-
公开(公告)号:US20090270365A1
公开(公告)日:2009-10-29
申请号:US12496993
申请日:2009-07-02
申请人: Takahiro KURAMOCHI , Norio ASAI , Kazuhiro IKEGAI , Seijiro AKAMATSU , Hironori HARADA , Noriko ISHIKAWA , Shohei SHIRAKAMI , Satoshi MIYAMOTO , Toshihiro WATANABE , Tetsuo KISO
发明人: Takahiro KURAMOCHI , Norio ASAI , Kazuhiro IKEGAI , Seijiro AKAMATSU , Hironori HARADA , Noriko ISHIKAWA , Shohei SHIRAKAMI , Satoshi MIYAMOTO , Toshihiro WATANABE , Tetsuo KISO
IPC分类号: A61K31/55 , C07D413/02 , C07D223/04 , C07D401/04 , A61K31/5377 , A61K31/497 , A61P29/00
CPC分类号: C07C237/40 , A61K31/167 , A61K31/428 , A61K31/4453 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D209/08 , C07D209/34 , C07D213/75 , C07D215/38 , C07D217/04 , C07D223/16 , C07D231/56 , C07D235/06 , C07D241/42 , C07D249/18 , C07D263/58 , C07D265/36 , C07D277/64 , C07D277/82 , C07D279/16 , C07D295/155 , C07D307/79 , C07D317/66 , C07D333/54 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要: There is provided a compound having a capsaicin receptor VR1 inhibitory activity and useful as a therapeutic agent for various pains including inflammatory pain and neurogenic pain, migraine, cluster headache, bladder diseases including overactive bladder, and the like.A benzamide derivative or a salt thereof wherein a benzene ring is attached to a D ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring) through an amide bond, the benzene ring is directly bonded to an E ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring), and the benzene ring is further bonded to A (an amino moiety, a monocyclic or bicyclic heterocycle) through L (a lower alkylene).
摘要翻译: 提供了具有辣椒素受体VR1抑制活性的化合物,并且可用作各种疼痛的治疗剂,包括炎性疼痛和神经源性疼痛,偏头痛,丛集性头痛,包括膀胱活动过度的膀胱疾病等。 一种苯甲酰胺衍生物或其盐,其中苯环通过酰胺键连接到D环(单环或双环烃环或单环或双环杂芳族环),苯环直接键合到E环(单环 或双环烃环或单环或双环杂芳族环),并且苯环通过L(低级亚烷基)进一步与A(氨基部分,单环或双环杂环)键合。