RECEIVING SHEET FOR DYE-SUBLIMATION HEAT TRANSFER RECORDING AND METHOD FOR MANUFACTURING THE SAME
    1.
    发明申请
    RECEIVING SHEET FOR DYE-SUBLIMATION HEAT TRANSFER RECORDING AND METHOD FOR MANUFACTURING THE SAME 审中-公开
    用于染色热转印记录的接收片及其制造方法

    公开(公告)号:US20110052842A1

    公开(公告)日:2011-03-03

    申请号:US12936206

    申请日:2010-04-23

    IPC分类号: B05D5/04 B41M5/40

    摘要: The present invention relates to a receiving sheet for dye-sublimation thermal transfer recording and a method for manufacturing the same, and more particularly to a receiving sheet for dye-sublimation thermal transfer recording, which includes a base layer, a back coating layer formed on one surface of the base layer, and an ink-receiving layer formed on the surface opposite the surface of the base layer on which the back coating layer is formed, the ink-receiving layer containing porous metal oxide nanoparticles, and a method for manufacturing the same. The inventive receiving sheet for dye-sublimation thermal transfer recording includes the ink-receiving layer containing porous metal oxide nanoparticles. Thus, the resolution of images on the receiving sheet can be maintained, while the resistance to thermal deformation and durability of the receiving sheet can be greatly improved, thus offering many advantages in terms of image quality or cost.

    摘要翻译: 本发明涉及一种用于染色升华热转印记录的接收片及其制造方法,更具体地涉及一种用于染色升华热转印记录的接收片,其包括基底层,形成在 基底层的一个表面和形成在与形成背面涂层的基底层的表面相对的表面上的墨水接收层,含有多孔金属氧化物纳米颗粒的墨水接受层,以及制造 相同。 本发明的染色升华热转印记录用接收片包括含有多孔金属氧化物纳米粒子的油墨接收层。 因此,可以保持接收片材上的图像分辨率,同时可以大大提高接收片材的耐热变形性和耐久性,从而在图像质量或成本方面提供许多优点。

    INJECTABLE DRUG CARRIER COMPRISING LAYERED DOUBLE HYDROXIDE
    7.
    发明申请
    INJECTABLE DRUG CARRIER COMPRISING LAYERED DOUBLE HYDROXIDE 有权
    包含层状双氢氧化物的注射式药物载体

    公开(公告)号:US20120276170A1

    公开(公告)日:2012-11-01

    申请号:US13541413

    申请日:2012-07-03

    摘要: Provided is an injectable drug carrier including a non-toxic Layered Double Hydroxide (LDH) and pharmaceutically acceptable excipients. Provided is also a method of preparing the injectable drug carrier, the method including: synthesizing LDH with various compositions and controlling the size and shape of the LDH at a level that the LDH has no adverse effect in vivo. A solution obtained by dispersing the LDH in a solvent is injected in vivo. According to the method, nano-size LDH that does not affect a blood vessel in vivo can be synthesized. The LDH thus synthesized has no adverse effect in vivo even at a concentration of 400 mg/kg, and thus can contribute to establishment of a drug delivery system capable of improving the delivery efficiency of a specific drug.

    摘要翻译: 提供了包含无毒层状双氢氧化物(LDH)和药学上可接受的赋形剂的可注射药物载体。 还提供了一种制备可注射药物载体的方法,该方法包括:以各种组成合成LDH,并以LDH在体内没有不利影响的水平控制LDH的大小和形状。 将LDH分散在溶剂中得到的溶液体内注射。 根据该方法,可以合成不影响体内血管的纳米级LDH。 如此合成的LDH即使在400mg / kg的浓度下也不会在体内产生不利影响,因此有助于建立能够提高特定药物的输送效率的药物输送系统。

    NANO-HYBRID OF TARGETABLE SIRNA-LAYERED INORGANIC HYDROXIDE, MANUFACTURING METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR TREATING TUMOR COMPRISING THE NANO-HYBRID
    8.
    发明申请
    NANO-HYBRID OF TARGETABLE SIRNA-LAYERED INORGANIC HYDROXIDE, MANUFACTURING METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR TREATING TUMOR COMPRISING THE NANO-HYBRID 审中-公开
    纳米混合型SIRNA层状无机氢氧化物,其制造方法和药物组合物,用于治疗包含纳米混合物的肿瘤

