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1.发明申请公开(公告)号：US20200246759A1
公开(公告)日：2020-08-06
申请号：US16853936
申请日：2020-04-21
发明人： Koichi TAKADA , Gohei YAMAMURA , Ryuichiro HIRANABE , Masayuki HANAKAWA , Hiroshi TAKAHASHI , Takaaki MIHARA , Masahiro KIMURA , Hiroki TOMIOKA
摘要： The problem to be solved by the present invention is to provide a separation film mainly comprising a cellulose-based resin having high permeability. The present invention pertains to a separation film containing a cellulose ester, wherein the separation film is provided with a bicontinuous structure comprising voids and phases containing the cellulose ester, and the width of the voids is 1 to 200 nm inclusive.
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公开(公告)号：US20190184371A1
公开(公告)日：2019-06-20
申请号：US16327188
申请日：2017-09-08
发明人： Shungo KANDA , Hiroshi TAKAHASHI , Naotoshi TOMITA
CPC分类号： B01J20/265 , A61M1/36 , B01D15/3828 , B01J20/22 , B01J20/28 , B01J20/28016 , B01J20/28023 , B01J20/28038 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3251 , B01J20/3293 , B01J20/3295
摘要： An object of the present invention is to provide a material for blood purification having the capability to remove cytokines and activated leukocyte-activated platelet complexes. The present invention provides a material for blood purification, the material containing a water-insoluble material in which a ligand having an amide group(s) and an amino group(s) is bound to a substrate, wherein the content of the amide group(s) is 3.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material; and wherein the content of the amino group(s) is 1.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material.
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公开(公告)号：US20220160946A1
公开(公告)日：2022-05-26
申请号：US17442247
申请日：2020-04-21
摘要： The present invention aims to provide a material for adsorbing soluble tumor necrosis factor receptors with high efficiency. The present invention provides an adsorbing material for soluble tumor necrosis factor receptors, which includes a superficially porous water-insoluble polymeric material, wherein the pore size distribution curve for the surface of the water-insoluble polymeric material, which is derived from a distribution of melting points determined by differential scanning calorimeter, shows the peak radius in the range of 1 to 80 nm, and the water-insoluble polymeric material has a zeta potential at pH 7.4 of −15 to 15 mV, and the water-insoluble polymeric material is in fiber, particle, or film form.
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4.发明申请公开(公告)号：US20180162977A1
公开(公告)日：2018-06-14
申请号：US15556002
申请日：2016-03-15
发明人： Suguru USHIRO , Hiroshi TAKAHASHI , Yoshiyuki UENO
IPC分类号： C08F226/10 , C09D139/06 , B01D71/68 , B01D71/76 , A61M1/16 , A61M1/34
CPC分类号： C08F226/10 , A61K35/16 , A61M1/16 , A61M1/34 , A61M2205/7563 , B01D67/0088 , B01D67/009 , B01D69/06 , B01D69/08 , B01D71/38 , B01D71/44 , B01D71/68 , B01D71/76 , C08F218/10 , C08F226/06 , C09D139/06
摘要： A copolymer has blood compatibility and antithrombotic properties of greatly suppressing protein adhesion to be usable even when in contact with a biological component such as blood for a long period of time, and a medical device uses the copolymer. The copolymer is characterized by including a hydrophilic unit and a hydrophobic unit, wherein the hydrophobic unit contains at least one type of a carboxylic acid vinyl unit, and the number of carbon atoms at the terminal of a side chain of the carboxylic acid vinyl unit is 2-7.
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公开(公告)号：US20140256783A1
公开(公告)日：2014-09-11
申请号：US14280408
申请日：2014-05-16
CPC分类号： A61K47/34 , A61K31/40 , A61L31/16 , A61L33/0011 , A61L2300/42 , A61M1/3672 , A61M1/3673
摘要： The present invention relates to a substrate including a compound having blood anticoagulation activity and a hydrophilic polymer compound, wherein the amount of elution of the compound having blood anticoagulation activity is less than 0.6 μg/ml, and a manufacturing method of a substrate, wherein after a compound having blood anticoagulation activity and a hydrophilic compound brought in contact with a substrate are irradiated with radiation, unreacted components are washed out.
摘要翻译： 本发明涉及包含具有血液抗凝活性的化合物和亲水性高分子化合物的底物，其中具有血液抗凝活性的化合物的洗脱量小于0.6μg/ ml，以及基材的制造方法，其中， 将具有血液抗凝活性的化合物和与基质接触的亲水性化合物用辐射照射，将未反应的组分洗掉。
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公开(公告)号：US20210086166A1
公开(公告)日：2021-03-25
申请号：US17113726
申请日：2020-12-07
IPC分类号： B01J20/28 , A61M1/36 , B01D15/38 , B01J20/26 , B01J20/288
摘要： An object of the present invention is to provide a material which can remove an activated leukocyte-activated platelet complex with high efficiency. The present invention provides a material for removing an activated leukocyte-activated platelet complex, the material being a water-insoluble carrier to the surface of which carrier a compound(s) having a charged functional group(s) is(are) bound, wherein an extending length ratio of the surface is 4 to 7.
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7.发明申请公开(公告)号：US20180280893A1
公开(公告)日：2018-10-04
申请号：US15764390
申请日：2016-09-30
发明人： Koichi TAKADA , Gohei YAMAMURA , Ryuichiro HIRANABE , Masayuki HANAKAWA , Hiroshi TAKAHASHI , Takaaki MIHARA , Masahiro KIMURA , Hiroki TOMIOKA
摘要： The problem to be solved by the present invention is to provide a separation film mainly comprising a cellulose-based resin having high permeability. The present invention pertains to a separation film containing a cellulose ester, wherein the separation film is provided with a bicontinuous structure comprising voids and phases containing the cellulose ester, and the width of the voids is 1 to 200 nm inclusive.
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公开(公告)号：US20210213421A1
公开(公告)日：2021-07-15
申请号：US17058951
申请日：2019-07-05
发明人： Shungo KANDA , Kaoru SHIMADA , Shunsuke KOMACHI , Hiroshi TAKAHASHI , Hirofumi YAMANAKA , Masato MASUDA
摘要： An object of the present invention is to provide a carrier for adsorbing organic matter, which achieves both of adsorption ability for organic matter and suppression of pressure increase. The present invention provides a carrier for adsorbing organic matter, comprising a sea-island type solid composite fiber, wherein the pore volume is 0.05 to 0.5 cm3/g and the fiber diameter is 25 to 60 μm.
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