Antibiotic bluensin and method of production
    4.
    发明授权
    Antibiotic bluensin and method of production 失效
    抗生素蓝蛋白和生产方法

    公开(公告)号:US3880827A

    公开(公告)日:1975-04-29

    申请号:US12973961

    申请日:1961-08-07

    申请人: UPJOHN CO

    摘要: This invention relates to a novel composition of matter and to a process for the production thereof. More particularly, this invention relates to a new compound, bluensin, and to a process for the production thereof and its use as antibacterial agent.

    摘要翻译: 本发明涉及一种新型的物质组合物及其生产方法。 更具体地说,本发明涉及新化合物,蓝青霉素及其生产方法及其作为抗菌剂的用途。

    Macrolide compounds, their preparation and their use
    5.
    发明授权
    Macrolide compounds, their preparation and their use 失效
    大环内酯类化合物,其制备及其用途

    公开(公告)号:US5008191A

    公开(公告)日:1991-04-16

    申请号:US131413

    申请日:1987-12-10

    摘要: Compounds with acaricidal, insecticidal and anthelmintic activities have the formula: ##STR1## wherein: --X--Y-- is selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CHOH--, --CH.dbd.CH--, and --CH.sub.2 --C(.dbd.O)--;R.sup.1 is selected from the group consisting of a methyl group, an ethyl group, an isopropyl group, a sec-butyl group and groups of formula --C(CH.sub.3).dbd.CHR.sup.5 in which R.sup.5 is selected from the group consisting of a methyl group, an ethyl group and an isopropyl group;R.sup.2 represents a group of formula --(CH.sub.2).sub.n --C(R.sup.6).dbd.C(R.sup.7)(R.sup.8) in which n is 0, 1 or 2, R.sup.6 and R.sup.7 each is selected from the group consisting of a hydrogen atom and a methyl group and R.sup.8 is selected from the group consisting of a hydrogen atom, a C.sub.1-4 alkyl group, a phenyl group and a phenyl group substituted with at least one substituent selected from the group consisting of halogen, methyl and nitro substitutents;R.sup.3 is selected from the group consisting of a hydrogen atom, a methyl group, a hydroxy-protecting group, an ester-forming carboxylic acid residue, and an ester-forming carbonic acid residue; andR.sup.4 is selected from the group consisting of a hydrogen atom and an .alpha.-L-oleandrosyl-.alpha.-L-oleandrosyloxy group, with the proviso that R.sup.4 represents a hydrogen atom when the group R.sup.1 is selected from the group consisting of a methyl group, an ethyl group, and groups of formula --C(CH.sub.3).dbd.CHR.sup.5 in which R.sup.5 is selected from the group consisting of a methyl group, an ethyl group and an isopropyl group.