    公开(公告)号:US20120220647A1

    公开(公告)日:2012-08-30

    申请号:US13496108

    申请日:2009-09-14

    IPC分类号: A61K31/7088 A61P35/00

    CPC分类号: A61K9/0019

    摘要: A nanohybrid of the potent gene therapeutic agent siRNA (small interfering RNA) and a target-specific layered inorganic hydroxide, a preparation method thereof, and a pharmaceutical composition for tumor treatment containing the target-specific, siRNA/layered inorganic hydroxide nanohybrid. The nanohybrid increases the in vivo stability of the siRNA, and a target-specific multifunctional ligand, which is bonded to the layered inorganic hydroxide and can bind specifically to a tumor, increases the efficiency of tumor-specific transfer of the siRNA such that the siRNA shows tumor therapeutic activity even at a relatively low dose. Thus, the nanohybrid will be widely useful for target-specific antitumor therapies.

    摘要翻译: 强力基因治疗剂siRNA(小干扰RNA)和靶特异性层状无机氢氧化物的纳米杂交体及其制备方法和含有目标特异性siRNA /层状无机氢氧化物纳米混合物的肿瘤治疗用药物组合物。 纳米混合物增加了siRNA的体内稳定性,并且与层状无机氢氧化物结合并可以特异性结合到肿瘤的靶特异性多功能配体增加了siRNA的肿瘤特异性转移的效率,使得siRNA 即使在相对低的剂量下也显示肿瘤治疗活性。 因此,纳米混合物将广泛用于靶特异性抗肿瘤治疗。

    Bio-inorganic compound capable of stable, solid-state storage of genes and preparation thereof
    10.
    发明授权
    Bio-inorganic compound capable of stable, solid-state storage of genes and preparation thereof 有权
    能够稳定,固态储存基因的生物无机化合物及其制备方法

    公开(公告)号:US06329515B1

    公开(公告)日:2001-12-11

    申请号:US09393981

    申请日:1999-09-10

    IPC分类号: C07H2100

    CPC分类号: C12N15/1003

    摘要: Disclosed is a bio-inorganic hybrid composite for retaining and carrying bio-materials with stability and reversible dissociativity, represented by the following chemical Formula I and a method for preparing the same. The bio-inorganic hybrid composite is prepared by (a) coprecipitating with an alkaline material an aqueous solution comprising a bivalent metal (M(II)) and a trivalent metal (N(III)) at a molar ratio satisfying the condition of ⅕≦b/(a+b)≦½ wherein a and b represent a mole number of M and N, respectively, to form a stable layered double hydroxide in which anions are intercalated and (b) subjecting the intercalated anions to ion exchange reaction with a bio-material to compensate for layer charges of the layered double hydroxide. This composite is harmless to the body and artificially controls the appropriate expression of the bio-material retained therein. [M2+1−xN3+x(Oh)2][ABIOn−]x/n.yH2O  [I] wherein, M is a bivalent metal cation; N is a trivalent metal cation; ABIO is an anionic bio-material with n charges; x is a rational number between 0 to 1; and y is a positive number.

    摘要翻译: 公开了一种用于保持和携带具有稳定性和可逆解离性的生物材料的生物 - 无机杂化复合材料,其由以下化学式I表示,及其制备方法。 生物 - 无机杂化复合物通过以下步骤制备:(a)以满足条件⅕的摩尔比与碱性物质共沉淀包含二价金属(M(II))和三价金属(N(III))的水溶液, = b /(a + b)<=½其中a和b分别表示M和N的摩尔数,以形成其中插入阴离子的稳定的层状双氢氧化物,(b)使插入的阴离子进行离子交换反应 用生物材料来补偿层状双氢氧化物的层电荷。 这种复合物对人体无害,人为地控制其中保留的生物材料的合适表达。其中M是二价金属阳离子; N是三价金属阳离子; ABIO是具有n个电荷的阴离子生物材料; x是 0到1之间的有理数; 安迪是一个正数。