专利检索 ap:("Tadakiyo Nakagawa" OR "Tamotsu Suzuki" OR "Kaoru Takenaka" OR "Shinichi Fujita" OR "Youji Yamada" OR "Yoichiro Shima" OR "Tatsuya Okuzumi" OR "Toshihiko Yoshimura" OR "Masanao Yoshida" OR "Masahiro Murata") AND inv:"Toshihiko Yoshimura" 第 1 页

1.

发明授权
Amide derivative 有权
标题翻译：酰胺衍生物

公开(公告)号：US08168827B2

公开(公告)日：2012-05-01

申请号：US12487813

申请日：2009-06-19

申请人： Tadakiyo Nakagawa , Tamotsu Suzuki , Kaoru Takenaka , Shinichi Fujita , Youji Yamada , Yoichiro Shima , Tatsuya Okuzumi , Toshihiko Yoshimura , Masanao Yoshida , Masahiro Murata

发明人： Tadakiyo Nakagawa , Tamotsu Suzuki , Kaoru Takenaka , Shinichi Fujita , Youji Yamada , Yoichiro Shima , Tatsuya Okuzumi , Toshihiko Yoshimura , Masanao Yoshida , Masahiro Murata

IPC分类号： C07C233/05 , A61K31/65

CPC分类号： C07D401/04 , C07C237/04 , C07D401/14

摘要： Amide derivatives represented by the formula (I): wherein: A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa-, —(CRbRb′)m-, and the like; m is 0 to 4; and R1 to R17 may be the same or different and each is a hydrogen atom, a halogen atom, a cyano group, a nitro group, a carboxyl group, a formyl group, a hydroxyl group, an ammonium group, an alkyl group optionally having one or more substituents, -ZR18 and the like, Z is —O—, —S(O)p-, —S(O)pO—, —NH—, —NR19-, and the like; or a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof may be applied to pharmaceutical use such as anti-inflammatory and analgesic action and the like.

摘要翻译： 由式（I）表示的酰胺衍生物：其中：A为环烷基，芳基或杂芳基; X是氮原子或CR 17; Y是-NR a - ， - （CR b R b'）m - 等; m为0〜4; R 1〜R 17可以相同或不同，各自为氢原子，卤素原子，氰基，硝基，羧基，甲酰基，羟基，铵基，任选具有一个或多个取代基，-ZR 18等，Z是-O - ， - S（O）p - ， - S（O）p O - ， - NH - ， - NR 19 - 等; 或其药学上可接受的盐，其水合物或其溶剂合物可以用于药物用途，例如抗炎和镇痛作用等。

2.

发明申请
AMIDE DERIVATIVE 有权

公开(公告)号：US20090258900A1

公开(公告)日：2009-10-15

申请号：US12487813

申请日：2009-06-19

申请人： Tadakiyo Nakagawa , Tamotsu Suzuki , Kaoru Takenaka , Shinichi Fujita , Youji Yamada , Yoichiro Shima , Tatsuya Okuzumi , Toshihiko Yoshimura , Masanao Yoshida , Masahiro Murata

发明人： Tadakiyo Nakagawa , Tamotsu Suzuki , Kaoru Takenaka , Shinichi Fujita , Youji Yamada , Yoichiro Shima , Tatsuya Okuzumi , Toshihiko Yoshimura , Masanao Yoshida , Masahiro Murata

IPC分类号： A61K31/4545 , A61K31/444 , A61P29/00 , A61P1/00 , A61P13/00 , A61P11/06 , C07D401/14 , C07D401/04

CPC分类号： C07D401/04 , C07C237/04 , C07D401/14

摘要： Amide derivatives represented by the formula (I): wherein: A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa—, —(CRbRb′)m-, and the like; m is 0 to 4; and R1 to R17 may be the same or different and each is a hydrogen atom, a halogen atom, a cyano group, a nitro group, a carboxyl group, a formyl group, a hydroxyl group, an ammonium group, an alkyl group optionally having one or more substituents, -ZR18 and the like, Z is —O—, —S(O)p-, —S(O)pO—, —NH—, —NR19-, and the like; or a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof may be applied to pharmaceutical use such as anti-inflammatory and analgesic action and the like.

