公开(公告)号：US10377716B2

公开(公告)日：2019-08-13

申请号：US15785193

申请日：2017-10-16

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： F. Jon Kull ,  Ronald K. Taylor ,  Gordon W. Gribble ,  Evans O. Onyango ,  Anne R. Kelley

IPC: C07D217/12 ,  C07D209/12 ,  C07D215/14 ,  A23L33/10

Abstract: Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.

公开(公告)号：US09796679B2

公开(公告)日：2017-10-24

申请号：US15117940

申请日：2015-02-09

Applicant: Trustees of Dartmouth College

Inventor： Ronald K. Taylor ,  Gordon W. Gribble

IPC: C07D215/00 ,  C07D215/42

CPC classification number: C07D215/42

Abstract: Compounds for inhibiting Type 4 Prepilin Peptidases are provided as are methods of using the compounds as anti-bacterial agents.

公开(公告)号：US20180029990A1

公开(公告)日：2018-02-01

申请号：US15785193

申请日：2017-10-16

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： F. Jon Kull ,  Ronald K. Taylor ,  Gordon W. Gribble ,  Evans O. Onyango ,  Anne R. Kelley

IPC: C07D217/12 ,  C07D209/12 ,  A23L33/10 ,  C07D215/14

CPC classification number: C07D217/12 ,  A23L33/10 ,  C07D209/12 ,  C07D215/14

Abstract: Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.

公开(公告)号：US09790186B2

公开(公告)日：2017-10-17

申请号：US14837139

申请日：2015-08-27

Applicant: Trustees of Dartmouth College

Inventor： F. Jon Kull ,  Ronald K. Taylor ,  Gordon W. Gribble ,  Evans O. Onyango ,  Anne R. Kelley

IPC: C07D217/12 ,  C07D209/12 ,  C07D215/14 ,  A23L33/10

CPC classification number: C07D217/12 ,  A23L33/10 ,  C07D209/12 ,  C07D215/14

Abstract: Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.

公开(公告)号：US20160355481A1

公开(公告)日：2016-12-08

申请号：US15117940

申请日：2015-02-09

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Ronald K. Taylor ,  Gordon W. Gribble

IPC: C07D215/42

CPC classification number: C07D215/42

Abstract: Compounds for inhibiting Type 4 Prepilin Peptidases are provided as are methods of using the compounds as an ti-bacterial agents.

Abstract translation: 还提供了用于抑制4型Prepilin肽酶的化合物，其方法是使用化合物作为ti细菌剂。

公开(公告)号：US20150361045A1

公开(公告)日：2015-12-17

申请号：US14837139

申请日：2015-08-27

Applicant: Trustees of Dartmouth College

Inventor： F. Jon Kull ,  Ronald K. Taylor ,  Gordon W. Gribble ,  Evans O. Onyango ,  Anne R. Kelley

IPC: C07D217/12 ,  A23L1/30 ,  C07D209/12 ,  C07D215/14 ,  C07C59/84 ,  C07C57/40

CPC classification number: C07D217/12 ,  A23L33/10 ,  C07D209/12 ,  C07D215/14

Abstract: Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.

Abstract translation: 提供了用于降低细菌毒力因子的表达从而预防，缓解或治疗细菌感染的双环化合物。