公开(公告)号：US20130043503A1

公开(公告)日：2013-02-21

申请号：US13330315

申请日：2011-12-19

申请人： Taeil JUNG ,  YoungChae Kim ,  SunMan Kim ,  Yeji Han ,  Chunghoon Park ,  Byeong-Kyun Choi ,  Se-Eun Kang

发明人： Taeil JUNG ,  YoungChae Kim ,  SunMan Kim ,  Yeji Han ,  Chunghoon Park ,  Byeong-Kyun Choi ,  Se-Eun Kang

IPC分类号： H01L33/42 ,  H01L33/62

CPC分类号： H01L33/42 ,  H01L33/20

摘要： A semiconductor light emitting device, which includes a light transmissive electrode layer formed using a conductive thin film and an insulating thin film to substitute for a transparent electrode layer, comprises a substrate; a first semiconductor layer formed on the substrate; an active layer formed on the first semiconductor layer; a second semiconductor layer formed on the active layer; a light transmissive electrode layer formed on the second semiconductor layer, the light transmissive electrode layer having a structure in which at least one conductive thin film and at least one insulating thin film are deposited; and a first electrode formed on the light transmissive electrode layer, wherein the light transmissve electrode layer includes at least one contact portion for contacting the at least one conductive thin film with the first electrode.

摘要翻译： 包括使用导电薄膜形成的透光电极层和用于代替透明电极层的绝缘薄膜的半导体发光器件包括衬底; 形成在所述基板上的第一半导体层; 形成在所述第一半导体层上的有源层; 形成在所述有源层上的第二半导体层; 形成在所述第二半导体层上的透光电极层，所述透光电极层具有其中沉积至少一个导电薄膜和至少一个绝缘薄膜的结构; 以及形成在所述透光电极层上的第一电极，其中所述透光电极层包括用于使所述至少一个导电薄膜与所述第一电极接触的至少一个接触部分。

公开(公告)号：US08912028B2

公开(公告)日：2014-12-16

申请号：US13330315

申请日：2011-12-19

申请人： Taeil Jung ,  YoungChae Kim ,  SunMan Kim ,  Yeji Han ,  Chunghoon Park ,  Byeong-Kyun Choi ,  Se-Eun Kang

发明人： Taeil Jung ,  YoungChae Kim ,  SunMan Kim ,  Yeji Han ,  Chunghoon Park ,  Byeong-Kyun Choi ,  Se-Eun Kang

IPC分类号： H01L33/42 ,  H01L33/20

CPC分类号： H01L33/42 ,  H01L33/20

摘要： A semiconductor light emitting device, which includes a light transmissive electrode layer formed using a conductive thin film and an insulating thin film to substitute for a transparent electrode layer, comprises a substrate; a first semiconductor layer formed on the substrate; an active layer formed on the first semiconductor layer; a second semiconductor layer formed on the active layer; a light transmissive electrode layer formed on the second semiconductor layer, the light transmissive electrode layer having a structure in which at least one conductive thin film and at least one insulating thin film are deposited; and a first electrode formed on the light transmissive electrode layer, wherein the light transmissve electrode layer includes at least one contact portion for contacting the at least one conductive thin film with the first electrode.

摘要翻译： 包括使用导电薄膜形成的透光电极层和用于代替透明电极层的绝缘薄膜的半导体发光器件包括衬底; 形成在所述基板上的第一半导体层; 形成在所述第一半导体层上的有源层; 形成在所述有源层上的第二半导体层; 形成在所述第二半导体层上的透光电极层，所述透光电极层具有其中沉积至少一个导电薄膜和至少一个绝缘薄膜的结构; 以及形成在所述透光电极层上的第一电极，其中所述透光电极层包括用于使所述至少一个导电薄膜与所述第一电极接触的至少一个接触部分。

公开(公告)号：US20110021442A1

公开(公告)日：2011-01-27

申请号：US12741138

申请日：2008-11-06

申请人： Daewoong Jo ,  Eun Kyung Hong ,  Jung-Hee Lim ,  Se-Eun Kang ,  Lihua Che

发明人： Daewoong Jo ,  Eun Kyung Hong ,  Jung-Hee Lim ,  Se-Eun Kang ,  Lihua Che

IPC分类号： A61K38/00 ,  C07K14/00 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12P21/06 ,  A61P35/00 ,  A61P35/04

CPC分类号： C07K14/4702 ,  C07K2319/09 ,  C07K2319/10 ,  C07K2319/21

摘要： The present invention discloses cell permeable RUNX3 recombinant proteins where a Macromolecule Transduction Domain (MTD) is fused to a tumor and metastasis suppressor RUNX3. Also disclosed are polynucleotides encoding the cell permeable RUNX3 recombinant proteins, an expression vector containing the cell permeable RUNX3 recombinant protein, and a pharmaceutical composition for preventing metastasis which contains the cell permeable RUNX3 recombinant protein as an effective ingredient. The cell permeable RUNX3 recombinant proteins of the present invention can induce the reactivation of TGF-β signal transduction pathway which causes cell cycle arrest by efficiently introducing a tumor and metastasis suppressor RUNX3 into a cell. Therefore, the cell permeable RUNX3 recombinant proteins of the present invention can be effectively used as an anticancer agent capable of preventing cancer growth and metastasis by suppressing the proliferation, differentiation, and migration of cancer cells.