摘要翻译： 由式（I）表示的酰胺衍生物：其中：A为环烷基，芳基或杂芳基; X是氮原子或CR 17; Y是-NR a - ， - （CR b R b'）m - 等; m为0〜4; R 1〜R 17可以相同或不同，各自为氢原子，卤素原子，氰基，硝基，羧基，甲酰基，羟基，铵基，任选具有一个或多个取代基，-ZR 18等，Z是-O - ， - S（O）p - ， - S（O）p O - ， - NH - ， - NR 19 - 等; 或其药学上可接受的盐，其水合物或其溶剂合物可以用于药物用途，例如抗炎和镇痛作用等。

3.

发明申请
Amide derivative 有权

公开(公告)号：US20060128755A1

公开(公告)日：2006-06-15

申请号：US11281627

申请日：2005-11-18

申请人： Tadakiyo Nakagawa , Tamotsu Suzuki , Kaoru Takenaka , Shinichi Fujita , Youji Yamada , Yoichiro Shima , Tatsuya Okuzumi , Toshihiko Yoshimura , Masanao Yoshida , Masahiro Murata

发明人： Tadakiyo Nakagawa , Tamotsu Suzuki , Kaoru Takenaka , Shinichi Fujita , Youji Yamada , Yoichiro Shima , Tatsuya Okuzumi , Toshihiko Yoshimura , Masanao Yoshida , Masahiro Murata

IPC分类号： A61K31/444 , C07D401/14

CPC分类号： C07D401/04 , C07C237/04 , C07D401/14

摘要： Amide derivatives represented by the formula (I): wherein: A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa—, —(CRbRb′)m—, and the like; m is 0 to 4; and R1 to R17 may be the same or different and each is a hydrogen atom, a halogen atom, a cyano group, a nitro group, a carboxyl group, a formyl group, a hydroxyl group, an ammonium group, an alkyl group optionally having one or more substituents, ZR18 and the like, Z is —O—, —S(O)p—, —S(O)pO—, —NH—, —NR19—, and the like; or R1 and R2 may in combination form a ring, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof may be applied to pharmaceutical use such as anti-inflammatory and analgesic action and the like.

4.

发明授权
Amide derivative 有权
标题翻译：酰胺衍生物

公开(公告)号：US07572815B2

公开(公告)日：2009-08-11

申请号：US11281627

申请日：2005-11-18

申请人： Tadakiyo Nakagawa , Tamotsu Suzuki , Kaoru Takenaka , Shinichi Fujita , Youji Yamada , Yoichiro Shima , Tatsuya Okuzumi , Toshihiko Yoshimura , Masanao Yoshida , Masahiro Murata

发明人： Tadakiyo Nakagawa , Tamotsu Suzuki , Kaoru Takenaka , Shinichi Fujita , Youji Yamada , Yoichiro Shima , Tatsuya Okuzumi , Toshihiko Yoshimura , Masanao Yoshida , Masahiro Murata

IPC分类号： C07D401/04 , A61K31/444

CPC分类号： C07D401/04 , C07C237/04 , C07D401/14

摘要： Amide derivatives represented by the formula (I): wherein: A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa—, —(CRbRb′)m-, and the like; m is 0 to 4; and R1 to R17 may be the same or different and each is a hydrogen atom, a halogen atom, a cyano group, a nitro group, a carboxyl group, a formyl group, a hydroxyl group, an ammonium group, an alkyl group optionally having one or more substituents, ZR18 and the like, Z is —O—, —S(O)p-, —S(O)pO—, —NH—, —NR19-, and the like; or R1 and R2 may in combination form a ring, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof may be applied to pharmaceutical use such as anti-inflammatory and analgesic action and the like.

摘要翻译： 由式（I）表示的酰胺衍生物：其中：A为环烷基，芳基或杂芳基; X是氮原子或CR 17; Y是-NR a - ， - （CR b R b'）m - 等; m为0〜4; R 1〜R 17可以相同或不同，各自为氢原子，卤素原子，氰基，硝基，羧基，甲酰基，羟基，铵基，任选具有一个或多个取代基，ZR 18等，Z是-O - ， - S（O）p - ， - S（O）p O - ， - NH - ， - NR 19 - 等; 或者R1和R2可以组合形成环，其药学上可接受的盐，其水合物或其溶剂合物可以用于药物用途，例如抗炎和止痛作用等。

5.

