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公开(公告)号：US09796641B2
公开(公告)日：2017-10-24
申请号：US14861192
申请日：2015-09-22
申请人： Trasis S.A.
IPC分类号： C07C229/00 , C07B63/04 , A61K51/04 , C07C227/12 , C07C227/18
CPC分类号： C07B63/04 , A61K51/0402 , C07B2200/05 , C07C227/12 , C07C227/18
摘要： The present invention relates to a method for stabilizing radiosynthetic intermediates used in synthesis of 18F radiolabeled aromatic amino acid derivatives toward decomposition caused by beta and gamma radiations by the use of radical scavengers and/or reductants and/or antioxidants.
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公开(公告)号：US09839702B2
公开(公告)日：2017-12-12
申请号：US14895842
申请日：2014-06-02
申请人： Trasis S.A.
IPC分类号： C07C213/10 , A61K51/04 , C07B59/00
CPC分类号： A61K51/0406 , A61K51/04 , C07B59/00 , C07B59/001 , C07C213/10
摘要： The present invention relates to a method for purification of 18F-labeled choline analogs in a solution injectable to a patient, prepared using non-gaseous synthesis paths, comprising a step of solid phase extraction (SPE) purification using a solid support, wherein the solid support used in the solid phase extraction purification has the characteristic to retain impurities and reagents from the solution but not the 18F-labeled choline analogs.
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公开(公告)号：US20160129139A1
公开(公告)日：2016-05-12
申请号：US14895842
申请日：2014-06-02
申请人： TRASIS S.A.
IPC分类号： A61K51/04 , C07C213/10 , C07B59/00
CPC分类号： A61K51/0406 , A61K51/04 , C07B59/00 , C07B59/001 , C07C213/10
摘要： The present invention relates to a method for purification of 18F-labeled choline analogues in a solution injectable to a patient, prepared using non-gaseous synthesis paths, comprising a step of solid phase extraction (SPE) purification using a solid support, wherein the solid support used in the solid phase extraction purification has the characteristic to retain impurities and reagents from the solution but not the 18F-labeled choline analogues.
摘要翻译： 本发明涉及一种使用非气体合成路径制备的向患者注射的溶液中18F标记的胆碱类似物的纯化方法，该方法包括使用固体支持物进行固相萃取（SPE）纯化步骤，其中固体 用于固相萃取纯化的载体具有从溶液中保留杂质和试剂而不是18F标记的胆碱类似物的特征。
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公开(公告)号：US20160075615A1
公开(公告)日：2016-03-17
申请号：US14861192
申请日：2015-09-22
申请人： Trasis S.A.
IPC分类号： C07B63/04 , C07C227/12 , A61K51/04 , C07C227/18
CPC分类号： C07B63/04 , A61K51/0402 , C07B2200/05 , C07C227/12 , C07C227/18
摘要： The present invention relates to a method for stabilizing radiosynthetic intermediates used in synthesis of 18F radiolabeled aromatic amino acid derivatives toward decomposition caused by beta and gamma radiations by the use of radical scavengers and/or reductants and/or antioxidants.
摘要翻译： 本发明涉及一种稳定放射合成中间体的方法，该方法用于通过使用自由基清除剂和/或还原剂和/或抗氧化剂合成18F放射性标记的芳香族氨基酸衍生物，分解成由β和γ辐射引起的分解。
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