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17 条记录 (耗时 0.026 秒)

    Macrolide compounds, their preparation and their use
    1.
    发明授权
    Macrolide compounds, their preparation and their use 失效
    大环内酯类化合物，其制备及其用途

    公开(公告)号：US5212322A

    公开(公告)日：1993-05-18

    申请号：US644100

    申请日：1991-01-22

    申请人： Takao Okazaki ,  Shuji Takahashi ,  Seigo Iwado ,  Keiji Tanaka ,  Toshiaki Yanai ,  Hisaki Kajino

    发明人： Takao Okazaki ,  Shuji Takahashi ,  Seigo Iwado ,  Keiji Tanaka ,  Toshiaki Yanai ,  Hisaki Kajino

    IPC分类号： A01N49/00 ,  C07H19/01 ,  C12P17/18

    CPC分类号： C07H19/01 ,  A01N49/00 ,  C12P17/181 ,  Y02P20/55 ,  Y10S424/08

    摘要： Compounds with acaricidal, insecticidal and anthelmintic activities have the formula: ##STR1## wherein: --X--Y-- is selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CHOH--, --CH.dbd.CH--, and --CH.sub.2 --C(.dbd.O)--;R.sup.1 is selected from the group consisting of a methyl group, an ethyl group, an isopropyl group, a sec-butyl group and groups of formula --C(CH.sub.3).dbd.CHR.sup.5 in which R.sup.5 is selected from the group consisting of a methyl group, an ethyl group and an isopropyl group;R.sup.2 represents a group of formula --(CH.sub.2).sub.n --C(R.sup.6).dbd.C(R.sup.7)(R.sup.8) in which n is 0, 1 or 2, R.sup.6 and R.sup.7 each is selected from the group consisting of a hydrogen atom and a methyl group and R.sup.8 is selected from the group consisting of a hydrogen atom, a C.sub.1-4 alkyl group, a phenyl group and a phenyl group substituted with at least one substituent selected from the group consisting of halogen, methyl and nitro substituents;R.sup.3 is selected from the group consisting of a hydrogen atom, a methyl group, a hydroxy-protecting group, an ester-forming carboxylic acid residue, and an ester-forming carbonic acid residue; andR.sup.4 is selected from the group consisting of a hydrogen atom and an .alpha.-L-oleandrosyl-.alpha.-L-oleandrosyloxy group, with the proviso that R.sup.4 represents a hydrogen atom when the group R.sup.1 is selected from the group consisting of a methyl group, an ethyl group, and groups of formula --C(CH.sub.3).dbd.CHR.sup.5 in which R.sup.5 is selected from the group consisting of a methyl group, an ethyl group and an isopropyl group.

    摘要翻译： 具有杀螨，杀虫和驱虫活性的化合物具有下式：其中：-XY-选自-CH 2 -CH 2 - ， - CH 2 -CHOH - ， - CH = CH-和 - CH2-C（= O） - ; R 1选自甲基，乙基，异丙基，仲丁基和式-C（CH 3）= CHR 5的基团，其中R 5选自甲基， 乙基和异丙基; R 2表示式 - （CH 2）n C（R 6）= C（R 7）（R 8）的基团，其中n为0,1或2，R 6和R 7各自为氢原子和甲基 并且R 8选自氢原子，C 1-4烷基，苯基和被至少一个选自卤素，甲基和硝基取代基的取代基取代的苯基; R3选自氢原子，甲基，羟基保护基，成酯羧酸残基和形成酯的碳酸残基; 并且R 4选自氢原子和α-L-甘氨酰基-α-L-胆碱基氧基，条件是当R 1选自甲基时，R 4表示氢原子 ，乙基和式-C（CH 3）= CHR 5基团，其中R 5选自甲基，乙基和异丙基。

    Macrolide compounds, their preparation and their use
    2.
    发明授权
    Macrolide compounds, their preparation and their use 失效
    大环内酯类化合物，其制备及其用途

    公开(公告)号：US5008191A

    公开(公告)日：1991-04-16

    申请号：US131413

    申请日：1987-12-10

    申请人： Takao Okazaki ,  Shuji Takahashi ,  Seigo Iwado ,  Keiji Tanaka ,  Toshiaki Yanai ,  Hisaki Kajino

    发明人： Takao Okazaki ,  Shuji Takahashi ,  Seigo Iwado ,  Keiji Tanaka ,  Toshiaki Yanai ,  Hisaki Kajino

    IPC分类号： C07D493/22 ,  A01N43/90 ,  A01N49/00 ,  A01P7/02 ,  A01P7/04 ,  C07D307/00 ,  C07D309/00 ,  C07H19/01 ,  C12P17/18 ,  C12P19/54

    CPC分类号： C07H19/01 ,  A01N49/00 ,  C12P17/181 ,  Y02P20/55 ,  Y10S435/898

    摘要： Compounds with acaricidal, insecticidal and anthelmintic activities have the formula: ##STR1## wherein: --X--Y-- is selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CHOH--, --CH.dbd.CH--, and --CH.sub.2 --C(.dbd.O)--;R.sup.1 is selected from the group consisting of a methyl group, an ethyl group, an isopropyl group, a sec-butyl group and groups of formula --C(CH.sub.3).dbd.CHR.sup.5 in which R.sup.5 is selected from the group consisting of a methyl group, an ethyl group and an isopropyl group;R.sup.2 represents a group of formula --(CH.sub.2).sub.n --C(R.sup.6).dbd.C(R.sup.7)(R.sup.8) in which n is 0, 1 or 2, R.sup.6 and R.sup.7 each is selected from the group consisting of a hydrogen atom and a methyl group and R.sup.8 is selected from the group consisting of a hydrogen atom, a C.sub.1-4 alkyl group, a phenyl group and a phenyl group substituted with at least one substituent selected from the group consisting of halogen, methyl and nitro substitutents;R.sup.3 is selected from the group consisting of a hydrogen atom, a methyl group, a hydroxy-protecting group, an ester-forming carboxylic acid residue, and an ester-forming carbonic acid residue; andR.sup.4 is selected from the group consisting of a hydrogen atom and an .alpha.-L-oleandrosyl-.alpha.-L-oleandrosyloxy group, with the proviso that R.sup.4 represents a hydrogen atom when the group R.sup.1 is selected from the group consisting of a methyl group, an ethyl group, and groups of formula --C(CH.sub.3).dbd.CHR.sup.5 in which R.sup.5 is selected from the group consisting of a methyl group, an ethyl group and an isopropyl group.