公开(公告)号：US10765637B2

公开(公告)日：2020-09-08

申请号：US16087557

申请日：2017-03-23

Applicant: TOYO UNIVERSITY

Inventor： Toru Maekawa ,  Sakthikumar Dasappan Nair ,  Sheikh Mohamed Mohamed ,  Srivani Veeranarayanan

IPC: A61K9/51 ,  A61K47/10 ,  A61K47/12 ,  A61K47/24 ,  A61K47/42 ,  A61K49/00 ,  A61K9/16 ,  A61K45/00 ,  A61P35/00 ,  A61K38/16 ,  B82Y5/00

Abstract: Provided is a composition which can be utilized for drug delivery systems that can penetrate the blood brain barrier, and has low cytotoxicity. A nanoparticle composition comprises nanoparticles to the surface of which a first substance and a second substance each having specificity to a tumor cell are bound, wherein the first substance having specificity to the tumor cell is a peptide comprising an amino acid sequence of arginine-glycine-aspartic acid, and wherein the second substance having specificity to the tumor cell is an iron-binding protein, and wherein the nanoparticles each comprise an outer layer and vesicles enveloped by the outer layer and the nanoparticles each comprise, as membrane components, a PEGylated phospholipid, a fatty acid with a melting point of 30° C. or more, and a non-PEGylated phospholipid.