公开(公告)号：US20200150457A1

公开(公告)日：2020-05-14

申请号：US16561776

申请日：2019-09-05

Applicant: TSUBOTA LABORATORY, INC.

Inventor： Shinichi IKEDA ,  Xiaoyan JIANG ,  Kazuo TSUBOTA ,  Toshihide KURIHARA

IPC: G02C7/06 ,  A01K67/02 ,  A61K31/575 ,  A61K9/00

Abstract: A model that closely resembles human excessive myopia can be prepared by mounting a minus lens (2) and a protector (4) to a juvenile mouse, the minus lens having an angle and a width adjustable in response to growth of the mouse. Further, this model analysis shows that myopia induction causes endoplasmic reticulum stress in a sclera and the endoplasmic reticulum stress induces myopia. Furthermore, it is revealed that an endoplasmic reticulum stress suppressant, particularly, phenylbutyrate and tauroursodeoxycholic acid act as a myopia prevention/suppression agent.

公开(公告)号：US20240210736A1

公开(公告)日：2024-06-27

申请号：US18600985

申请日：2024-03-11

Applicant: TSUBOTA LABORATORY, INC.

Inventor： Shinichi IKEDA ,  Xiaoyan JIANG ,  Kazuo TSUBOTA ,  Toshihide KURIHARA

IPC: G02C7/06 ,  A01K67/02 ,  A61K9/00 ,  A61K31/575

CPC classification number: G02C7/06 ,  A01K67/02 ,  A61K9/0048 ,  A61K31/575 ,  A01K2227/105 ,  A01K2267/03

Abstract: A model that closely resembles human excessive myopia can be prepared by mounting a minus lens (2) and a protector (4) to a juvenile mouse, the minus lens having an angle and a width adjustable in response to growth of the mouse. Further, this model analysis shows that myopia induction causes endoplasmic reticulum stress in a sclera and the endoplasmic reticulum stress induces myopia. Furthermore, it is revealed that an endoplasmic reticulum stress suppressant, particularly, phenylbutyrate and tauroursodeoxycholic acid act as a myopia prevention/suppression agent.