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32 条记录 (耗时 0.014 秒)

    CELLS HAVING HIGH ADAPTABILITY UNDER HYPOXIC CONDITIONS, AND USE THEREOF
    6.
    发明申请
    CELLS HAVING HIGH ADAPTABILITY UNDER HYPOXIC CONDITIONS, AND USE THEREOF 有权

    公开(公告)号：US20230063739A1

    公开(公告)日：2023-03-02

    申请号：US17792203

    申请日：2021-01-14

    申请人： TOOLGEN INCORPORATED

    发明人： Eun Ji SHIN ,  Kang In LEE ,  Jae Young LEE

    IPC分类号： C12N5/0775 ,  C12N15/11 ,  C12N9/22 ,  C12N15/90

    摘要： The present application relates to cells having high adaptability under hypoxic conditions and to a preparation method therefor. Particularly, the present disclosure provides cells having high adaptability under hypoxic conditions, the cells including at least one engineered gene having an indel within a wild-type gene selected from the group consisting of HIF1AN, HIF3A, PHD2, TLR4 and PAI1. In addition, the present disclosure provides, as a method for preparing cells having high adaptability under hypoxic conditions, a gene editing method including introducing a CRISPR/Cas9 system into cells.

    OLEIC ACID -ENRICHED PLANT BODY HAVING GENETICALLY MODIFIED FAD2 AND PRODUCTION METHOD THEREOF
    7.
    发明申请
    OLEIC ACID -ENRICHED PLANT BODY HAVING GENETICALLY MODIFIED FAD2 AND PRODUCTION METHOD THEREOF 有权

    公开(公告)号：US20220228160A1

    公开(公告)日：2022-07-21

    申请号：US17706921

    申请日：2022-03-29

    申请人： TOOLGEN INCORPORATED

    发明人： Seok Joong KIM ,  Ok Jae KOO ,  Min Hee JUNG ,  Ye Seul KIM

    IPC分类号： C12N15/82 ,  C12N15/11 ,  C12N9/22

    摘要： The present invention relates to an artificially manipulated unsaturated fatty acid biosynthesis-associated factor and use thereof to increase the content of a specific unsaturated fatty acid of a plant body. More particularly, the present invention relates to a system capable of artificially controlling unsaturated fatty acid biosynthesis and a plant body produced thereby, which include an artificially manipulated unsaturated fatty acid biosynthesis-associated factor to control unsaturated fatty acid biosynthesis and a composition capable of artificially manipulating the factor. In a specific aspect, the present invention relates to artificially manipulated unsaturated fatty acid biosynthesis-associated factors such as FAD2, FAD3, FADE, FAD7 and FAD8 and/or an unsaturated fatty acid biosynthesis controlling system by an expression product thereof.

    GENE EDITING OF ANTICOAGULANTS
    9.
    发明申请
    GENE EDITING OF ANTICOAGULANTS 有权

    公开(公告)号：US20210317448A1

    公开(公告)日：2021-10-14

    申请号：US17262342

    申请日：2019-07-25

    申请人： TOOLGEN INCORPORATED

    发明人： Dong Woo SONG ,  Jung Min LEE ,  Kyu Jun LEE ,  Un Gi KIM

    IPC分类号： C12N15/11 ,  A61P7/04 ,  A61K38/46 ,  A61K31/7088 ,  C12N9/22 ,  A61K9/00 ,  C12N15/86

    摘要： The present invention relates to a composition for gene manipulation for artificially manipulating a blood coagulation inhibitory gene present in the genome of a cell to regulate a blood coagulation system. More particularly, the present invention relates to a composition for gene manipulation, which includes a guide nucleic acid capable of targeting a blood coagulation inhibitory gene, and an editor protein. Also, the present invention relates to a method of treating or improving coagulopathy using the composition for gene manipulation for artificially manipulating a blood coagulation inhibitory gene.