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公开(公告)号：US20240160043A1
公开(公告)日：2024-05-16
申请号：US18278669
申请日：2022-02-04
发明人： Rumiko KITAGAWA , Masataka NAKAMURA
CPC分类号： G02C7/04 , A61L29/085 , A61L2300/404 , A61L2420/02
摘要： An object of the present invention is to provide a simple method for manufacturing a coated medical device allowed to have not only properties such as sufficient hydrophilicity but also a bacteria adhesion inhibiting capability. The present invention provides a method for manufacturing a coated medical device, including: (A) a contacting step of housing a medical device in a container, and bringing the medical device into contact with a solution a containing a hydrophilic polymer A; and (C) a heating step of heating the container; wherein the hydrophilic polymer A is a polymer containing, as a monomer unit, a compound having a quaternary ammonium cation group; and wherein the pH of the solution a after the heating step is 6.1 to 8.0.
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公开(公告)号：US20220008630A1
公开(公告)日：2022-01-13
申请号：US17289117
申请日：2019-09-13
摘要： Disclosed is a medical device including a substrate and a polymer layer, wherein the polymer layer is provided on at least a part of a surface of the substrate and satisfies the following requirements: (a) a water content of the medical device in hydrated state is in a range of 28% by mass or more and 50% by mass or less; (b) the substrate has a 2-alkoxyethyl group; and (c) the polymer layer contains one type of a carboxylic acid group-containing polymer and one type of a copolymer having an amide structure. The present invention provides a medical device capable of maintaining surface wettability for a long time.
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公开(公告)号：US20170204213A1
公开(公告)日：2017-07-20
申请号：US15321516
申请日：2015-06-16
IPC分类号： C08F230/08 , A61L27/52 , G02B1/04 , A61L27/18
CPC分类号： C08F230/08 , A61L27/18 , A61L27/52 , A61L2430/16 , C08F20/26 , G02B1/043 , C08F2230/085 , C08F2220/286 , C08F220/20 , C08F2222/1013
摘要： In order to provide a silicone hydrogel which has high uniformity in polymerization rates of polymerization components used for copolymerization, excellent mechanical characteristics, excellent optical characteristics and good shape recoverability and in order to also provide various medical devices and ocular lenses having an excellent balance among elasticity, wettability and transparency, the present invention provides a silicone hydrogel which has a repeating unit derived from a monofunctional linear silicone (meth)acrylate and a repeating unit derived from a hydrophilic (meth)acrylate, and wherein the content of the repeating units derived from (meth)acrylates is more than 80% by mass.
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公开(公告)号：US20240157027A1
公开(公告)日：2024-05-16
申请号：US18278677
申请日：2022-02-04
发明人： Rumiko KITAGAWA , Masataka NAKAMURA
CPC分类号： A61L27/34 , A61L27/52 , A61L29/085 , A61L29/145 , A61L2400/18 , G02B1/043 , G02C7/04
摘要： An object of the present invention is to provide a coated medical device allowed to have not only properties such as sufficient hydrophilicity but also a bacteria adhesion inhibiting capability, and to provide a simple method of manufacturing the device. The present invention provides a coated medical device and a method of manufacturing the same, the coated medical device including a medical device and a hydrophilic polymer layer coating the surface of the medical device; wherein the hydrophilic polymer layer contains a hydrophilic polymer A, the hydrophilic polymer A containing, as monomer units, a compound a1 having a quaternary ammonium cation group and a compound a2 having a specific structure; and wherein the copolymerization ratio of the compound a1 to the compound a2 is 6/94 to 94/6.
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公开(公告)号：US20220184908A1
公开(公告)日：2022-06-16
申请号：US17442231
申请日：2020-04-16
发明人： Rumiko KITAGAWA , Masataka NAKAMURA
摘要： An objective of the present invention is to provide a method for easily manufacturing a hydrophilized medical device of superior durability. In order to achieve the abovementioned objective, a method for manufacturing a medical device according to the present invention comprises a step for heating an aqueous package fluid, wherein, in the heating step, the aqueous package fluid contains one or more types of hydrophilic polymer, heating is performed with a substrate of the medical device at least partially is contact with the aqueous package fluid, and the following conditions (a) through (c) are all met. (a) The hydrophilic polymer is a (meth)acrylamide (co)polymer comprising two substituents comprising two or more carbon atoms on a nitrogen atom. (b) The mass % concentration of the hydrophilic polymer in the aqueous package fluid is in a range of 0.0001-30 mass %. (c) The pH of the aqueous package fluid after the heating step is in a range of 6.1-8.0.
