公开(公告)号：US20240229116A9

公开(公告)日：2024-07-11

申请号：US18279614

申请日：2022-03-17

Applicant: Toray Industries, Inc.

Inventor： Yoichiro KOSHI ,  Osamu WAKAO

IPC: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6886

CPC classification number: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6886

Abstract: The microRNA detection level decreases when a microRNA-containing biological sample is preserved after being collected. Further, a relatively long period of time is required for dissolving a hydrochloride of a neutral amino acid, which is in the form of crystals, in water. Since a hydrochloride of a neutral amino acid is an acidic substance, and causes skin irritation and mucosal irritation, the handling of the hydrochloride requires safety precautions. The present invention provides a method of detecting a microRNA in a biological sample, the method including the steps of: mixing an acid with the biological sample, preserving the resulting mixture for a predetermined period of time, collecting the microRNA in the biological sample, and detecting the microRNA. Further, the present invention provides a homogeneous semi-solid composition composed of a hydrochloride of a neutral amino acid, water and an alcohol.

公开(公告)号：US20240132943A1

公开(公告)日：2024-04-25

申请号：US18279614

申请日：2022-03-16

Applicant: Toray Industries, Inc.

Inventor： Yoichiro KOSHI ,  Osamu WAKAO

IPC: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6886

CPC classification number: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6886

Abstract: The microRNA detection level decreases when a microRNA-containing biological sample is preserved after being collected. Further, a relatively long period of time is required for dissolving a hydrochloride of a neutral amino acid, which is in the form of crystals, in water. Since a hydrochloride of a neutral amino acid is an acidic substance, and causes skin irritation and mucosal irritation, the handling of the hydrochloride requires safety precautions. The present invention provides a method of detecting a microRNA in a biological sample, the method including the steps of: mixing an acid with the biological sample, preserving the resulting mixture for a predetermined period of time, collecting the microRNA in the biological sample, and detecting the microRNA. Further, the present invention provides a homogeneous semi-solid composition composed of a hydrochloride of a neutral amino acid, water and an alcohol.

公开(公告)号：US20160256543A1

公开(公告)日：2016-09-08

申请号：US15028266

申请日：2014-10-09

Applicant: TORAY INDUSTRIES, INC.

Inventor： Yoichiro KOSHI ,  Joonsik PARK ,  Jiao LU

IPC: A61K39/39 ,  A61K47/48 ,  A61K9/16 ,  A61K39/00

Abstract: There is provided an immunopotentiator comprising, as an active ingredient, a modified β-glucan which β-glucan and poly(hydroxy acid) are covalently bonded. The immunopotentiator can potently enhance the immunopotentiating effect of β-glucan.

Abstract translation: 提供了一种免疫增强剂，其包含β-葡聚糖和聚（羟基酸）共价结合的改性β-葡聚糖作为活性成分。 免疫增强剂可以有效增强β-葡聚糖的免疫增强作用。