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5 条记录 (耗时 0.049 秒)

    Method for measuring spinorphin
    1.
    发明申请
    Method for measuring spinorphin 审中-公开
    测定旋光子的方法

    公开(公告)号：US20060194268A1

    公开(公告)日：2006-08-31

    申请号：US11209646

    申请日：2005-08-24

    申请人： Tadahiko Hazato ,  Yukio Yamamoto ,  Yoshiro Yamamura

    发明人： Tadahiko Hazato ,  Yukio Yamamoto ,  Yoshiro Yamamura

    IPC分类号： G01N33/537 ,  G01N33/543

    CPC分类号： G01N33/564 ,  G01N2800/102

    摘要： The present invention aims at providing a method for measuring spinorphin in a sample collected from a living body accurately with high sensitivity. The present invention provides a method for measuring spinorphin in a sample collected from a living body, comprising the steps of: (A) mixing a sample collected from a living body with trichloroacetic acid to give a solution phase and subjecting said solution phase and a solvent to a reverse phase column to elute spinorphin with said solvent; (B) contacting the spinorphin eluted in the step (A) with spinorphin immobilized on a carrier and a spinorphin antibody; (C) removing the spinorphin antibody that has not been bound to the spinorphin immobilized on the carrier; (D) contacting the spinorphin antibody bound to the spinorphin immobilized on the carrier obtained in the step (C) with a labeled secondary antibody that specifically binds to said spinorphin antibody so as to bind the spinorphin antibody bound to the spinorphin immobilized on the carrier and the labeled secondary antibody; and (E) measuring the amount of label in the labeled secondary antibody bound to the spinorphin antibody.

    摘要翻译： 本发明的目的在于提供一种以高灵敏度精确地从活体收集的样品中测定旋光子的方法。 本发明提供了从活体收集的样品中测定旋光子的方法，包括以下步骤：（A）将从活体收集的样品与三氯乙酸混合，得到溶液相，并使所述溶液相和溶剂 至反相柱，用所述溶剂洗脱旋毛虫; （B）使步骤（A）中洗脱的旋毛虫与固定在载体上的旋角蛋白和spinorphin抗体接触; （C）除去未结合到固定在载体上的旋风卟啉的旋风卟啉抗体; （D）使与固定在步骤（C）中获得的载体上的旋风卟啉结合的旋丝蛋白抗体与特异性结合所述spinorphin抗体的标记的二抗接触，以结合与固定在载体上的旋风卟啉结合的鸢尾碱抗体，和 标记的二抗; 和（E）测量与spinorphin抗体结合的标记的二抗中的标记量。

    Opioid peptide-degrading enzyme inhibitor with a germanium compound
    4.
    发明授权
    Opioid peptide-degrading enzyme inhibitor with a germanium compound 失效
    阿片样肽降解酶抑制剂与锗化合物

    公开(公告)号：US4748187A

    公开(公告)日：1988-05-31

    申请号：US930561

    申请日：1986-11-14

    申请人： Norihiro Kakimoto ,  Takashi Katayama ,  Tadahiko Hazato ,  Tsutomu Ohnishi

    发明人： Norihiro Kakimoto ,  Takashi Katayama ,  Tadahiko Hazato ,  Tsutomu Ohnishi

    IPC分类号： C07F7/30 ,  A61K31/28

    CPC分类号： C07F7/30

    摘要： The present invention provides (1) a new organogermanium compound of the following general formula: ##STR1## wherein A represents a hydrogen atom, a lower alkyl group such as a methyl or ethyl group or a phenyl group, B represents a hydrogen atom or a lower alkyl group as mentioned above and Z represents a hydroxyl or amino group and (2) an opioid peptide-degrading enzyme inhibitor containing the compound (1) as a principal ingredient.

    摘要翻译： 本发明提供（1）下述通式的新的有机锗化合物：其中A表示氢原子，低级烷基如甲基或乙基或苯基，B表示氢原子或 低级烷基，Z表示羟基或氨基，（2）含有化合物（1）作为主要成分的阿片样肽降解酶抑制剂。

    Organogermanium compound
    5.
    发明授权
    Organogermanium compound 失效
    有机锗化合物

    公开(公告)号：US4681960A

    公开(公告)日：1987-07-21

    申请号：US626787

    申请日：1984-07-02

    申请人： Norihiro Kakimoto ,  Takashi Katayama ,  Tadahiko Hazato ,  Tsutomu Ohnishi

    发明人： Norihiro Kakimoto ,  Takashi Katayama ,  Tadahiko Hazato ,  Tsutomu Ohnishi

    IPC分类号： C07F7/30

    CPC分类号： C07F7/30

    摘要： The present invention provides (1) a new organogermanium compound of the following general formula: ##STR1## wherein A represents a hydrogen atom, a lower alkyl group such as a methyl or ethyl group or a phenyl group, B represents a hydrogen atom or a lower alkyl group as mentioned above and Z represents a hydroxyl or amino group and (2) an opioid peptide-degrading enzyme inhibitor containing the compound (1) as a principal ingredient.

    摘要翻译： 本发明提供（1）下述通式的新的有机锗化合物：其中A表示氢原子，低级烷基如甲基或乙基或苯基，B表示氢原子或 低级烷基，Z表示羟基或氨基，（2）含有化合物（1）作为主要成分的阿片样肽降解酶抑制剂。