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公开(公告)号：US20190148756A1
公开(公告)日：2019-05-16
申请号：US16245639
申请日：2019-01-11
IPC分类号： H01M8/1041 , H01M8/1072 , C08G65/40 , C08J5/22 , H01B1/12 , H01M8/1025 , H01M8/1088
摘要： The present invention relates to a method for producing a polymer electrolyte molded article, which comprises forming a polymer electrolyte precursor having a protective group and an ionic group, and deprotecting at least a portion of protective groups contained in the resulting molded article to obtain a polymer electrolyte molded article. According to the present invention, it is possible to obtain a polymer electrolyte material and a polymer electrolyte molded article, which are excellent in proton conductivity and are also excellent in fuel barrier properties, mechanical strength, physical durability, resistance to hot water, resistance to hot methanol, processability and chemical stability. A polymer electrolyte fuel cell using a polymer electrolyte membrane, polymer electrolyte parts or a membrane electrode assembly can achieve high output, high energy density and long-term durability.
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公开(公告)号：US20220008631A1
公开(公告)日：2022-01-13
申请号：US17289588
申请日：2019-12-05
发明人： Rumiko KITAGAWA , Masataka NAKAMURA
IPC分类号： A61L31/14 , A61L15/24 , A61L15/44 , A61L27/18 , A61L27/34 , A61L27/52 , A61L27/54 , A61L29/06 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/16 , C08G77/20
摘要： A medical device including a substrate and a hydrophilic polymer layer and satisfying the following conditions: (1) that the hydrophilic polymer layer is on at least a part of the substrate; (2) that the hydrophilic polymer layer contains: a hydrophilic polymer having an acidic group; and a compound having an acidic group and a ring structure; and (3) that a time during which a liquid film is retained on the surface of the medical device (a liquid film retention time) is 10 seconds or more after the medical device is stationarily immersed in a phosphate buffer solution, pulled up from the phosphate buffer solution, and retained in the air. The present invention provides a medical device in which a surface of a substrate is hydrophilized, and a method for manufacturing same by a simple method.
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公开(公告)号：US20210395526A1
公开(公告)日：2021-12-23
申请号：US17289560
申请日：2019-12-05
发明人： Rumiko KITAGAWA , Masataka NAKAMURA
摘要： A medical device including an internal wetting agent and a copolymer of a silicone monomer and satisfying the following conditions: (1) that the internal wetting agent contains a copolymer of an open-chain compound having an acidic group and an open-chain compound having an amide group; (2) that the internal wetting agent is contained in the range of from 0.1 to 10% by mass with respect to the whole medical device; and (3) that the copolymer of a silicone monomer has a hydroxyl group and that the content ratio of the hydroxyl group in the silicone monomer is in the range of from 0.0005 to 0.01 equivalents/g. A medical device containing an internal wetting agent and having excellent transparency and hydrophilicity can be obtained.
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公开(公告)号：US20160331261A1
公开(公告)日：2016-11-17
申请号：US15111647
申请日：2015-02-05
IPC分类号： A61B5/0478 , A61B5/04
CPC分类号： A61B5/0478 , A61B5/04001 , C08G77/20 , C09D183/06 , C08L83/00
摘要： In order to provide an electrode equipped with an insulating wall having excellent patterning properties as well as excellent biocompatibility, there is provided an electrode including, on a substrate, an electrode element; and an insulating wall formed around the electrode element, constituted of a polysiloxane compound (component A) having, per molecule, two or more functional groups selected from the group consisting of a (meth)acryloyl group, a styrenic vinyl group, a vinyl ester group, a maleic acid ester group and a maleimide group, and formed from a polymer obtained by reaction of the functional groups.
摘要翻译： 为了提供具有优异的图案化特性以及优异的生物相容性的绝缘壁的电极，提供了一种在基板上包括电极元件的电极; 以及由分子中具有选自（甲基）丙烯酰基，苯乙烯基，乙烯基酯中的两种以上官能团的聚硅氧烷化合物（A成分）构成的电极元件周围形成的绝缘壁 基团，马来酸酯基和马来酰亚胺基，并且由通过官能团反应获得的聚合物形成。
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公开(公告)号：US20240139382A1
公开(公告)日：2024-05-02
申请号：US18278738
申请日：2022-02-04
发明人： Rumiko KITAGAWA , Masataka NAKAMURA
CPC分类号： A61L29/085 , A61L26/008 , A61L29/145 , A61L31/10 , A61L31/145 , A61L2300/424 , A61L2400/10 , A61L2420/02
摘要： An object of the present invention is to provide a coated medical device allowed to have not only sufficient hydrophilicity and lubricity but also a lipid adhesion inhibiting capability, and to provide a simple method for manufacturing the device. The present invention provides a coated medical device and a method for manufacturing the same, the coated medical device including a medical device and a hydrophilic polymer layer coating the surface of the medical device; wherein the hydrophilic polymer layer contains a hydrophilic polymer A, the hydrophilic polymer A containing, as monomer units, a compound a1 having a specific structure and a compound a2 having an amide group; and wherein the copolymerization ratio of the compound a1 to the compound a2 is 1/99 to 99/1 by mass.
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