公开(公告)号：US09017719B2

公开(公告)日：2015-04-28

申请号：US13541413

申请日：2012-07-03

申请人： Taeun Park ,  Jin-Ho Choy ,  Jae-Min Oh ,  Ji-Sun Jung

发明人： Taeun Park ,  Jin-Ho Choy ,  Jae-Min Oh ,  Ji-Sun Jung

IPC分类号： A61K9/127 ,  A61K9/00 ,  A61K9/14 ,  A61K47/02

CPC分类号： A61K9/0019 ,  A61K9/143 ,  A61K47/02

摘要： Provided is an injectable drug carrier including a non-toxic Layered Double Hydroxide (LDH) and pharmaceutically acceptable excipients. Provided is also a method of preparing the injectable drug carrier, the method including: synthesizing LDH with various compositions and controlling the size and shape of the LDH at a level that the LDH has no adverse effect in vivo. A solution obtained by dispersing the LDH in a solvent is injected in vivo. According to the method, nano-size LDH that does not affect a blood vessel in vivo can be synthesized. The LDH thus synthesized has no adverse effect in vivo even at a concentration of 400 mg/kg, and thus can contribute to establishment of a drug delivery system capable of improving the delivery efficiency of a specific drug.

摘要翻译： 提供了包含无毒层状双氢氧化物（LDH）和药学上可接受的赋形剂的可注射药物载体。 还提供了一种制备可注射药物载体的方法，该方法包括：以各种组成合成LDH，并以LDH在体内没有不利影响的水平控制LDH的大小和形状。 将LDH分散在溶剂中得到的溶液体内注射。 根据该方法，可以合成不影响体内血管的纳米级LDH。 如此合成的LDH即使在400mg / kg的浓度下也不会在体内产生不利影响，因此有助于建立能够提高特定药物的输送效率的药物输送系统。

公开(公告)号：US20100047307A1

公开(公告)日：2010-02-25

申请号：US11915922

申请日：2005-06-03

申请人： Taeun Park ,  Jin-ho Choy ,  Jae-Min Oh ,  Ji-Sun Jung

发明人： Taeun Park ,  Jin-ho Choy ,  Jae-Min Oh ,  Ji-Sun Jung

IPC分类号： A61K9/14 ,  A61K31/519 ,  A61P35/00 ,  A61P37/02

CPC分类号： A61K9/0019 ,  A61K9/143 ,  A61K47/02

摘要： Provided is an injectable drug carrier including a non-toxic Layered Double Hydroxide (LDH) and pharmaceutically acceptable excipients. Provided is also a method of preparing the injectable drug carrier, the method including: synthesizing LDH with various compositions and controlling the size and shape of the LDH at a level that the LDH has no adverse effect in vivo. A solution obtained by dispersing the LDH in a solvent is injected in vivo. According to the method, nano-size LDH that does not affect a blood vessel in vivo can be synthesized. The LDH thus synthesized has no adverse effect in vivo even at a concentration of 400 mg/kg, and thus can contribute to establishment of a drug delivery system capable of improving the delivery efficiency of a specific drug.

摘要翻译： 提供了包含无毒层状双氢氧化物（LDH）和药学上可接受的赋形剂的可注射药物载体。 还提供了一种制备可注射药物载体的方法，该方法包括：以各种组成合成LDH，并以LDH在体内没有不利影响的水平控制LDH的大小和形状。 将LDH分散在溶剂中得到的溶液体内注射。 根据该方法，可以合成不影响体内血管的纳米级LDH。 如此合成的LDH即使在400mg / kg的浓度下也不会在体内产生不利影响，因此有助于建立能够提高特定药物的输送效率的药物输送系统。