公开(公告)号：US20150125941A1

公开(公告)日：2015-05-07

申请号：US14589492

申请日：2015-01-05

Applicant: TOPPAN PRINTING CO., LTD. ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Takumi HIRASE ,  Masato Nakayama ,  Hiroshi Handa ,  Satoshi Sakamoto ,  Yasuyuki Naito

IPC: G01N33/543 ,  G01N21/64

CPC classification number: G01N33/54326 ,  G01N21/6428 ,  G01N21/645

Abstract: A detection system of a test substance, includes: a magnetic body that is modified by a first substance capable of being bound to the test substance at a first binding site of the test substance; a marker that is modified by a second substance capable of being bound to the test substance at a second binding site of the test substance, the second coupling site being a different site from the first binding site; a development medium that has a flow passage into which liquid, in which the magnetic body and the marker is dispersed, flows due to a capillary phenomenon, the development medium having a detection position for detecting the marker in a portion of the flow passage, the development medium having light transparency at least in the detection position; and a magnetic force generating portion that is equipped in the development medium.

Abstract translation: 测试物质的检测系统包括：被测物质的第一结合位点被能够与被检物质结合的第一物质改性的磁性体; 能够在被检物质的第二结合位点与被检物质结合的第二物质修饰的标记，第二偶联位点是与第一结合位点不同的位点; 具有流路的开发介质，由于毛细管现象，磁性体和标记物分散在其中的液体流动，显影介质具有用于检测流路的一部分中的标记的检测位置， 至少在检测位置具有透光性的显影介质; 以及设置在显影介质中的磁力产生部。

公开(公告)号：US09632077B2

公开(公告)日：2017-04-25

申请号：US14589492

申请日：2015-01-05

Applicant: TOPPAN PRINTING CO., LTD. ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Takumi Hirase ,  Masato Nakayama ,  Hiroshi Handa ,  Satoshi Sakamoto ,  Yasuyuki Naito

IPC: G01N33/543 ,  G01N21/64

CPC classification number: G01N33/54326 ,  G01N21/6428 ,  G01N21/645

Abstract: A detection system of a test substance, includes: a magnetic body that is modified by a first substance capable of being bound to the test substance at a first binding site of the test substance; a marker that is modified by a second substance capable of being bound to the test substance at a second binding site of the test substance, the second coupling site being a different site from the first binding site; a development medium that has a flow passage into which liquid, in which the magnetic body and the marker is dispersed, flows due to a capillary phenomenon, the development medium having a detection position for detecting the marker in a portion of the flow passage, the development medium having light transparency at least in the detection position; and a magnetic force generating portion that is equipped in the development medium.

公开(公告)号：US20140286978A1

公开(公告)日：2014-09-25

申请号：US14117575

申请日：2012-04-24

Applicant: TOKYO INSTITUTE OF TECHNOLOGY ,  LSIP, LLC ,  SAITAMA MEDICAL UNIVERSITY

Inventor： Hiroshi Handa ,  Masaaki Kawano ,  Masanori Matsui

IPC: A61K39/145 ,  A61K39/00

CPC classification number: A61K39/145 ,  A61K35/76 ,  A61K38/162 ,  A61K39/0011 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/55561 ,  C12N2710/22023 ,  C12N2710/22034 ,  C12N2760/16134

Abstract: The invention provides a cytotoxic T lymphocyte inducer comprising a virus-like particle composed of VP1 of simian virus 40. The T cell epitope peptide is inserted into a DE loop and/or an HI loop of the VP1.

Abstract translation: 本发明提供了包含由猿猴病毒40的VP1组成的病毒样颗粒的细胞毒性T淋巴细胞诱导剂.T细胞表位肽插入到VP1的DE环和/或HI环中。