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1.发明申请公开(公告)号：US20200150457A1
公开(公告)日：2020-05-14
申请号：US16561776
申请日：2019-09-05
IPC分类号： G02C7/06 , A01K67/02 , A61K31/575 , A61K9/00
摘要： A model that closely resembles human excessive myopia can be prepared by mounting a minus lens (2) and a protector (4) to a juvenile mouse, the minus lens having an angle and a width adjustable in response to growth of the mouse. Further, this model analysis shows that myopia induction causes endoplasmic reticulum stress in a sclera and the endoplasmic reticulum stress induces myopia. Furthermore, it is revealed that an endoplasmic reticulum stress suppressant, particularly, phenylbutyrate and tauroursodeoxycholic acid act as a myopia prevention/suppression agent.
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2.发明公开公开(公告)号：US20240210736A1
公开(公告)日：2024-06-27
申请号：US18600985
申请日：2024-03-11
IPC分类号： G02C7/06 , A01K67/02 , A61K9/00 , A61K31/575
CPC分类号： G02C7/06 , A01K67/02 , A61K9/0048 , A61K31/575 , A01K2227/105 , A01K2267/03
摘要： A model that closely resembles human excessive myopia can be prepared by mounting a minus lens (2) and a protector (4) to a juvenile mouse, the minus lens having an angle and a width adjustable in response to growth of the mouse. Further, this model analysis shows that myopia induction causes endoplasmic reticulum stress in a sclera and the endoplasmic reticulum stress induces myopia. Furthermore, it is revealed that an endoplasmic reticulum stress suppressant, particularly, phenylbutyrate and tauroursodeoxycholic acid act as a myopia prevention/suppression agent.
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