摘要翻译： 本发明公开了细胞渗透性RUNX3重组蛋白，其中大分子转导结构域（MTD）与肿瘤融合，转移抑制因子RUNX3。 还公开了编码细胞可渗透性RUNX3重组蛋白的多核苷酸，含有细胞可渗透性RUNX3重组蛋白的表达载体和用于预防转移的药物组合物，其含有可透过细胞的RUNX3重组蛋白作为有效成分。 本发明的细胞渗透性RUNX3重组蛋白可以诱导TGF- 信号转导途径，通过有效地将肿瘤和转移抑制剂RUNX3引入细胞而引起细胞周期阻滞。 因此，通过抑制癌细胞的增殖，分化和迁移，本发明的细胞可渗透的RUNX3重组蛋白可以有效地用作能够预防癌症生长和转移的抗癌剂。

公开(公告)号：US08445443B2

公开(公告)日：2013-05-21

申请号：US12676491

申请日：2008-09-04

申请人： Daewoong Jo ,  Seolhwa Kim ,  Jung-Hee Lim ,  Kisuk Park ,  Se-Eun Kang

发明人： Daewoong Jo ,  Seolhwa Kim ,  Jung-Hee Lim ,  Kisuk Park ,  Se-Eun Kang

IPC分类号： C12N15/62

CPC分类号： C07K14/4703 ,  C07K14/50 ,  C07K2319/033

摘要： The present invention discloses cell permeable p18 recombinant proteins where a macromolecule transduction domain (MTD) is fused to a tumor suppressor p18. Also disclosed are polynucleotides encoding the cell permeable p18 recombinant proteins, an expression vector containing the cell permeable p18 recombinant protein, and a pharmaceutical composition for treating p18 deficiency or failure which contains the cell permeable p18 recombinant protein as an effective ingredient. The cell permeable p18 recombinant proteins of the present invention are capable of efficiently introducing a haploinsufficient tumor suppressor p18 into a cell, and thus, can activate cell signaling mechanisms involved in the activation of ATM and p53 that induce cell cycle arrest and apoptosis in response to DNA damage or oncogenic signals. Therefore, the cell permeable p18 recombinant proteins of the present invention can be effectively used as an anticancer agent.

摘要翻译： 本发明公开了一种细胞渗透性p18重组蛋白，其中大分子转导结构域（MTD）与肿瘤抑制基因p18融合。 还公开了编码细胞可渗透性p18重组蛋白质的多核苷酸，含有细胞可渗透性p18重组蛋白质的表达载体和含有细胞可渗透性p18重组蛋白质作为有效成分的p18缺陷或失败的药物组合物。 本发明的细胞可渗透性p18重组蛋白能够有效地将不充分的单倍体肿瘤抑制基因p18引入细胞，从而可以激活参与ATM和p53激活的细胞信号传导机制，诱导细胞周期停滞和凋亡，以响应于 DNA损伤或致癌信号。 因此，本发明的细胞可渗透性p18重组蛋白质可以有效地用作抗癌剂。

公开(公告)号：US20100305041A1

公开(公告)日：2010-12-02

申请号：US12676491

申请日：2008-09-04

申请人： Daewoong Jo ,  Seolhwa Kim ,  Jung-Hee Lim ,  Kisuk Park ,  Se-Eun Kang

发明人： Daewoong Jo ,  Seolhwa Kim ,  Jung-Hee Lim ,  Kisuk Park ,  Se-Eun Kang

IPC分类号： A61K38/17 ,  C07K14/435 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12P21/02 ,  A61P35/00

CPC分类号： C07K14/4703 ,  C07K14/50 ,  C07K2319/033

摘要： The present invention discloses cell permeable p18 recombinant proteins where a macromolecule transduction domain (MTD) is fused to a tumor suppressor p18. Also disclosed are polynucleotides encoding the cell permeable p18 recombinant proteins, an expression vector containing the cell permeable p18 recombinant protein, and a pharmaceutical composition for treating p18 deficiency or failure which contains the cell permeable p18 recombinant protein as an effective ingredient. The cell permeable p18 recombinant proteins of the present invention are capable of efficiently introducing a haploinsufficient tumor suppressor p18 into a cell, and thus, can activate cell signaling mechanisms involved in the activation of ATM and p53 that induce cell cycle arrest and apoptosis in response to DNA damage or oncogenic signals. Therefore, the cell permeable p18 recombinant proteins of the present invention can be effectively used as an anticancer agent.

摘要翻译： 本发明公开了一种细胞渗透性p18重组蛋白，其中大分子转导结构域（MTD）与肿瘤抑制基因p18融合。 还公开了编码细胞可渗透性p18重组蛋白质的多核苷酸，含有细胞可渗透性p18重组蛋白质的表达载体和含有细胞可渗透性p18重组蛋白质作为有效成分的p18缺陷或失败的药物组合物。 本发明的细胞可渗透性p18重组蛋白能够有效地将不充分的单倍体肿瘤抑制基因p18引入细胞，从而可以激活参与ATM和p53激活的细胞信号传导机制，诱导细胞周期停滞和凋亡，以响应于 DNA损伤或致癌信号。 因此，本发明的细胞可渗透性p18重组蛋白质可以有效地用作抗癌剂。