2-Diphenylmethyleneamino-3-indolylpropionitrile and alkyl esters of
2-diphenylmethylene-amino-3-indolylpropionic acid
    2.
    发明授权
    2-Diphenylmethyleneamino-3-indolylpropionitrile and alkyl esters of 2-diphenylmethylene-amino-3-indolylpropionic acid 失效
    2-二苯基亚甲基氨基-3-吲哚基丙腈和2-二苯基亚甲基 - 氨基-3-吲哚基丙酸的烷基酯

    公开(公告)号:US4399289A

    公开(公告)日:1983-08-16

    申请号:US247938

    申请日:1981-03-26

    IPC分类号: C07D209/20 C07D209/18

    CPC分类号: C07D209/20 Y02P20/582

    摘要: Novel indole derivatives of the general formula I can be obtained by reacting, directly or indirectly, N,N-dimethyl-3-indolemethylamine with a Schiff base of the general formula II, ##STR1## in which R.sup.1 is cyano or methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl or butoxycarbonyl, and .phi. is phenyl. The successive hydrolysis of the indole derivatives of the general formula I in the presence of an acid and of a base gives tryptophane.

    摘要翻译: 通式I的新型吲哚衍生物可以通过直接或间接地使N,N-二甲基-3-吲哚甲胺与通式II的希夫碱反应获得,其中R 1是氰基 或甲氧基羰基,乙氧基羰基,丙氧基羰基或丁氧基羰基,而phi为苯基。 在酸和碱的存在下,通式I的吲哚衍生物的连续水解得到色氨酸。