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公开(公告)号:US11275060B2
公开(公告)日:2022-03-15
申请号:US16638476
申请日:2018-08-13
申请人: TRASIS S.A.
摘要: A device for preparing a liquid sample for a direct injection of a corresponding gaseous sample to a micro-gas chromatograph includes: a fluid space and a gas space, which spaces are separated by a semipermeable separating layer, the fluid space including a supply line for the liquid sample, and the gas space having an outlet connectable with the gas chromatograph. The fluid space and/or the gas space is associated with at least one heating element. The device absorbs a sample volume of approximately 10 μl to 30 μl. The separating layer has a thickness of 10 μl to 300 μl and pores having a size between 0.05 μl and 5 μl.
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公开(公告)号:US20240076248A1
公开(公告)日:2024-03-07
申请号:US18261493
申请日:2022-01-24
申请人: Trasis S.A.
发明人: Thomas VERGOTE , Julien MASSET , Corentin WARNIER , Jean-Luc MORELLE , Charles VRIAMONT , Frederique BLANC-BEGUIN , Pierre-Yves LEROUX , Peter EU
CPC分类号: C07B59/008 , A61K51/081 , A61K51/1255 , C07K1/34 , C07B2200/05
摘要: A method for synthesis and purification of radiolabeled macroaggregated human serum albumin (MAA) to form a bulk solution injectable to a patient includes: providing a radiometal in a generator, the radiometal being a generator eluate; synthesizing the radiolabeled MAA in a reactor with MAA particles from a commercially available labeling kit for 99mTc and the generator eluate so as to provide synthesized radiolabeled MAA particles; passing the synthesized radiolabeled MAA particles on a syringe filter membrane having a membrane composition, diameter, and pore size for trapping the radiolabeled MAA particles as trapped radiolabeled MAA particles and not retaining impurities from a bulk solution, the impurities including free radioactive metal isotopes, parent radioactive metal breakthrough, and stannous chloride present in the MAA labeling kit for 99mTc; and untrapping the trapped radiolabeled MAA particles from the syringe filter using a saline or buffered solution passing through the syringe filter.
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公开(公告)号:US10788142B2
公开(公告)日:2020-09-29
申请号:US16093144
申请日:2017-03-09
申请人: Trasis S.A.
摘要: A stopcock manifold system includes: a manifold provided with one or several stopcocks, each having a rotary opening/closing control apparatus with at least one finger or crank pin; a rotary mechanized actuator coupling part for each manifold, a rotary axis of the coupling part corresponding in use to a rotation axis of the control apparatus, the coupling part coupling with the stopcock by insertion of each crank pin into a closed notch in the coupling part, the closed notch of each coupling part receiving one of the crank pins of the corresponding stopcock, such that the crank pin is insertable into the corresponding coupling part by tilting the manifold and then straightening it, until it abuts on a first bearing point comprised of an edge of the closed notch; and a maintaining system that enables each coupling part to individually maintain the corresponding stopcock in place.
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公开(公告)号:US09796641B2
公开(公告)日:2017-10-24
申请号:US14861192
申请日:2015-09-22
申请人: Trasis S.A.
IPC分类号: C07C229/00 , C07B63/04 , A61K51/04 , C07C227/12 , C07C227/18
CPC分类号: C07B63/04 , A61K51/0402 , C07B2200/05 , C07C227/12 , C07C227/18
摘要: The present invention relates to a method for stabilizing radiosynthetic intermediates used in synthesis of 18F radiolabeled aromatic amino acid derivatives toward decomposition caused by beta and gamma radiations by the use of radical scavengers and/or reductants and/or antioxidants.
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公开(公告)号:US20130109907A1
公开(公告)日:2013-05-02
申请号:US13707849
申请日:2012-12-07
申请人: TRASIS S.A.
IPC分类号: A61N5/10
CPC分类号: A61N5/1007 , A61M5/1785 , A61M5/2466 , A61M5/31515 , A61M5/346 , G21F5/015
摘要: A cartridge for radiopharmaceutical packaging includes a low UV-absorbing plastic barrel, closed at one end by a cap and at the other by a piston. A shoulder cooperates with the barrel in a double-level snap-on system with a cavity cooperating with an injection fitting sleeve to make a seal. At a first end the cap has a peel-off porous liner covering the cavity. Radial fins protrude inside the cavity, for screwing the injection fitting and second radial fins protrude outside of the cap to fix to a cartridge protection shield. A second end minimizes a shadow area of UV flash lamp sterilization and ensures clearance for inserting an injection spike. The second end has a reduced wall thickness pierced by the spike during set up for dispensing of the pharmaceutical. An external cylindrical zone at the second end ensures leak tightness between the cap and the barrel.