发明申请
NEW PHENYLALANINE DERIVATIVES 有权
标题翻译：新的苯乙烯胺衍生物

公开(公告)号：US20080280909A1

公开(公告)日：2008-11-13

申请号：US11767969

申请日：2007-06-25

申请人： Tatsuya Okuzumi , Kazuyuki Sagi , Toshihiko Yoshimura , Yuji Tanaka , Eiji Nakanishi , Miho Ono , Masahiro Murata

发明人： Tatsuya Okuzumi , Kazuyuki Sagi , Toshihiko Yoshimura , Yuji Tanaka , Eiji Nakanishi , Miho Ono , Masahiro Murata

IPC分类号： A61K31/47 , C07D215/227 , A61K31/502 , A61P29/00 , C07D237/32

CPC分类号： C07D209/48 , A61K31/403 , A61K31/4375 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/502 , A61K31/517 , C07D215/22 , C07D215/227 , C07D215/36 , C07D215/38 , C07D237/32 , C07D239/96 , C07D401/12 , C07D403/12 , C07D471/04

摘要： Phenylalanine derivatives of the following formula, analogues thereof and pharmaceutically acceptable salts thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning α4 integrin in which α4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection. wherein R1 is a methyl group and R2 is a methoxy group.

摘要翻译： 下式的苯丙氨酸衍生物，其类似物和其药学上可接受的盐对α4整联蛋白具有拮抗活性。它们用作涉及α4整联蛋白的各种疾病的治疗剂或预防剂，其中α4整联蛋白依赖性粘附过程参与病理学，例如炎性疾病，类风湿性关节炎，炎性肠病，系统性红斑狼疮，多发性硬化症，Siegren综合征，哮喘，牛皮癣，过敏，糖尿病，心血管疾病，动脉硬化，再狭窄，肿瘤增生，肿瘤转移和移植排斥。其中R1是甲基，R2是甲氧基。

6.

发明授权
Phenylalanine derivatives 有权
标题翻译：苯丙氨酸衍生物

公开(公告)号：US07605165B2

公开(公告)日：2009-10-20

申请号：US10921929

申请日：2004-08-20

申请人： Kazuyuki Sagi , Hiroyuki Izawa , Akira Chiba , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuji Tanaka , Miho Ono , Masahiro Murata

发明人： Kazuyuki Sagi , Hiroyuki Izawa , Akira Chiba , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuji Tanaka , Miho Ono , Masahiro Murata

IPC分类号： A61K31/517 , C07D239/88 , C07D239/96

CPC分类号： C07D265/26 , C07D239/54 , C07D239/80 , C07D239/96 , C07D253/04 , C07D285/16 , C07D285/24 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04

摘要： The present invention relates to the following phenylalanine derivatives or analogues thereof having an antagonistic activity to α4 integrin and therapeutic agents for various diseases concerning α4 integrin.

摘要翻译： 本发明涉及对α4整联蛋白具有拮抗作用的以下苯丙氨酸衍生物或其类似物，以及涉及α4整联蛋白的各种疾病的治疗剂。

7.

发明授权
Phenylpropionic acid derivatives 有权
标题翻译：苯丙酸衍生物

公开(公告)号：US07193108B2

公开(公告)日：2007-03-20

申请号：US10763237

申请日：2004-01-26

申请人： Akira Chiba , Kazuyuki Sagi , Toshihiko Yoshimura , Tatsuya Okuzumi , Hiroyuki Izawa , Masahiro Murata

发明人： Akira Chiba , Kazuyuki Sagi , Toshihiko Yoshimura , Tatsuya Okuzumi , Hiroyuki Izawa , Masahiro Murata

IPC分类号： C07C315/00 , C07C317/00 , C07C229/00 , A61K31/00

CPC分类号： A61K31/517 , A61K31/235 , C07C275/42 , C07D239/96

摘要： Specified phenylpropionic acid derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning α 4 integrin, such as inflammatory diseases in which α 4 integrin-depending adhesion process participates in the pathology, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.

摘要翻译： 指定的苯丙酸衍生物及其类似物对α4整联蛋白具有拮抗作用。它们被用作关于α4整联蛋白的各种疾病的治疗剂或预防剂，例如其中α4整联蛋白依赖性粘附过程参与病理学，类风湿性关节炎，炎性肠病，系统性红斑狼疮，多发性硬化症，Sjögren's 综合征，哮喘，牛皮癣，过敏，糖尿病，心血管疾病，动脉硬化，再狭窄，肿瘤增殖，肿瘤转移和移植排斥。