公开(公告)号：US20250049555A1

公开(公告)日：2025-02-13

申请号：US18715262

申请日：2022-12-01

Applicant: TORAY INDUSTRIES, INC. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Koji KADOWAKI ,  Daniel E. GLUMAC ,  Ryan Coulson HUNTER ,  Robroy Henry MACIVER ,  Gregory Kermit PETERSON

IPC: A61F2/04 ,  A61L27/18 ,  A61L27/58

Abstract: A stent for a respiratory organ includes a bioabsorbable polyester copolymer. The bioabsorbable polyester copolymer is a polyester copolymer having residues of two kinds of ester bond forming monomers as main constituent units, and where the two kinds of ester bond forming monomers are referred to as monomer A and monomer B, respectively, an R value given by the following formula is 0.25 or larger and 0.99 or smaller: R=[AB]/(2[A][B]) 100. In the formula, [A] is a mole fraction (%) of monomer A residues in the polyester copolymer; [B] is a mole fraction (%) of monomer B residues in the polyester copolymer; and [AB] is a mole fraction (%) of structures (A-B and B-A) in which a monomer A residue and a monomer B residue are adjacent to each other in the polyester copolymer.

公开(公告)号：US20230323115A1

公开(公告)日：2023-10-12

申请号：US18021701

申请日：2021-10-18

Applicant: TORAY INDUSTRIES, INC.

Inventor： Taisuke KOGAWA ,  Jiao LU ,  Koji KADOWAKI ,  Masataka NAKAMURA

IPC: C08L67/04

CPC classification number: C08L67/04 ,  C08L2205/025 ,  C08L2201/06

Abstract: Disclosed is a polymer composition including a polyester copolymer and a biodegradable polymer, wherein the polyester copolymer includes two types of ester bond-forming monomer residues as main structural units, when the two types of ester bond-forming monomers are defined as “monomer A” and “monomer B”, respectively, the polyester copolymer satisfies (1) to (3) below, the biodegradable polymer has a melting point of 100° C. or higher, and the biodegradable polymer is included in an amount of 0.1% by weight or more and less than 30% by weight in 100% by weight of the total of the polyester copolymer and the biodegradable polymer. The present invention provides a polymer composition having low Young's modulus and high tensile strength. (1) An R value represented by the following formula is 0.45 or more and 0.99 or less. R=[AB]/(2[A][B])×100, where [A]: molar fraction (%) of monomer A residues in the polyester copolymer, [B]: molar fraction (%) of monomer B residues in the polyester copolymer, and [AB]: molar fraction (%) of a structure in which monomer A residues and monomer B residues are adjacent to each other (A-B and B-A) in the polyester copolymer. (2) A crystallization rate of monomer A residues and a crystallization rate of monomer B residues are less than 14%. (3) A melting point is lower than 100° C. or a clear melting point does not exist.

公开(公告)号：US20250127638A1

公开(公告)日：2025-04-24

申请号：US18696138

申请日：2022-09-27

Applicant: TORAY INDUSTRIES, INC. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Koji KADOWAKI ,  Roy Joseph CHO ,  Daniel E. GLUMAC ,  Ryan Coulson HUNTER ,  Gregory Kermit PETERSON

IPC: A61F2/82

Abstract: A stent for a respiratory organ, the stent having an inside surface and an outside surface, includes a base member and a hydrophilic polymer layer. The hydrophilic polymer layer contains a hydrophilic polymer having a hydroxy group and an amide group. The hydrophilic polymer layer is provided on at least a part of the inside surface and/or on at least a part of the outside surface.

公开(公告)号：US20160296679A1

公开(公告)日：2016-10-13

申请号：US15038560

申请日：2014-11-27

Applicant: Toray Industries, Inc.

Inventor： Koji KADOWAKI ,  Masaki FUJITA ,  Yuka SAKAGUCHI ,  Kazuhiro TANAHASHI

IPC: A61L33/00

CPC classification number: A61L33/0041 ,  A61L33/0076

Abstract: An antithrombogenic material includes a coating material containing: a polymer containing, as a constituent monomer, a compound selected from the group consisting of alkyleneimines, vinylamines, allylamines, lysine, protamine and diallyldimethylammonium chloride; and an anionic compound containing a sulfur atom and having anticoagulant activity; and a base material whose surface is coated with the coating material; wherein the polymer is covalently bound to the base material; and an abundance ratio of nitrogen atoms to an abundance of total atoms as measured by X-ray photoelectron spectroscopy (XPS) on a surface of the base material is 6.0 to 12.0 atomic percent.

Abstract translation: 抗血栓形成材料包括涂层材料，其包含：含有作为构成单体的选自由亚烷基亚胺，乙烯胺，烯丙基胺，赖氨酸，鱼精蛋白和二烯丙基二甲基氯化铵组成的组的化合物的聚合物; 和含有硫原子并具有抗凝活性的阴离子化合物; 以及其表面涂覆有所述涂料的基材; 其中所述聚合物共价结合到所述基材上; 并且在基材表面上通过X射线光电子能谱（XPS）测量的氮原子与丰富的总原子的丰度比为6.0〜12.0原子％。