摘要翻译: 用于放射性药物包装的药筒包括低吸收UV的塑料桶,其一端由帽封闭,另一端由活塞封闭。 一个肩部与一个双层卡扣系统配合,其中一个空腔与一个注射套管配合以形成一个密封。 在第一端,盖具有覆盖空腔的剥离多孔衬里。 径向翼片突出在空腔内部,用于拧入注射配件,第二径向翅片突出到盖的外侧,以固定到药筒保护罩。 第二端可最大限度地减少UV闪光灯灭菌的阴影区域,并确保插入注射尖峰的间隙。 第二端在用于分配药物的设置期间具有由尖峰刺穿的壁厚减小。 在第二端的外部圆柱形区域确保了盖和桶之间的密封性。
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公开(公告)号:US20190338864A1
公开(公告)日:2019-11-07
申请号:US16093144
申请日:2017-03-09
申请人: Trasis S.A.
摘要: A stopcock manifold system includes: a manifold provided with one or several stopcocks, each having a rotary opening/closing control apparatus with at least one finger or crank pin; a rotary mechanized actuator coupling part for each manifold, a rotary axis of the coupling part corresponding in use to a rotation axis of the control apparatus, the coupling part coupling with the stopcock by insertion of each crank pin into a closed notch in the coupling part, the closed notch of each coupling part receiving one of the crank pins of the corresponding stopcock, such that the crank pin is insertable into the corresponding coupling part by tilting the manifold and then straightening it, until it abuts on a first bearing point comprised of an edge of the closed notch; and a maintaining system that enables each coupling part to individually maintain the corresponding stopcock in place.
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公开(公告)号:US09839702B2
公开(公告)日:2017-12-12
申请号:US14895842
申请日:2014-06-02
申请人: Trasis S.A.
IPC分类号: C07C213/10 , A61K51/04 , C07B59/00
CPC分类号: A61K51/0406 , A61K51/04 , C07B59/00 , C07B59/001 , C07C213/10
摘要: The present invention relates to a method for purification of 18F-labeled choline analogs in a solution injectable to a patient, prepared using non-gaseous synthesis paths, comprising a step of solid phase extraction (SPE) purification using a solid support, wherein the solid support used in the solid phase extraction purification has the characteristic to retain impurities and reagents from the solution but not the 18F-labeled choline analogs.
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公开(公告)号:US20160129139A1
公开(公告)日:2016-05-12
申请号:US14895842
申请日:2014-06-02
申请人: TRASIS S.A.
IPC分类号: A61K51/04 , C07C213/10 , C07B59/00
CPC分类号: A61K51/0406 , A61K51/04 , C07B59/00 , C07B59/001 , C07C213/10
摘要: The present invention relates to a method for purification of 18F-labeled choline analogues in a solution injectable to a patient, prepared using non-gaseous synthesis paths, comprising a step of solid phase extraction (SPE) purification using a solid support, wherein the solid support used in the solid phase extraction purification has the characteristic to retain impurities and reagents from the solution but not the 18F-labeled choline analogues.
摘要翻译: 本发明涉及一种使用非气体合成路径制备的向患者注射的溶液中18F标记的胆碱类似物的纯化方法,该方法包括使用固体支持物进行固相萃取(SPE)纯化步骤,其中固体 用于固相萃取纯化的载体具有从溶液中保留杂质和试剂而不是18F标记的胆碱类似物的特征。
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公开(公告)号:US20160075615A1
公开(公告)日:2016-03-17
申请号:US14861192
申请日:2015-09-22
申请人: Trasis S.A.
IPC分类号: C07B63/04 , C07C227/12 , A61K51/04 , C07C227/18
CPC分类号: C07B63/04 , A61K51/0402 , C07B2200/05 , C07C227/12 , C07C227/18
摘要: The present invention relates to a method for stabilizing radiosynthetic intermediates used in synthesis of 18F radiolabeled aromatic amino acid derivatives toward decomposition caused by beta and gamma radiations by the use of radical scavengers and/or reductants and/or antioxidants.
摘要翻译: 本发明涉及一种稳定放射合成中间体的方法,该方法用于通过使用自由基清除剂和/或还原剂和/或抗氧化剂合成18F放射性标记的芳香族氨基酸衍生物,分解成由β和γ辐射引起的分解。
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