公开(公告)号：US20240342269A1

公开(公告)日：2024-10-17

申请号：US17923497

申请日：2021-05-07

申请人： TRANSLATE BIO, INC.

发明人： Anusha DIAS ,  Khang Anh TRAN ,  Minnie ZACHARIA ,  Xiaobo GU ,  Lianne BOEGLIN ,  Joseph A. SKALESKI ,  Shrirang KARVE ,  Frank DEROSA ,  Tong-Ming FU ,  Kirill KALNIN ,  Sudha CHIVUKULA ,  Timothy PLITNIK ,  Danilo CASIMIRO ,  Jeffrey S. DUBINS

IPC分类号： A61K39/215 ,  A61K9/51 ,  A61K39/00 ,  A61P31/14 ,  C07K14/005

CPC分类号： A61K39/215 ,  A61K9/5123 ,  A61P31/14 ,  C07K14/005 ,  A61K2039/53 ,  C12N2770/20022 ,  C12N2770/20034

摘要： The present invention relates to optimized nucleotide sequence encoding SARS-COV-2 antigens. These sequences are particularly suitable for use in vaccine compositions for the treatment or prevention of infections caused by a β-coronaviruses, including COVID-19 infections, in a human or animal subject in need of such treatment.