公开(公告)号：US20210335515A1

公开(公告)日：2021-10-28

申请号：US17345719

申请日：2021-06-11

Applicant: TRIUMF INC.

Inventor： Paul SCHAFFER ,  Francois BENARD ,  Kenneth R. BUCKLEY ,  Victoire HANEMAAYER ,  Cornelia Hoehr MANUELA ,  Julius Alexander KLUG ,  Michael S. KOVACS ,  Thomas J. MORLEY ,  Thomas J. RUTH ,  John VALLIANT ,  Stefan K. ZEISLER ,  Maurice G. DODD

IPC: G21G1/00 ,  G21F5/14 ,  B22F1/00 ,  C25D13/02 ,  C25D13/22 ,  H05H6/00 ,  G21G1/10 ,  B22F7/02

Abstract: A system for producing technetium-99m from molybdate-100. The system comprises: a target capsule apparatus for housing a Mo-100-coated target plate; a target capsule pickup apparatus for engaging, and delivering. the target cell apparatus into a target station apparatus target station apparatus for receiving and mounting therein the target capsule apparatus. The target station apparatus is engaged with a cyclotron for irradiating the Mo-100-coated target plate with protons. The irradiated target capsule apparatus is transferred to a receiving cell apparatus comprising a dissolution/purification module for receiving therein a proton-irradiated Mo-100-coated target plate. A conveyance conduit infrastructure interconnects: (i) the target capsule pickup apparatus with the target station apparatus, (ii) the target station apparatus and the receiving cell apparatus, and (iii) the receiving cell apparatus and the dissolution/purification module.

公开(公告)号：US20240011179A1

公开(公告)日：2024-01-11

申请号：US18137877

申请日：2023-04-21

Applicant: TRIUMF INC.

Inventor： Paul SCHAFFER ,  Francois BENARD ,  Kenneth R. BUCKLEY ,  Victoire HANEMAAYER ,  Cornelia Manuela HOEHR ,  Julius Alexander KLUG ,  Michael S. KOVACS ,  Thomas J. MORLEY ,  Thomas J. RUTH ,  John VALLIANT ,  Stefan K. ZEISLER ,  Maurice G. DODD

IPC: C25D13/22 ,  G21G1/00 ,  C25D13/02 ,  G21F5/14 ,  G21K5/08 ,  B22F1/145

CPC classification number: C25D13/22 ,  G21G1/001 ,  C25D13/02 ,  H05H6/00 ,  G21K5/08 ,  B22F1/145 ,  G21F5/14

Abstract: A system for producing technetium-99m from molybdate-100. The system comprises: a target capsule apparatus for housing a Mo-100-coated target plate; a target capsule pickup apparatus for engaging and delivering the target cell apparatus into a target station apparatus; a target station apparatus for receiving and mounting therein the target capsule apparatus. The target station apparatus is engaged with a cyclotron for irradiating the Mo-100-coated target plate with protons. The irradiated target capsule apparatus is transferred to a receiving cell apparatus comprising a dissolution/purification module for receiving therein a proton-irradiated Mo-100-coated target plate. A conveyance conduit infrastructure interconnects: (i) the target capsule pickup apparatus with the target station apparatus, (ii) the target station apparatus and the receiving cell apparatus; and (iii) the receiving cell apparatus and the dissolution/purification module.

公开(公告)号：US20230270892A1

公开(公告)日：2023-08-31

申请号：US17801777

申请日：2021-02-25

Applicant: TRIUMF INC. ,  Provincial Health Services Authority ,  The University of British Columbia

Inventor： Hua YANG ,  Feng GAO ,  Paul SCHAFFER ,  Zheliang YUAN ,  Chengcheng ZHANG ,  Francois BENARD ,  Luke WHARTON

IPC: A61K51/04 ,  C07D273/00 ,  A61K51/08

CPC classification number: A61K51/044 ,  A61K51/088 ,  C07D273/00

Abstract: A chelator having the general structure (I) for chelating ra-diometals such as 225Ac under mild conditions is provided. (I) The chelator can be coupled to a biological targeting moiety to facilitate targeted delivery of the chelated radiometal in a mammalian subject.