公开(公告)号：US20240132943A1

公开(公告)日：2024-04-25

申请号：US18279614

申请日：2022-03-16

Applicant: Toray Industries, Inc.

Inventor： Yoichiro KOSHI ,  Osamu WAKAO

IPC: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6886

CPC classification number: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6886

Abstract: The microRNA detection level decreases when a microRNA-containing biological sample is preserved after being collected. Further, a relatively long period of time is required for dissolving a hydrochloride of a neutral amino acid, which is in the form of crystals, in water. Since a hydrochloride of a neutral amino acid is an acidic substance, and causes skin irritation and mucosal irritation, the handling of the hydrochloride requires safety precautions. The present invention provides a method of detecting a microRNA in a biological sample, the method including the steps of: mixing an acid with the biological sample, preserving the resulting mixture for a predetermined period of time, collecting the microRNA in the biological sample, and detecting the microRNA. Further, the present invention provides a homogeneous semi-solid composition composed of a hydrochloride of a neutral amino acid, water and an alcohol.

公开(公告)号：US20240417804A1

公开(公告)日：2024-12-19

申请号：US18703017

申请日：2022-10-20

Applicant: TORAY INDUSTRIES, INC.

Inventor： Osamu WAKAO ,  Chie IWASAKI ,  Hiroko SUDO

IPC: C12Q1/6886

Abstract: Provided are a kit or device for detecting ovarian cancer, and an ovarian cancer detection method. The kit or device for detecting ovarian cancer comprises a nucleic acid capable of bonding specifically with miRNA in a sample derived from a subject, and the ovarian cancer detection method comprises measuring the miRNA in vitro.

公开(公告)号：US20240229116A9

公开(公告)日：2024-07-11

申请号：US18279614

申请日：2022-03-17

Applicant: Toray Industries, Inc.

Inventor： Yoichiro KOSHI ,  Osamu WAKAO

IPC: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6886

CPC classification number: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6886

Abstract: The microRNA detection level decreases when a microRNA-containing biological sample is preserved after being collected. Further, a relatively long period of time is required for dissolving a hydrochloride of a neutral amino acid, which is in the form of crystals, in water. Since a hydrochloride of a neutral amino acid is an acidic substance, and causes skin irritation and mucosal irritation, the handling of the hydrochloride requires safety precautions. The present invention provides a method of detecting a microRNA in a biological sample, the method including the steps of: mixing an acid with the biological sample, preserving the resulting mixture for a predetermined period of time, collecting the microRNA in the biological sample, and detecting the microRNA. Further, the present invention provides a homogeneous semi-solid composition composed of a hydrochloride of a neutral amino acid, water and an alcohol.