell to regulate a blood coagulation system. More particularly, the present invention relates to a composition for gene manipulation, which includes a guide nucleic acid capable of targeting a blood coagulation inhibitory gene, and an editor protein. Also, the present invention relates to a method of treating or improving coagulopathy using the composition for gene manipulation for artificially manipulating a blood coagulation inhibitory gene.
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公开(公告)号：US20170145425A1
公开(公告)日：2017-05-25
申请号：US15420936
申请日：2017-01-31
Applicant: TOOLGEN INCORPORATED
Inventor： Eun Ji Kim , Seok Joong Kim
CPC classification number: C12N15/63 , C12N7/00 , C12N9/16 , C12N15/86 , C12N2750/14143
Abstract: The disclosure provided herewith relates to a Campylobacter jejuni CRISPR/CAS system-derived RGEN and a use thereof.
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